Effect of chronic exposure to aspartame on oxidative stress in brain discrete regions of albino rats

Journal of Biosciences

Volumn 37, Issue 4, 2012, Pages 679-688

  Iyyaswamy, Ashok ^a   Rathinasamy, Sheeladevi ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Aspartame; Blood methanol; Free radical; Oxidative stress; Rat folate deficient model

Indexed keywords

ASPARTAME; CATALASE; CORTICOSTERONE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; METHANOL; METHOTREXATE; SUPEROXIDE DISMUTASE; THIOL;

BLOOD; BRAIN; ENZYME; FREE RADICAL; METABOLISM; METABOLITE; METHANOL; RODENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN REGION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME ACTIVITY; LIPID PEROXIDATION; LONG TERM EXPOSURE; MALE; METABOLISM; NONHUMAN; OXIDATIVE STRESS; RAT; WISTAR ALBINO GLAXO RAT;

ANIMALS; ASPARTAME; BRAIN; FREE RADICALS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; MALE; METHANOL; METHOTREXATE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

ANIMALIA; RATTUS;

EID: 84866736954     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-012-9236-0     Document Type: Article

References (62)

1. Akyol O, Herken H and Uz E 2002 The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients. The possible role of oxidant/antiox-idant imbalance. Prog. Neuropsychopharmacol. Biol. Psychiat. 26 995-1005
2. Leon AS, Hunninghake DB, Bell C, Rassin DK and Tephly TR 1989 Safety of Long-term Large Doses of Aspartame. Arch. Intern. Med. 149 2318-2324
3. Sinha AK 1972 Calorimetric assay of catalase. Anal. Biochem. 47 389-394
4. Barlow-Walden LR, Reiter RJ, Abe M, Pablos M, Menendez-Pelaez A, Chen LD and Poeggeler B 1995 Melatonin stimulates brain glutathione peroxidase activity. Neurochem. Int. 26 497-502
5. Coulombe RA and Sharma RP 1986 Neuro biochemical alterations induced by the artificial sweetener aspartame (NutraSweet). Toxicol. Appl. Pharmacol. 83 79-85
6. Dailey JW, Lasley SM, Burger RL, Bettendorf AF, Mishra PK and Jobe PC 1991 Amino acids, monoamines and audiogenic seizures in genetically epilepsy-prone rats: effects of aspartame. Epilepsy Res. 8 122-133
7. Diomede L, Romano M, Guiso G, Caccia S, Nava S and Salmona M 1991 Interspecies and interstrain studies on the increased susceptibility to metrazol-induced convulsions in animals given aspartame. Food Chem. Toxicol. 29 101-106
8. Dorman DC, Moss OR, Farris GM, Janszen D, Bond JA and Medinsky MA 1994 Pharmacokinetics of inhaled methanol and methanol derived formate in normal and folate deficiency cynomolgus monkeys. Toxicol. Appl. Pharmacol. 128 229-238
9. Dringen R 2000 Metabolism and functions of glutathione in brain. Prog Neurobiol. 62 649
10. Eells JT, Black KA, Makar AB, Tedford CE, and Tephly TR 1982 The regulation of one-carbon oxidation in the rat by nitrous oxide and methionine. Arch. Biochem. Biophys. 219 316-326
11. Eells JT, Black KA, Tedford CE, and Tephly TR 1983 Methanol toxicity in the monkey: effects of nitrous oxide and methionine. J. Pharmacol. Exp. Ther. 227 349-353
12. Eells JT, Henry MM, Lewandowski MF, Seme MT and Murray TG 2000 Development and characterization of a rodent model of methanol-induced retinal and optic nerve toxicity. Neurotoxicol. Rev. 21 321-330
13. Feldman S and Conforti N 1980 Participation of dorsal hippocampus in the glucocorticoids feedback effect on adrenocortical activity. Neuroendocrinology 30 52-55
14. Fernstrom JD, Fernstrom MH and Gillis MA 1983 Acute effects of aspartame on large neutral amino acids and monoamines in rat brain. Life Sci. 32 1651-1658
15. Floyd RA and Carney JM 1992 Free radical damage to protein and DNA: mechanism involved and relevant observation on brain undergoing oxidative stress. Ann. Neurol. 32 S22-S27
