Serum nitric oxide synthase activity is a novel predictor of impaired vasorelaxation in rats

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 10, 2012, Pages 894-896

  Chan, Enoch ^a   Chan, J Y Y ^a   Wu, Jian Hong ^a   Wan, Chun Wai ^a   Leung, George Pak Heng ^b   Lee, Simon Ming Yuen ^c   Kwan, Yiu Wa ^d   Chan, Shun Wan ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^d UNIVERSITY OF MACAU   (Macao)

Author keywords

Cholesterol; Diagnostic; Nitric oxide synthase; Serum; Vasorelaxation

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL; NITRIC OXIDE SYNTHASE; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; MALE; NONHUMAN; RAT; VASODILATATION;

EID: 84866790789     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2012.05748.x     Document Type: Article

References (17)

1. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: Structure, function and inhibition. Biochem. J. 2001; 357: 593-615.
2. Abeywardena MY, Head RJ. Longchain n-3 polyunsaturated fatty acids and blood vessel function. Cardiovasc. Res. 2001; 52: 361-71.
3. Danser AHJ, Tom B, de Vries R, Saxena PR. l-NAME-resistant bradykinin-induced relaxation in porcine coronary arteries is NO-dependent: Effect of ACE inhibition. Br. J. Pharmacol. 2000; 131: 195-202.
4. Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors. FASEB J. 1989; 3: 2007-18.
5. Spieker LE, Sudano I, Hurlimann D et al. High-density lipoprotein restores endothelial function in hypercholesterolemic men. Circulation 2002; 105: 1399-402.
6. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem. J. 1994; 298: 249-58.
7. Avogaro A, Piarulli F, Valerio A et al. Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients. Diabetes 1997; 46: 1040-6.
8. Moshage H, Kok B, Huizenga JR, Jansen PL. Nitrite and nitrate determinations in plasma: A critical evaluation. Clin. Chem. 1995; 41: 892-6.
9. Leeson P, Thorne S, Donald A, Mullen M, Clarkson P, Deanfield J. Non-invasive measurement of endothelial function: Effect on brachial artery dilatation of graded endothelial dependent and independent stimuli. Heart 1997; 78: 22-7.
10. Vogel RA. Measurement of endothelial function by brachial artery flow-mediated vasodilation. Am. J. Cardiol. 2001; 88: 31-4.
11. Li Q, Wu JH, Guo DJ, Cheng HL, Chen SL, Chan SW. Suppression of diet-induced hypercholesterolemia by scutellarin in rats. Planta Med. 2009; 75: 1203-8.
12. Wan CW, Wong CN, Pin WK et al. Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-alpha in hypercholesterolemic rats induced with a high-cholesterol diet. Phytother. Res. 2012; Epub 6 June 2012; doi:10.1002/ptr4751.
13. Yan LP, Chan SW, Chan AS, Chen SL, Ma XJ, Xu HX. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sci. 2006; 79: 324-30.
14. Montezano AC, Touyz RM. Reactive oxygen species and endothelial function: Role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases. Basic Clin. Pharmacol. Toxicol. 2012; 110: 87-94.
15. Kang BPS, Mehta U, Bansal MP. Effect of diet induced hypercholesterolemia and selenium supplementation on nitric oxide synthase activity. Arch. Physiol. Biochem. 1997; 105: 603-6.
16. Diamant M, Tushuizen ME, Abid-Hussein MN, Hau CM, Böing AN, Sturk A, Nieuwland R. Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent. Thromb. Haemost. 2008; 100: 489-97.
17. Comparato C, Altana C, Bellosta S, Baetta R, Paoletti R, Corsini A. Clinically relevant pleiotropic effects of statins: Drug properties or effects of profound cholesterol reduction? Nutr. Metab. Cardiovasc. Dis. 2001; 11: 328-43.