Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice

Neuroscience Letters

Volumn 527, Issue 2, 2012, Pages 110-114

  Liang, Yajie ^a   Lin, Sen ^b   Zou, Liyun ^a   Zhou, Hongli ^b   Zhang, Jiqiang ^a   Su, Bingyin ^b   Wan, Ying ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHENGDU MEDICAL COLLEGE   (China)

Author keywords

Brain; Inflammation; Microglia; QPCR; Rab GTPase

Indexed keywords

BETA ACTIN; HYPOXIA INDUCIBLE FACTOR 1; INTERLEUKIN 1BETA; MESSENGER RNA; RAB PROTEIN; RAB11 PROTEIN; RAB11B PROTEIN; RAB20 PROTEIN; RAB27A PROTEIN; RAB27B PROTEIN; RAB32 PROTEIN; RAB33A PROTEIN; RAB37 PROTEIN; RAB3C PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE BRAIN DISEASE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; ENCEPHALITIS; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; UPREGULATION;

ACUTE DISEASE; ANIMALS; ANIMALS, NEWBORN; BRAIN; CELL COUNT; ENCEPHALITIS; GENE EXPRESSION PROFILING; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; POLYMERASE CHAIN REACTION; RAB GTP-BINDING PROTEINS;

EID: 84866765486     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.08.039     Document Type: Article

References (28)

1. Alto N.M., Soderling J., Scott J.D. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. Journal of Cell Biology 2002, 158:659-668.
2. Amillet J.M., Ferbus D., Real F.X., Antony C., Muleris M., Gress T.M., Goubin G. Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. Human Pathology 2006, 37:256-263.
3. Curtis L.M., Gluck S. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Nephron Physiology 2005, 100:31-42.
4. Das Sarma J., Kaplan B.E., Willemsen D., Koval M. Identification of rab20 as a potential regulator of connexin 43 trafficking. Cell Communication and Adhesion 2008, 15:65-74.
5. Dheen S.T., Kaur C., Ling E.A. Microglial activation and its implications in the brain diseases. Current Medicinal Chemistry 2007, 14:1189-1197.
6. Fukuda M. Regulation of secretory vesicle traffic by Rab small GTPases. Cellular and Molecular Life Sciences 2008, 65:2801-2813.
7. Fukuda M. Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. Journal of Biochemistry 2005, 137:9-16.
8. Gutierrez M.G., Mishra B.B., Jordao L., Elliott E., Anes E., Griffiths G. NF-kappaB activation controls phagolysosome fusion-mediated killing of mycobacteria by macrophages. Journal of Immunology 2008, 181:2651-2663.
9. Hackenbeck T., Huber R., Schietke R., Knaup K.X., Monti J., Wu X., Klanke B., Frey B., Gaipl U., Wullich B., Ferbus D., Goubin G., Warnecke C., Eckardt K.U., Wiesener M.S. The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia. Biochimica et Biophysica Acta 2011, 1813:1-13.
10. Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nature Neuroscience 2007, 10:1387-1394.
11. Iezzi M., Escher G., Meda P., Charollais A., Baldini G., Darchen F., Wollheim C.B., Regazzi R. Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells. Molecular Endocrinology 1999, 13:202-212.
12. Janga S.C., Mittal N. Construction, structure and dynamics of post-transcriptional regulatory network directed by RNA-binding proteins. Advances in Experimental Medicine and Biology 2011, 722:103-117.
13. Krause D.L., Müller N. Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease. International Journal of Alzheimer's Disease 2010, 2010:1-9. Article ID 732806. 10.4061/2010/732806.
14. Kuschel A., Simon P., Tug S. Functional regulation of HIF-1alpha under normoxia-is there more than post-translational regulation?. Journal of Cellular Physiology 2012, 227:514-524.
15. Liang Y., Li S., Wen C., Zhang Y., Guo Q., Wang H., Su B. Intrastriatal injection of colchicine induces striatonigral degeneration in mice. Journal of Neurochemistry 2008, 106:1815-1827.
16. Mori R., Ikematsu K., Kitaguchi T., Kim S.E., Okamoto M., Chiba T., Miyawaki A., Shimokawa I., Tsuboi T. Release of TNF-alpha from macrophages is mediated by small GTPase Rab37. European Journal of Immunology 2011, 41:3230-3239.
17. Murray R.Z., Kay J.G., Sangermani D.G., Stow J.L. A role for the phagosome in cytokine secretion. Science 2005, 310:1492-1495.
18. Ng E.L., Tang B.L. Rab, GTPases and their roles in brain neurons and glia. Brain Research Reviews 2008, 58:236-246.
19. Oh Y.T., Lee J.Y., Yoon H., Lee E.H., Baik H.H., Kim S.S., Ha J., Yoon K.S., Choe W., Kang I. Lipopolysaccharide induces hypoxia-inducible factor-1 alpha mRNA expression and activation via NADPH oxidase and Sp1-dependent pathway in BV2 murine microglial cells. Neuroscience Letters 2008, 431:155-160.
20. Pellagatti A., Esoof N., Watkins F., Langford C.F., Vetrie D., Campbell L.J., Fidler C., Cavenagh J.D., Eagleton H., Gordon P., Woodcock B., Pushkaran B., Kwan M., Wainscoat J.S., Boultwood J. Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. British Journal of Haematology 2004, 125:576-583.
21. Saura J., Tusell J.M., Serratosa J. High-yield isolation of murine microglia by mild trypsinization. Glia 2003, 44:183-189.
22. Smith J.A., Das A., Ray S.K., Banik N.L. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Research Bulletin 2012, 87:10-20.
23. Touchot N., Chardin P., Tavitian A. Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. Proceedings of the National Academy of Sciences of the United States of America 1987, 84:8210-8214.
24. Wang Y., Chen T., Han C., He D., Liu H., An H., Cai Z., Cao X. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood 2007, 110:962-971.
25. Wasmeier C., Romao M., Plowright L., Bennett D.C., Raposo G., Seabra M.C. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. Journal of Cell Biology 2006, 175:271-281.
26. Wu C., Orozco C., Boyer J., Leglise M., Goodale J., Batalov S., Hodge C.L., Haase J., Janes J., Huss J.W., Su A.I. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biology 2009, 10:R130.
27. Yokoyama K., Kaji H., He J., Tanaka C., Hazama R., Kamigaki T., Ku Y., Tohyama K., Tohyama Y. Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes. Journal of Biological Chemistry 2011, 286:5375-5382.
28. Zou L., Zhou J., Zhang J., Li J., Liu N., Chai L., Li N., Liu T., Li L., Xie Z., Liu H., Wan Y., Wu Y. The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:15801-15806.