16. Garriga MM and Metcalfe DD 1988 Aspartame intolerance. Annal. Allergy 61 63-69
17. Glowinski J and Iverson LL 1996 Regional studies of catechol-amines in the rat brain. J. Neurochem. 13 655-669
18. Goerss AL, Wagner GC and Hill WL 2000 Acute effects of aspartame on aggression and neuro chemistry of rats. Life Sci. 67 1325-1329
19. Gombos K, Varjas T, Orsós Z, Polyák E, Peredi J, Varga Z, Nowrasteh G, Mucsi G and Ember I 2007 The effect of aspartame administration on oncogene and suppressor gene expressions. In Vivo 21 89-92
20. Gonzalez-Quevedo A, Obregon F, Urbina M, Rousso T and Lima L 2002 Effects of chronic methanol administration on amino acid and monoamines in retina, optic nerve, and brain of the rat. Toxicol. Appl. Pharmacol. 185 77-84
21. Goodman J and Tephly TR 1968 The role of hepatic microbody and soluble oxidases in the peroxidation of methanol in the rat and monkey. Mol. Pharmacol. 4 492-501
22. Haschemeyer RH and Haschemeyer AEV 1973 Proteins: A guide to study by physical and chemical methods vol I (New York: John Wiley and Sons) pp 1-30
23. Mourad IM and Noor NA 2011 Aspartame (a widely used artificial sweetener) and oxidative stress in the rat cerebral cortex. Int. J. Pharm. Biomed. Sci. 2 4-10
24. Jeganathan PS and Namasivayam A 1998 Methanol induced biogenic amine changes in discrete areas of rat brain: Role of simultaneous ethanol administration. Indian J. Physiol. Pharmacol. 32 1-10
25. Johns DR 1986 Migraine provoked by aspartame. New Engl. J. Med. 315 456
26. Johlin FC, Fortman CS, Nghiem DD and Tephly TR 1987 Studies on the role of folic acid and folate-dependent enzymes in human methanol poisoning. Mol. Pharmacol. 31 557-561
27. Jones DJ, Eklow L, Thor H and Orrenius S 1981 Metabolism of hydrogen peroxide in isolated hepatocytes: relative contribution of catalase and glutathione peroxidase in decomposition of endogenous generated H2O2. Arch. Biochem. Biophys. 210 505-516
28. Keyhani J and Keyhani E 1980 EPR study of effect of formate on cytochrome c oxidase. Biochem. Biophys. Res. Commun. 92 327-333
29. Kono Y and Fridorich I 1982 Superoxide radical inhibits catalase. J. Biol. Chem. 257 5751-5754
30. Kruse JA 1992 Methanol poisoning. Intensive Care Med. 18 391-397
31. Labra-Ruiz NA, Calderon-Guzman D, Vences-Mejia A, Hernandez-Martinez N, Gardenaarduno J and Dorado-Gonzalez V 2007 Effect of aspartame on the biogenic amines in rat brain. Epidemiology 18 (5) S90-S91
32. Lee EW, Garner CD and Terzo TS 1994 Animal model for the study of methanol toxicity: comparison of folate-reduced rat responses with published monkey data. J. Toxicol. Environ. Health 41 71-82
33. Maher TJ and Wurtman RJ 1987 Possible neurologic effects of aspartame, a widely used food additive. Environ. Health Perspect. 75 3-57
34. Makar AB, Tephly TR, Sahin G and Osweiler G 1990 Formate metabolism in young swine. Toxicol. Appl. Pharmacol. 105 315-320
35. Marklund S and Marklund G 1974 Involvement of the Superoxide anion radical in the auto oxidation of Pyrogallol and a convenient assay for superoxide dismntase. J. Biochem. 47 469-474
36. Mattingly D 1962 A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J. Clin. Pathol. 15 374
37. McMartin KE, Martin-Amat G, Noker PE and Tephly TR 1978 Lack of a role for formaldehyde in methanol poisoning in the monkey. Biochem. Pharm. 28 645-649
38. Moron MS, Depierre JW and Mannervik B 1979 Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim. Biophys. Acta 582 67-78
39. Newsome RL 1986 Sweeteners: Nutritive and non-nutritive; in The Scientific status summaries of the Institute of Food Technologies Expert Panel on Food Safety and Nutrition (Chicago: Institutive of Food Technologies)
