Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations

Pharmacogenomics Journal

Volumn 12, Issue 5, 2012, Pages 425-431

  Song, K ^a   Nelson, M R ^b   Aponte, J ^b   Manas, E S ^a   Bacanu, S A ^b   Yuan, X ^a   Kong, X ^a   Cardon, L ^a   Mooser, V E ^a   Whittaker, J C ^c   Waterworth, D M ^a  

^a GLAXOSMITHKLINE   (United States)

^b Hamner Institutes for Health Sciences   (United States)

^c Department of Genetics ^*  (United Kingdom)

Author keywords

enzyme activity; Lp PLA2; rare variant; re sequencing

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; PHOSPHOLIPASE A2 INHIBITOR;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; DNA SEQUENCE; ENZYME ACTIVITY; EUROPEAN UNION; EXON; FEMALE; GENE; GENE ACTIVITY; GENE FREQUENCY; GENE FUNCTION; GENETIC RISK; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; LOSS OF FUNCTION MUTATION; MALE; PLA2G7 GENE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RISK ASSESSMENT; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; AMINO ACID SUBSTITUTION; BIOMARKERS, PHARMACOLOGICAL; CORONARY DISEASE; ENZYME INHIBITORS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETICS, POPULATION; HOMOZYGOTE; HUMANS; MUTATION; PHOSPHOLIPASES A2; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA;

EID: 84866736410     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2011.20     Document Type: Article

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