Antibody-Drug Conjugates for Targeted Cancer Therapy

Annual Reports in Medicinal Chemistry

Volumn 47, Issue , 2012, Pages 349-366

  Goldmacher, Victor S ^a   Chittenden, Thomas ^a   Chari, Ravi V J ^a   Kovtun, Yelena V ^a   Lambert, John M ^a  

^a IMMUNOGEN INC   (United States)

Author keywords

ADC; Antibody drug conjugate; Auristatin; Calicheamicin; CC 1065; Duocarmycin; Linker; Maytansinoid; Monoclonal antibody; Targeted therapy; Tumor associated antigen

Indexed keywords

EID: 84866750548     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-396492-2.00023-0     Document Type: Chapter

References (48)

1. Erickson H.K., Park P.U., Widdison W.C., Kovtun Y.V., Garrett L.M., Hoffman K., Lutz R.J., Goldmacher V.S., Blattler W.A. Cancer Res. 2006, 66:4426.
2. Carter P., Smith L., Ryan M. Endocr. Relat. Cancer. Cancer 2004, 11:659.
3. Xie H., Blattler W.A. Expert Opin. Biol. Ther. 2006, 6:281.
4. Qin, A.; Mastico, R.A.; Lutz, R.J.; O'Keeffe, J.; Zildjian, S.; Mita, A.C.; Phan, A.T.; Tolcher, A.W. American Society of clinical oncology annual meeting proceedings, 2008, 3066.
5. Vater A.V., Goldmacher V.S. Macromolecular Anticancer Therapeutics 2009, 331. Springer, New York, NY. L.H. Reddy, P. Couvreur (Eds.).
6. Ross S., Spencer S.D., Holcomb I., Tan C., Hongo J., Devaux B., Rangell L., Keller G.A., Schow P., Steeves R.M., Lutz R.J., Frantz G., Hillan K., Peale F., Tobin P., Eberhard D., Rubin M.A., Lasky L.A., Koeppen H. Cancer Res. 2002, 62:2546.
7. Blanc V., Bousseau A., Caron A., Carrez C., Lutz R.J., Lambert J.M. Clin. Cancer Res. 2011, 17:6448.
8. Deckert J., Chicklas S., Yi Y., Li M., Pinkas J., Chittenden T., Lutz R.J., Park P.U. ASH Annu. Meeting Abstr. 2011, 118:3726.
9. Dornan D., Bennett F., Chen Y., Dennis M., Eaton D., Elkins K., French D., Go M.A., Jack A., Junutula J.R., Koeppen H., Lau J., McBride J., Rawstron A., Shi X., Yu N., Yu S.F., Yue P., Zheng B., Ebens A., Polson A.G. Blood 2009, 114:2721.
10. Junttila T.T., Li G., Parsons K., Lewis Phillips G., Sliwkowski M.X. Breast Cancer Res. Treat. 2011, 128:347.
11. Goldmacher V.S., Blattler W.A., Lambert J.M., Chari R.V.J. Biomedical Aspects of Drug Targeting 2002, 291. Kluwer Academic Publishers, Boston/Dordrecht/London. V. Muzykantov, V. Torchilin (Eds.).
12. Singh R., Erickson H.K. Therapeutic Antibodies: Methods and Protocols 2009, Vol. 525:445. Humana Press, Totowa, NJ. A.S. Dimitrov (Ed.).
13. Chari R.V. Acc. Chem. Res. 2008, 41:98.
14. Burke P.J., Senter P.D., Meyer D.W., Miyamoto J.B., Anderson M., Toki B.E., Manikumar G., Wani M.C., Kroll D.J., Jeffrey S.C. Bioconjugate Chem. 2009, 20:1242.
15. Oroudjev E., Lopus M., Wilson L., Audette C., Provenzano C., Erickson H., Kovtun Y., Chari R., Jordan M.A. Mol. Cancer Ther. 2010, 9:2700.
16. Drewinko B., Patchen M., Yang L.Y., Barlogie B. Cancer Res. 1981, 41:2328.