40. Nikolaos P, George Z, Nikolaos TP, Christos DG, Fevronia A and Nikolaos AM 2004 Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure. Neurosci. Lett. 357 83-86
41. Oberly LW and Oberly TD 1986 Free radicals, cancer and aging; in Free radicals, aging and degenerative diseases (eds) JE Johnson Jr and J Miquel (New York: Alan R Liss, Inc.) 325-371
42. Ohkawa H, Ohishi M and Yagi 1970 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 351-358
43. Olney JW, Labruyere J and De Gubareff T 1980 Brain damage in mice from voluntary ingestion of glutamate and aspartate. Neurobehav. Toxicol. 2 125-129
44. Osterloh JD, Pond SM, Grady S and Becker CE 1986 Serum formate concentrations in methanol intoxication as a criterion for hemodialysis. Ann Intern Med. 104 2000-2003
45. Pan-Hou H, Suda Y, Ohe Y, Sumi M and Yoshioka M 1990 Effect of aspartame on N-methyl-D-aspartate-sensitive L-[3H]gluta-mate binding sites in rat brain synaptic membranes. Brain Res. 520 351-353
46. Pankow D and Jagielki S 1993 Effect of methanol on modifications of hepatic glutathione concentration on the metabolism of dichloromethane to carbon monoxide in rats. Hum. Exp. Toxicol. 12 227-231
47. Parthasarathy JN, Ramasundaram SK, Sundaramahalingam M and Rathinasamy SD 2006 Methanol induced oxidative stress in rat lymphoid organs. J. Occup. Health 48 20-27
48. Patsoukis N, Zervoudakis G, Panagopoulos NT, Georgiou CD, Angelatou F and Matsokis NA 2004 Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylene tetrazol-induced epileptic seizure. Neurosci. Lett. 357 83-86
49. Pecina R, Bonn G, Burtscher E and Bobber O 1984 High performance liquid chromatographic elution behavior of alcohols, aldehydes, ketones, organic acids and Carbohydrates on a strong catino-exchange stationary phase. J. Chromatogr. 287 245-258
50. Rajamani R, Muthuvel A, Senthilvelan M and Sheela Devi R 2006 Oxidative stress induced by Methotrexate alone and in the presence of methanol in discrete regions of the rodent brain, retina and optic nerve. Toxicol. Lett. 165 265-273
51. Rotruck JT, Pope AC, Ganther HE, Hafeman DG and Hoekstra WG 1973 Selenium biochemical role as a component of glutathione peroxidase. Science 179 588-590
52. Samuel S, Ramanathan K, Tamilselvan J and Panneersevam C 2005 Protein oxidative damage in arsenic induced rat brain: influence of DL-lipoic acid. Toxicol. Lett. 155 27-34
53. Sedlack J and Lindsay RH 1968 Estimation of total, protein bound and non-protein sulfhydryl groups in the tissue with Elman's reagent. Anal Biochem. 25 192-205
54. Shapiro RB 1988 Statement for the labor and human resources committee, US Senate (Washington, DC, Government Printing Office)
55. Skrzydlewska E, Witek A and Farbiszewski R 1998 The comparison of the antioxidant defense potential of brain to liver of rats after methanol ingestion. Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 120 289-294
56. Sohal RS, Mockett RJ and Orr WC 2002 Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Free Radical Biol. Med. 33 575-586
57. Stegink LD, Brummel MC, Filer LJ and Baker GL 1983 Blood methanol concentrations in one year old infants administered graded doses of aspartame. J. Nutr. 113 1600-1606
58. Tabor H and Wyngarden 1962 A method for determination of formiminoglutamic acid in urine. J. Clin. Invest. 37 824-828
59. Tephly TR and McMartin KE 1984 Methanol metabolism and toxicity; in Aspartame- physiology and biochemistry (eds) LD Stegink and LJ Filer Jr (New York: Marcel Dekker) pp 111-140
60. Tephly TR 1991 The toxicity of methanol. Life Sci. 48
61. 1031-1041 Yokogoshi H, Roberts CH, Caballero B and Wurtman RJ 1984 Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydroxyindoles. Am. J. Clin. Nutr. 40 1-7
62. Yu BP 1994 Cellular defenses against damage from reactive oxygen species. Physiol. Rev. 74 239-262