Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6- dihydropyrimidin-2-yl)amide derivatives as PI3Kβ inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6381-6384

  Certal, Victor ^a   Halley, Frank ^a   Virone Oddos, Angela ^a   Thompson, Fabienne ^a   Filoche Rommé, Bruno ^a   El Ahmad, Youssef ^a   Carry, Jean Christophe ^a   Delorme, Cécile ^a   Karlsson, Andreas ^a   Abecassis, Pierre Yves ^a   Vincent, Loic ^a   Bonnevaux, Hélène ^a   Nicolas, Jean Paul ^a   Morales, Renaud ^a   Michot, Nadine ^a   Vade, Isabelle ^a   Louboutin, Audrey ^a   Perron, Sébastien ^a   Doerflinger, Gilles ^a   Tric, Bernadette ^a   Monget, Sylvie ^a   Lengauer, Christoph ^a   Schio, Laurent ^a   more..

^a SANOFI   (France)

Author keywords

Kinase inhibitor; pAkt; PI3K ; PTEN; Pyrimidone anilide

Indexed keywords

4 (MORPHOLIN 4 YL)(6 OXO 1,6 DIHYDROPYRIMIDIN 2 YL)AMIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE BETA; PHOSPHATIDYLINOSITOL 3 KINASE BETA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CANCER CELL CULTURE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PHARMACODYNAMICS; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANILIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; CRYSTALLOGRAPHY, X-RAY; FEMALE; GENE DELETION; HUMANS; MALE; MICE; MICE, SCID; MODELS, MOLECULAR; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN ISOFORMS; PTEN PHOSPHOHYDROLASE; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 84866732699     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.072     Document Type: Article

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