17. Widdison W.C., Wilhelm S.D., Cavanagh E.E., Whiteman K.R., Leece B.A., Kovtun Y., Goldmacher V.S., Xie H., Steeves R.M., Lutz R.J., Zhao R., Wang L., Blattler W.A., Chari R.V. J. Med. Chem. 2006, 49:4392.
18. Kovtun Y.V., Audette C.A., Mayo M.F., Jones G.E., Doherty H., Maloney E.K., Erickson H.K., Sun X., Wilhelm S., Ab O., Lai K.C., Widdison W.C., Kellogg B., Johnson H., Pinkas J., Lutz R.J., Singh R., Goldmacher V.S., Chari R.V. Cancer Res. 2010, 70:2528.
19. Lewis Phillips G.D., Li G., Dugger D.L., Crocker L.M., Parsons K.L., Mai E., Blattler W.A., Lambert J.M., Chari R.V., Lutz R.J., Wong W.L., Jacobson F.S., Koeppen H., Schwall R.H., Kenkare-Mitra S.R., Spencer S.D., Sliwkowski M.X. Cancer Res. 2008, 68:9280.
20. Doronina S.O., Toki B.E., Torgov M.Y., Mendelsohn B.A., Cerveny C.G., Chace D.F., DeBlanc R.L., Gearing R.P., Bovee T.D., Siegall C.B., Francisco J.A., Wahl A.F., Meyer D.L., Senter P.D. Nat. Biotechnol. 2003, 21:778.
21. Doronina S.O., Mendelsohn B.A., Bovee T.D., Cerveny C.G., Alley S.C., Meyer D.L., Oflazoglu E., Toki B.E., Sanderson R.J., Zabinski R.F., Wahl A.F., Senter P.D. Bioconjugate Chem. 2006, 17:114.
22. Hamblett K.J., Senter P.D., Chace D.F., Sun M.M., Lenox J., Cerveny C.G., Kissler K.M., Bernhardt S.X., Kopcha A.K., Zabinski R.F., Meyer D.L., Francisco J.A. Clin. Cancer Res. 2004, 10:7063.
23. Alley S.C., Benjamin D.R., Jeffrey S.C., Okeley N.M., Meyer D.L., Sanderson R.J., Senter P.D. Bioconjugate Chem. 2008, 19:759.
24. Doronina S.O., Bovee T.D., Meyer D.W., Miyamoto J.B., Anderson M.E., Morris-Tilden C.A., Senter P.D. Bioconjugate Chem. 2008, 19:1960.
25. DiJoseph J.F., Armellino D.C., Boghaert E.R., Khandke K., Dougher M.M., Sridharan L., Kunz A., Hamann P.R., Gorovits B., Udata C., Moran J.K., Popplewell A.G., Stephens S., Frost P., Damle N.K. Blood 2004, 103:1807.
26. Hamann P.R., Hinman L.M., Beyer C.F., Greenberger L.M., Lin C., Lindh D., Menendez A.T., Wallace R., Durr F.E., Upeslacis J. Bioconjugate Chem. 2005, 16:346.
27. Hamann P.R., Hinman L.M., Beyer C.F., Lindh D., Upeslacis J., Flowers D.A., Bernstein I. Bioconjugate Chem. 2002, 13:40.
28. Boger D.L., Yun W., Han N., Johnson D.S. Bioorg. Med. Chem. 1995, 3:611.
29. Zhao R.Y., Erickson H.K., Leece B.A., Reid E.E., Goldmacher V.S., Lambert J.M., Chari R.V. J. Med. Chem. 2012, 55:766.
30. King, D.; Terrett, J.; Cardarelli, P.; Pan, C.; Rao, C.; Gangwar, S.; Deshpande, S.; Vangipuram, R.; Passmore, D.; Mirjolet, J.F.; Bichat, F. AACR meeting abstracts, Abstract 4057, San Diego, CA, April, 2008.
31. Junutula J.R., Raab H., Clark S., Bhakta S., Leipold D.D., Weir S., Chen Y., Simpson M., Tsai S.P., Dennis M.S., Lu Y., Meng Y.G., Ng C., Yang J., Lee C.C., Duenas E., Gorrell J., Katta V., Kim A., McDorman K., Flagella K., Venook R., Ross S., Spencer S.D., Lee Wong W., Lowman H.B., Vandlen R., Sliwkowski M.X., Scheller R.H., Polakis P., Mallet W. Nat. Biotechnol. 2008, 26:925.
