Hemophagocytic lymphohistiocytosis with isolated central nervous system reactivation and optic nerve involvement

Journal of Child Neurology

Volumn 27, Issue 10, 2012, Pages 1336-1339

  Chong, Kok Wee ^a   Lee, Jan Hau ^a,b   Choong, Chew Thye ^a   Med, M ^a   Chan, Derrick Wei Shih ^a   Fortier, Marielle V ^a   Chan, Mei Yoke ^a  

^a KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

central nervous system; hemophagocytic lymphohistiocytosis; optic nerve

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; ETIRACETAM; ETOPOSIDE; PERFORIN; PHENOBARBITAL;

ANEMIA; ARTICLE; BRAIN ATROPHY; CASE REPORT; CAUSE OF DEATH; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID EXAMINATION; CYTOMEGALOVIRUS INFECTION; FACIAL NERVE PARALYSIS; FEMALE; FEVER; GENE MUTATION; GENETIC ANALYSIS; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HUMAN; INFANT; LIMB MOVEMENT; LUNG ASPERGILLOSIS; MAINTENANCE CHEMOTHERAPY; MOTOR NEURON DISEASE; MYOCLONUS; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE DISEASE; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PLEOCYTOSIS; PNEUMONIA; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; SEIZURE; THROMBOCYTOPENIA;

CENTRAL NERVOUS SYSTEM; FEMALE; HUMANS; INFANT; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MAGNETIC RESONANCE IMAGING; MUTATION; OPTIC NERVE; PORE FORMING CYTOTOXIC PROTEINS; STEM CELL TRANSPLANTATION;

EID: 84866850944     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073811435237     Document Type: Article

References (15)

1. Janka GE. Familial and acquired hemophagocytic lymphohistiocytosis. Eur J Pediatr. 2007 ; 166: 95-109
2. Haddad E, Sulis ML, Jabado N, et al. Frequency and severity of central nervous system lesions in hemophagocytic lymphohistiocytosis. Blood. 1997 ; 89: 794-800
3. Henter JI, Nennesmo I. Neuropathological findings and neurological symptoms in 23 children with hemophagocytic lymphohistiocytosis. J Pediatr. 1997 ; 130: 358-365
4. Horne A, Trottestam H, Arico M, et al. Frequency and spectrum of CNS involvement in 193 children with hemophagocytic lymphohistiocytosis. Br J Haematol. 2008 ; 140: 327-335
5. Shuang Y, Zhang L, Jia C, et al. Frequency and development of CNS involvement in Chinese children with hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2010 ; 54: 408-415
6. Janka GE. Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr. 1983 ; 140: 221-230
7. Huddle DC, Rosenblum JD, Diamond CK. CT and MR findings in familial erythrophagocytic lymphohistiocytosis. AJR Am J Roentgenol. 1994 ; 162: 1504-1505
8. Munoz Ruano MM, Castillo M. Brain CT and MR imaging in familial hemophagocytic lymphohistiocytosis. AJR Am J Roentgenol. 1998 ; 170: 802
9. Ozgen B, Karli-Oguz K, Sarikaya B, et al. Diffusion-weighted cranial MR imaging findings in a patient with hemophagocytic syndrome. AJNR Am J Neuroradiol. 2006 ; 27: 1312-1314
10. Chung TW. CNS involvement in hemophagocytic lymphohistiocytosis: CT and MR findings. Korean J Radiol. 2007 ; 8: 78-81
11. Peterson RA, Kuwabara T. Ocular manifestations of familial lymphohistiocytosis. Arch Ophthalmol. 1968 ; 79: 413-416
12. Park JK, Palexas GN, Streeten BW, Green WR. Ocular involvement in familial erythrophagocytic lymphohistiocytosis. Graefes Arch Clin Exp Ophthalmol. 1997 ; 235 (10). 647-652
13. Shinoda J, Murase S, Takenaka K, Sakai N. Isolated central nervous system hemophagocytic lymphohistiocytosis: case report. Neurosurgery. 2005 ; 56: E187 - E190
14. Goo HW, Weon YC. A spectrum of neuroradiological findings in children with hemophagocytic lymphohistiocytosis. Pediatr Radiol. 2007 ; 37: 1110-1117
15. Decaminada N, Cappellini M, Mortilla M, et al. Familial hemophagocytic lymphohistiocytosis: clinical and neuroradiological findings and review of the literature. Childs Nerv Syst. 2010 ; 26: 121-127