Prognostic significance of elevated D-dimer for survival in patients with sarcoma

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 35, Issue 5, 2012, Pages 462-467

  Raj, Sean D ^a   Zhou, Xiao ^a,b   Bueso Ramos, Carlos E ^b   Ravi, Vinod ^b   Patel, Shreyaskumar ^b   Benjamin, Robert S ^b   Vadhan Raj, Saroj ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

D dimer; metastasis; prognosis; sarcoma; survival

Indexed keywords

D DIMER; DOXORUBICIN; IFOSFAMIDE;

ADOLESCENT; ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PROGNOSIS; CANCER RELAPSE; CANCER RISK; CANCER SURVIVAL; CLINICAL ARTICLE; CONFIDENCE INTERVAL; FEMALE; FOLLOW UP; HAZARD RATIO; HUMAN; INOPERABLE CANCER; KAPLAN MEIER METHOD; LOG RANK TEST; MALE; METASTASIS; MORTALITY; MULTIPLE CYCLE TREATMENT; PREDICTION; PROPORTIONAL HAZARDS MODEL; SOFT TISSUE SARCOMA; TREATMENT DURATION; TREATMENT RESPONSE; VENOUS THROMBOEMBOLISM;

ADOLESCENT; ADULT; AGED; BONE NEOPLASMS; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; PROTEIN MULTIMERIZATION; RISK FACTORS; SARCOMA; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84866733709     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/COC.0b013e31821d4529     Document Type: Article

References (30)

1. De Buyzere M, Philippé J, Duprez D, et al. Coagulation system activation and increase of D-dimer levels in peripheral arterial occlusive disease. Am J Hematol. 1993;43:91-94.
2. Sumney M, Whiteman K. D-dimer: Past, present, and future. CE Connection available at: http://www.nursingcenter.com. Accessed Oct. 10, 2010.
3. Loppi G, Franchini M, Targher G, et al. Help me, Doctor! My D-dimer is raised. Ann Int Med. 2008;40:594-605.
4. Sood SL. Cancer-associated thrombosis. Curr Opin Hematol. 2009;16:378-385.
5. de Moerloose P. D-dimer assays for the exclusion of venous thromboembolism: which test for which diagnostic strategy? Thromb Haemost. 2000;83:180-181.
6. Wells PS, Anderson DR, Rodger M, et al. Evaluation of D-Dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med. 2003;349:1227-1235.
7. van der Graaf F, van den Borne H, van der Kolk M, et al. Exclusion of deep venous thrombosis with D-dimer testing. Comparison of 13 D-dimer methods in 99 outpatients suspected of deep venous thrombosis using venography as reference standard. Thromb Haemost. 2000;83:191-198.
8. Meijer K, Schulman S. The absence of minor risk factors for recurrent venous thromboembolism: a systematic review of negative predictive values and negative likelihood ratios. J Thromb Haemost. 2009;7:1619-1628.
9. Shitrit D, Izbicki G, Shitrit AB, et al. Prognostic value of a new quantitative D-dimer test in critically ill patients 24 and 48 h following admission to the intensive care unit. Blood Coagul Fibrinolysis. 2004;15:15-19.
10. Nozawa T, Inoue H, Hirai T, et al. D-dimer level influences thromboembolic events in patients with atrial fibrillation. Int J Cardiol. 2006;109:59-65.
11. Mahe I, Drouet L, Simoneau G, et al. D-dimer can predict survival in patients with chronic atrial fibrillation. Blood Coagul Fibrino-lysis. 2004;15:413-417.
12. Beer H, Haeberli A, Vogt A, et al. Coagulation markers predict survival in cancer patients. Thromb Haemost. 2002;88: 745-749.
13. Shorr AF, Thomas SJ, Alkins SA, et al. D-dimer correlates with proinflammatory cytokine levels and outcomes in critically ill patients. Chest. 2002;121:1262-1268.
14. Shoji M, Hancock WW, Abe K, et al. Activation of coagulation and angiogenesis in cancer. Am J Pathol. 1998;152:399-411.
15. Antoniou D, Pavlakou G, Stathopoulos GP, et al. Predictive value of D-dimer plasma levels in response and progressive disease in patients with lung cancer. Lung Cancer. 2006;53:205-210.
16. Solomon KS. D-Dimer levels correlate strongly with lung carcinoma prognosis. Cancer. 2003;97:3044-3052.
17. Taguchi O, Gabazza EC, Yasui H, et al. Prognostic significance of plasma D-dimer levels in patients with lung cancer. Thorax. 1997;52:563-565.
18. Pavey SJ, Hawson GAT, Marsh NA. Impact of the fibrinolytic enzyme system on prognosis and survival associated with non-small cell lung carcinoma. Blood Coagul Fibrinolyis. 2001;12: 51-58.
19. Altiay G, Ciftci A, Demir M, et al. High plasma D-dimer level is associated with decreased survival in patients with lung cancer. J Clin Oncol. 2007;19:494-498.
20. Blackwell K, Haroon Z, Broadwater G, et al. Plasma D-dimer levels in operable breast cancer patients correlate with clinical stage and axillary lymph node status. J Clin Oncol. 2000;18:600-608.
21. Dirix LY, Salgado R, Weytjens R, et al. Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer. Br J Cancer. 2002;86: 389-395.
22. Kilic M, Yoldas O, Keskek M, et al. Prognostic value of plasma D-dimer levels in patients with colorectal cancer. The Association of Coloproctology of Great Britain and Ireland. Colorectal Dis. 2007;10:238-241.
23. Xu G, Zhang YL, Huan W. Relantionship between plasma D-dimer levels and clinicopathologic parameters in respectable colorectal cancer patients. World J Gastroenterol. 2004;10:922-923.
24. Oya M, Akiyama Y, Okuyama T, et al. High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer. Jpn J Clin Oncol. 2001;31:388-394.
25. Blackwell K, Hurwitz H, Lieberman G, et al. Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen level in patients with metastatic colorectal carcinoma. Cancer. 2004;101:77-82.
26. Knowlson L, Bacchu S, Paneesha S, et al. Elevated D-dimers are also a marker of underlying malignancy and increased mortality in the absence of venous thromboembolism. J Clin Pathol. 2010. Published on line July 29.
27. Ay C, Vormittag R, Dunkler D, et al. D-dimer and prothrombin fragment 1+2 predit venous thromboembolism in patients with cancer: results from the Vienna Cancer and Thrombosis study. J Clin Oncol. 2009;27:4124-4129.
28. Gaducci A, Baicchi U, Marrai R, et al. Pretreatment plasma levels of fibrinopeptide-A (FPD), D-dimer (DD), and von Willebrand factor (vWF) in patients with operable cervical cancer: influence of surgical-pathological stage, tumor size, histologic type, and lymph node status. Gynecol Oncol. 1993;49:354-358.
29. Patel SR, Vadhan-Raj S, Burgess MA, et al. Results of two consecutive trials of dose-intensive chemotherapy with Doxor-ubicin and Ifosfamide in patients with Sarcomas. Am J Clin Oncol. 1998;21:317-321.
30. Palareti G, Cosmi B, Legnani C, et al. D-Dimer testing to determine the duration of anticoagulation therapy. N Engl J Med. 2006;355:1780-1789.