32. Kovtun Y.V., Goldmacher V.S. Cancer Lett. 2007, 255:232.
33. Zhao R.Y., Wilhelm S.D., Audette C., Jones G., Leece B.A., Lazar A.C., Goldmacher V.S., Singh R., Kovtun Y., Widdison W.C., Lambert J.M., Chari R.V.J. J. Med. Chem. 2011, 54:3606.
34. Hurvitz, S.; Dirix, L.; Kocsis, J.; Gianni, L.; Lu, J.; Vinholes, J.; Song, C.; Tong, B.; Chu, Y.W.; Perez, E.A. The 2011 European multidisciplinary cancer congress abstracts, Abstract 5001, 2011.
35. Burris H.A., Rugo H.S., Vukelja S.J., Vogel C.L., Borson R.A., Limentani S., Tan-Chiu E., Krop I.E., Michaelson R.A., Girish S., Amler L., Zheng M., Chu Y.W., Klencke B., O'Shaughnessy J.A. J. Clin. Oncol. 2011, 29:398.
36. Tse K.F., Jeffers M., Pollack V.A., McCabe D.A., Shadish M.L., Khramtsov N.V., Hackett C.S., Shenoy S.G., Kuang B., Boldog F.L., MacDougall J.R., Rastelli L., Herrmann J., Gallo M., Gazit-Bornstein G., Senter P.D., Meyer D.L., Lichenstein H.S., LaRochelle W.J. Clin. Cancer Res. 2006, 12:1373.
37. Rose A.A., Grosset A.A., Dong Z., Russo C., Macdonald P.A., Bertos N.R., St-Pierre Y., Simantov R., Hallett M., Park M., Gaboury L., Siegel P.M. Clin. Cancer Res. 2010, 16:2147.
38. Hamid O., Sznol M., Pavlick A.C., Kluger H.M., Kim K.B., Boasberg P.D., Simantov R., Davis T.A., Crowley E., Hwu P. ASCO Meeting Abstr. 2010, 28:8525.
39. Saleh M.N., Bendell J.C., Rose A., Siegel P., Hart L.L., Sirpal S., Jones S.F., Crowley E., Simantov R., Vahdat L.T. ASCO Meeting Abstr. 2010, 28:1095.
40. Tassone P., Gozzini A., Goldmacher V., Shammas M.A., Whiteman K.R., Carrasco D.R., Li C., Allam C.K., Venuta S., Anderson K.C., Munshi N.C. Cancer Res. 2004, 64:4629.
41. Roy D.C., Ouellet S., Le Houillier C., Ariniello P.D., Perreault C., Lambert J.M. J. Natl. Cancer Inst. 1996, 88:1136.
42. Wall P.J., O'Brien M., Fossella F., Shah M.H., Clinch Y., O'Keeffe J., Qin A., O'Leary J., Lorigan P. Ann. Oncol. 2010, 21:536P.
43. Chanan-Khan A., Wolf J.L., Garcia J., Gharibo M., Jagannath S., Manfredi D., Sher T., Martin C., Zildjian S.H., O'Leary J., Vescio R. ASH Annu. Meeting Abstr. 2010, 116:1962.
44. Berdeja J.G., Ailawadhi S., Weitman S.D., Zildjian S., O'Leary J.J., O'Keeffe J., Guild R., Whiteman K., Chanan-Khan A.A.A. ASCO Meeting Abstr. 2011, 29:8013.
45. Al-Katib A.M., Aboukameel A., Mohammad R., Bissery M.C., Zuany-Amorim C. Clin. Cancer Res. 2009, 15:4038.
46. Coiffier B., Ribrag V., Dupuis J., Tilly H., Haioun C., Morschhauser F., Lamy T., Copie-Bergman C., Brehar O., Houot R., Lambert J.M., Morarui-Zamfir R. ASCO Meeting Abstr. 2011, 29:8017.
47. Younes, A.; Gordon, L.; Kim, S.; Romaguera, J.; Copeland, A.R.; de Castro Farial, S.; Kwak, L.; Fayad, L.; Hagemeister, F.; Fanale, M.; Lambert, J.; Bagulho, T.; Morariu-Zamfir, R. 51st ASH annual meeting, New Orleans, LA, December, 2009.
48. DiJoseph J.F., Dougher M.M., Kalyandrug L.B., Armellino D.C., Boghaert E.R., Hamann P.R., Moran J.K., Damle N.K. Clin. Cancer Res. 2006, 12:242.