Optimization of the solid-phase synthesis of [18F] radiolabeled peptides for positron emission tomography

Applied Radiation and Isotopes

Volumn 70, Issue 12, 2012, Pages 2720-2729

  White, Jason B ^a   Hausner, Sven H ^a,c   Carpenter, Richard D ^a   Sutcliffe, Julie L ^a,b,c  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fluorine 18; Peptides; Positron emission tomography; Radiolabeling; Solid phase

Indexed keywords

COUPLING REAGENTS; EFFICIENT SYNTHESIS; FLUORINE-18; FLUOROBENZOIC ACIDS; HIGH-PURITY; IN-VIVO; IN-VIVO IMAGING; INTEGRINS; MODEL PEPTIDES; MOLECULAR PROBES; OPTIMIZED CONDITIONS; RADIOCHEMICAL YIELD; RADIOLABELING; SOLID PHASE PEPTIDE SYNTHESIS; SOLID PHASE SYNTHESIS; SOLID-PHASE; STANDARD CONDITIONS;

AMINO ACIDS; FLUORINE; MOLECULAR IMAGING; OPTIMIZATION; POSITRON EMISSION TOMOGRAPHY;

PEPTIDES;

4 FLUOROBENZOIC ACID POLYETHYLENE GLYCOL POLYSTYRENE 28 ASPARAGINYLALANYLVALYLPROLYLASPARAGINYLLEUCYLARGINYLGLYCYLASPARTYLLEUCYLGLUTAMYLVALYLALANYLGLUTAMYLLYSYLVALYLALANYLARGINYLTHREONINE; ALPHAVBETA6 INTEGRIN; TRACER; UNCLASSIFIED DRUG;

ARTICLE; HEATING; IN VIVO STUDY; ISOTOPE LABELING; MOLECULAR IMAGING; MOLECULAR PROBE; PEPTIDE SYNTHESIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; RELIABILITY; SOLID PHASE SYNTHESIS; STANDARDIZATION;

FLUORINE RADIOISOTOPES; ISOTOPE LABELING; OLIGOPEPTIDES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SOLID-PHASE SYNTHESIS TECHNIQUES;

EID: 84866786863     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2012.08.003     Document Type: Article

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