TLR4 mRNA levels as tools to estimate risk for early posttransplantation kidney graft dysfunction

Transplantation

Volumn 94, Issue 6, 2012, Pages 589-595

  Andrade Oliveira, Vinicius ^a,b   Campos, Erika F ^a,b   Goncalves Primo, Amador ^a   Grenzi, Patricia C ^a,b   Medina Pestana, Jose O ^b,c   Tedesco Silva, Helio ^c   Gerbase Delima, Maria ^a,b  

^a Instituto de Imunogenética Associação Fundo de Incentivo À Pesquisa   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c HOSPITAL DO RIM E HIPERTENSÃO   (Brazil)

Author keywords

Delayed graft function; Innate immunity; Ischemia reperfusion; Kidney renal transplantation; TLR4

Indexed keywords

AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; MESSENGER RNA; MYCOPHENOLIC ACID; MYELOID DIFFERENTIATION FACTOR 88; PREDNISONE; THYMOCYTE ANTIBODY; TOLL LIKE RECEPTOR 4;

ACCURACY; ADULT; ARTICLE; BLOOD ANALYSIS; CADAVER DONOR; CONTROLLED STUDY; GENE; GENE EXPRESSION; GRAFT RECIPIENT; HUMAN; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MYD88 GENE; POSTOPERATIVE PERIOD; PREDICTION; PREDICTIVE VALUE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; RENAL GRAFT DYSFUNCTION; RISK ASSESSMENT; TLR4 GENE; URINALYSIS;

ADULT; AGED; BIOLOGICAL MARKERS; BIOPSY; DELAYED GRAFT FUNCTION; HUMANS; IMMUNITY, INNATE; KIDNEY; KIDNEY TRANSPLANTATION; LIVING DONORS; MIDDLE AGED; MYELOID DIFFERENTIATION FACTOR 88; PREDICTIVE VALUE OF TESTS; REAL-TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTORS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TREATMENT OUTCOME;

EID: 84866743569     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31825db680     Document Type: Article

References (36)

1. Perico N, Cattaneo D, Sayegh MH, et al. Delayed graft function in kidney transplantation. Lancet 2004; 364: 181-4.
2. Harada KM, Mandia-Sampaio EL, de Sandes-Freitas TV, et al. Risk factors associated with graft loss and patient survival after kidney transplantation. Transplant Proc 2009; 41: 366-7.
3. Yarlagadda SG, Coca SG, Formica RN Jr, et al. Association between delayed graft function and allograft and patient survival: a systematic review and meta-Analysis. Nephrol Dial Transplant 2009; 24: 103-9.
4. Englesbe MJ, Ads Y, Cohn JA, et al. The effects of donor and recipient practices on transplant center finances. Am J Transplant 2008; 8: 58-6.
5. Matas AJ, Gillingham KJ, Elick BA, et al. Risk factors for prolonged hospitalization after kidney transplants. Clin Transplant 1997; 11: 25-9.
6. Giral-Classe M, Hourmant M, Cantarovich D, et al. Delayed graft function of more than six days strongly decreases long-Term survival of transplanted kidneys. Kidney Int 1998; 54: 97-2.
7. Kayler LK, Magliocca J, Zendejas I, et al. Impact of cold ischemia time on graft survival among ECD transplant recipients: a paired kidney analysis. Am J Transplant 2011; 11: 264-7.
8. Bouma HR, Ploeg RJ, Schuurs TA. Signal transduction pathways involved in brain deathYinduced renal injury. Am J Transplant 2009; 9: 98-9.
9. Kayler LK, Srinivas TR, Schold JD. Influence of CIT-induced DGF on kidney transplant outcomes. Am J Transplant 2011; 11: 265-7.
10. Gluba A, Banach M, Hannam S, et al. The role of Toll-like receptors in renal diseases. Nat Rev Nephrol 2010; 6: 22-4.
11. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001; 1: 13-5.
12. Matzinger P. The danger model: a renewed sense of self. Science 2002; 296: 30-1.
13. Anders HJ, Schlondorff D. Toll-like receptors: emerging concepts in kidney disease. Curr Opin Nephrol Hypertens 2007; 16: 17-7.
14. Land WG. The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation. Transplantation 2005; 79: 50-5.
15. Obhrai J, Goldstein DR. The role of Toll-like receptors in solid organ transplantation. Transplantation 2006; 81: 49-7.
16. Anders HJ, Banas B, Schlondorff D. Signaling danger: Toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 2004; 15: 85-4.
17. Wolfs TG, Buurman WA, van Schadewijk A, et al. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-F and TNF-> mediated up-regulation during inflammation. J Immunol 2002; 168: 128-6.
18. O'Neill LA, Bowie AG. The family of five: TIR-domainYcontaining adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007; 7: 35-3.
19. Kim BS, Lim SW, Li C, et al. Ischemia-reperfusion injury activates innate immunity in rat kidneys. Transplantation 2005; 79: 137-0.
20. Wu H, Chen G, Wyburn KR, et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 2007; 117: 284-7.
21. Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 18-7.
22. Ducloux D, Deschamps M, Yannaraki M, et al. Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney Int 2005: 67: 245-4.
23. Fekete A, Viklicky O, Hubacek JA, et al. Association between heat shock protein 70s and Toll-like receptor polymorphisms with longterm renal allograft survival. Transpl Int 2006; 19: 19-0.
24. Krüger B, Krick S, Dhillon N, et al. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci U S A 2009; 106: 339-0.
25. Palmer SM, Burch LH, Mir S, et al. Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Clin Transplant 2006; 20: 3-0.
26. Hall IE, Yarlagadda SG, Coca SG, et al. IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J Am Soc Nephrol 2009; 21: 18-9.
27. Flechner SM, Kurian SM, Head SR, et al. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant 2004; 4: 147-5.
28. Paragas N, Qiu A, Zhang Q, et al. The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat Med 2011; 17: 21-6.
29. Muzio M, Bosisio D, Polentarutti N, et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol 2000; 164: 599-8.
30. Sabroe I, Dower SK, Whyte MK. The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis 2005; 41: S42-1.
31. Shigeoka AA, Holscher TD, King AJ, et al. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J Immunol 2007; 178: 625-2.
32. Jiang N, Zhang X, Zheng X, et al. Targeted gene silencing of TLR4 using liposomal nanoparticles for preventing liver ischemia reperfusion injury. Am J Transplant 2011; 11: 183-5.
33. Port FK, Bragg-Gresham JL, Metzger RA, et al. Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors. Transplantation 2002; 74: 128-1.
34. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 71-3.
35. Li B, Hartono C, Ding R, et al. Noninvasive diagnosis of renal-Allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med 2001; 344: 94-7.
36. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-Time quantitative PCR and the 2(-Delta Delta C(T))method. Methods 2001; 25: 40-2.