Effects of fatty acids on cardioprotection by pre-ischaemic inhibition of the malate-aspartate shuttle

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 10, 2012, Pages 878-885

  Dalgas, Christian ^a,b   Povlsen, Jonas Agerlund ^a,b   Løfgren, Bo ^a,b   Erichsen, Sune Brinck ^a,b   Bøtker, Hans Erik ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Aminooxyacetate; Fatty acids; Ischaemia; Malate aspartate shuttle; Reperfusion

Indexed keywords

ALBUMIN; ASPARTIC ACID; GLUCOSE; LACTIC ACID; MALIC ACID; PALMITIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE OXIDATION; HEART; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALATE ASPARTATE CYCLE; MALE; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

AMINOOXYACETIC ACID; ANIMALS; ASPARTIC ACID; CARDIOTONIC AGENTS; FATTY ACIDS; GLUCOSE; HEART; HEMODYNAMICS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; LACTIC ACID; MALATES; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATION-REDUCTION; RATS; RATS, WISTAR;

EID: 84866788712     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2012.05749.x     Document Type: Article

References (27)

1. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol. Rev. 2010; 90: 207-58.
2. Di Lisa F, Bernardi P. Mitochondria and ischaemia-reperfusion injury of the heart: Fixing a hole. Cardiovasc. Res. 2006; 70: 191-9.
3. Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion: A target for cardioprotection. Cardiovasc. Res. 2004; 61: 372-85.
4. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischaemia: A delay of lethal cell injury in ischaemic myocardium. Circulation 1986; 74: 1124-36.
5. Javadov SA, Clarke S, Das M, Griffiths EJ, Lim KH, Halestrap AP. Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart. J. Physiol. 2003; 549: 513-24.
6. Safer B. The metabolic significance of the malate-aspartate cycle in heart. Circ. Res. 1975; 37: 527-33.
7. Rej R. Aminooxyacetate is not an adequate differential inhibitor of aspartate aminotransferase isoenzymes. Clin. Chem. 1977; 23: 1508-9.
8. Bunger R, Glanert S, Sommer O, Gerlach E. Inhibition by (aminooxy)acetate of the malate-aspartate cycle in the isolated working guinea-pig heart. Hoppe Seylers Z. Physiol. Chem. 1980; 361: 907-14.
9. Gonzalez-Mateos F, Gomez ME, Garcia-Salguero L, Sanchez V, Aragon JJ. Inhibition of glycolysis by amino acids in ascites tumor cells. Specificity and mechanism. J. Biol. Chem. 1993; 268: 7809-17.
10. Barron JT, Gu L, Parrillo JE. Malate-aspartate shuttle, cytoplasmic NADH redox potential, and energetics in vascular smooth muscle. J. Mol. Cell. Cardiol. 1998; 30: 1571-9.
11. Stottrup NB, Lofgren B, Birkler RD et al. Inhibition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection. Cardiovasc. Res. 2010; 88: 257-66.
12. Folmes CD, Sowah D, Clanachan AS, Lopaschuk GD. High rates of residual fatty acid oxidation during mild ischaemia decrease cardiac work and efficiency. J. Mol. Cell. Cardiol. 2009; 47: 142-8.
13. Occhipinti R, Somersalo E, Calvetti D. Astrocytes as the glucose shunt for glutamatergic neurons at high activity: An in silico study. J. Neurophysiol. 2009; 101: 2528-38.
14. Feuvray D, Plouet J. Relationship between structure and fatty acid metabolism in mitochondria isolated from ischaemic rat hearts. Circ. Res. 1981; 48: 740-7.
15. Gambert S, Vergely C, Filomenko R et al. Adverse effects of free fatty acid associated with increased oxidative stress in postischaemic isolated rat hearts. Mol. Cell. Biochem. 2006; 283: 147-52.
16. Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischaemic hearts by inhibiting glucose oxidation. J. Am. Coll. Cardiol. 2002; 39: 718-25.
17. Lopaschuk GD, Wambolt RB, Barr RL. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischaemic hearts. J. Pharmacol. Exp. Ther. 1993; 264: 135-44.
18. Liu B, Clanachan AS, Schulz R, Lopaschuk GD. Cardiac efficiency is improved after ischaemia by altering both the source and fate of protons. Circ. Res. 1996; 79: 940-8.
19. Carmeliet E. Cardiac ionic currents and acute ischaemia: From channels to arrhythmias. Physiol. Rev. 1999; 79: 917-1017.
20. O'Donnell JM, White LT, Lewandowski ED. Mitochondrial transporter responsiveness and metabolic flux homeostasis in postischaemic hearts. Am. J. Physiol. 1999; 277: H866-73.
21. Nielsen TT, Stottrup NB, Lofgren B, Botker HE. Metabolic fingerprint of ischaemic cardioprotection: Importance of the malate-aspartate shuttle. Cardiovasc. Res. 2011; 91: 382-91.
22. Terrand J, Papageorgiou I, Rosenblatt-Velin N, Lerch R. Calcium-mediated activation of pyruvate dehydrogenase in severely injured postischaemic myocardium. Am. J. Physiol. Heart Circ. Physiol. 2001; 281: H722-30.
23. McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischaemic rat hearts. Am. J. Physiol. 1990; 259: H1079-85.
24. Finegan BA, Lopaschuk GD, Gandhi M, Clanachan AS. Ischaemic preconditioning inhibits glycolysis and proton production in isolated working rat hearts. Am. J. Physiol. 1995; 269: H1767-75.
25. Greenhouse WV, Lehninger AL. Occurrence of the malate-aspartate shuttle in various tumor types. Cancer Res. 1976; 36: 1392-6.
26. Kakhniashvili D, Mayor JA, Gremse DA, Xu Y, Kaplan RS. Identification of a novel gene encoding the yeast mitochondrial dicarboxylate transport protein via overexpression, purification, and characterization of its protein product. J. Biol. Chem. 1997; 272: 4516-21.
27. Robinson BH, Williams GR, Halperin ML, Leznoff CC. Inhibitors of dicarboxylate and tricarboxylate transporting systems of rat liver mitochondria. J. Membr. Biol. 1972; 7: 391-401.