Phenelzine (monoamine oxidase inhibitor) increases production of nitric oxide and proinflammatory cytokines via the NF-κB pathway in lipopolysaccharide-activated microglia cells

Neurochemical Research

Volumn 37, Issue 10, 2012, Pages 2117-2124

  Chung, Hwan Suck ^a   Kim, Hyunseong ^a   Bae, Hyunsu ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Microglia; NF B; Nitric oxide; Phenelzine; Tumor necrosis factor a

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; NITRIC OXIDE; PHENELZINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; MICROGLIA; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ANIMALS; BASE SEQUENCE; CELL LINE, TRANSFORMED; CYTOKINES; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MONOAMINE OXIDASE INHIBITORS; NF-KAPPA B; NITRIC OXIDE; PHENELZINE; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84866728940     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0833-y     Document Type: Article

References (43)

1. Johnson MR, Lydiard RB, Ballenger JC (1995) Panic disorder. Pathophysiology and drug treatment. Drugs 49:328-344
2. Casacalenda N, Perry JC, Looper K (2002) Remission in major depressive disorder: a comparison of pharmacotherapy, psychotherapy, and control conditions. Am J Psychiatry 159:1354-1360
3. Michael-Titus AT, Bains S, Jeetle J, Whelpton R (2000) Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex-a possible mechanism of neuroprotection in major depression? Neuroscience 100:681-684
4. Parent MB, Master S, Kashlub S, Baker GB (2002) Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum. Biochem Pharmacol 63:57-64
5. Chiche F, Le Guillou M, Chetrite G, Lasnier F, Dugail I, Carpene C, Moldes M, Feve B (2009) Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes. Mol Pharmacol 75:1052-1061
6. Lee CS, Han ES, Lee WB (2003) Antioxidant effect of phenelzine on mpp+-induced cell viability loss in differentiated pc12 cells. Neurochem Res 28:1833-1841
7. Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A (2011) The role of microglia in the healthy brain. J Neurosci 31:16064-16069
8. Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease-a double-edged sword. Neuron 35:419-432
9. Ehde DM, Bombardier CH (2005) Depression in persons with multiple sclerosis. Phys Med Rehabil Clin N Am 16:437-448, ix
10. Marshall PS (1993) Allergy and depression: a neurochemical threshold model of the relation between the illnesses. Psychol Bull 113:23-43
11. Katon W, Sullivan MD (1990) Depression and chronic medical illness. J Clin Psychiatry 51Suppl:3-11 (discussion 12-14)
12. Schrott LM, Crnic LS (1996) Anxiety behavior, exploratory behavior, and activity in nzb x nzw f1 hybrid mice: role of genotype and autoimmune disease progression. Brain Behav Immun 10:260-274
13. Asnis GM, De La Garza R II (2006) Interferon-induced depression in chronic hepatitis c: a review of its prevalence, risk factors, biology, and treatment approaches. J Clin Gastroenterol 40:322-335
14. Tyring S, Gottlieb A, Papp K, Gordon K, Leonardi C, Wang A, Lalla D, Woolley M, Jahreis A, Zitnik R et al (2006) Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase iii trial. Lancet 367:29-35
15. Sluzewska A, Rybakowski J, Bosmans E, Sobieska M, Berghmans R, Maes M, Wiktorowicz K (1996) Indicators of immune activation in major depression. Psychiatry Res 64:161-167
16. Gantt KR, Goldman TL, McCormick ML, Miller MA, Jeronimo SM, Nascimento ET, Britigan BE, Wilson ME (2001) Oxidative responses of human and murine macrophages during phagocytosis of leishmania chagasi. J Immunol 167:893-901
17. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL et al (2000) Inflammation and alzheimer's disease. Neurobiol Aging 21:383-421
18. McGeer PL, McGeer EG (2004) Inflammation and neurodegeneration in parkinson's disease. Parkinsonism Relat Disord 10(Suppl 1): S3-S7
19. Danton GH, Dietrich WD (2003) Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 62:127-136
20. Chao CC, Hu S, Peterson PK (1995) Glia, cytokines, and neurotoxicity. Crit Rev Neurobiol 9:189-205
21. Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A (1987) Anti-cachectin/tnf monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330:662-664
22. Baker SJ, Reddy EP (1998) Modulation of life and death by the tnf receptor superfamily. Oncogene 17:3261-3270
23. Vilcek J, Lee TH (1991) Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. J Biol Chem 266:7313-7316
24. Sweet MJ, Hume DA (1996) Endotoxin signal transduction in macrophages. J Leukoc Biol 60:8-26
25. Kuprash DV, Udalova IA, Turetskaya RL, Rice NR, Nedospasov SA (1995) Conserved kappa b element located downstream of the tumor necrosis factor alpha gene: distinct nf-kappa b binding pattern and enhancer activity in lps activated murine macrophages. Oncogene 11:97-106
26. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27:229-237
27. Chung HS, Lee JH, Kim H, Lee HJ, Kim SH, Kwon HK, Im SH, Bae H (2010) Foxp3 is a novel repressor of microglia activation. Glia 58:1247-1256
28. Saura J, Tusell JM, Serratosa J (2003) High-yield isolation of murine microglia by mild trypsinization. Glia 44:183-189
29. Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256:225-228
30. Chung HS, Kang M, Cho C, Parvez S, Park CH, Kim D, Oh J, Kim H, Shin M, Hong M et al (2007) Inhibition of nitric oxide and tumor necrosis factor-alpha by moutan cortex in activated mouse peritoneal macrophages. Biol Pharm Bull 30:912-916
31. Stoll G, Jander S (1999) The role of microglia and macrophages in the pathophysiology of the cns. Prog Neurobiol 58:233-247
32. Kreutzberg GW (1996) Microglia: a sensor for pathological events in the cns. Trends Neurosci 19:312-318
33. Vila M, Jackson-Lewis V, Guegan C, Wu DC, Teismann P, Choi DK, Tieu K, Przedborski S (2001) The role of glial cells in parkinson's disease. Curr Opin Neurol 14:483-489
34. Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, O'Callaghan JP (2006) Deficiency of tnf receptors suppresses microglial activation and alters the susceptibility of brain regions to mptp-induced neurotoxicity: role of tnf-alpha. FASEB J 20: 670-682
35. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA (2001) Possible new role for nf-kappab in the resolution of inflammation. Nat Med 7:1291-1297
36. Makarov SS (2001) Nf-kappa b in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res 3:200-206
37. Boje KM, Arora PK (1992) Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587:250-256
38. Majumder S, Zhou LZ, Chaturvedi P, Babcock G, Aras S, Ransohoff RM (1998) P48/stat-1alpha-containing complexes play a predominant role in induction of ifn-gamma-inducible protein, 10 kDa (ip-10) by ifn-gamma alone or in synergy with tnf-alpha. J Immunol 161:4736-4744
39. Piao HZ, Choi IY, Park JS, Kim HS, Cheong JH, Son KH, Jeon SJ, Ko KH, Kim WK (2008) Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa b activity. Int Immunopharmacol 12:1658-1662
40. Henry JA, Antao CA (1992) Suicide and fatal antidepressant poisoning. Eur J Med 1:343-348
41. Ciocatto E, Fagiano G, Bava GL (1972) Clinical features and treatment of overdosage of monoamine oxidase inhibitors and their interaction with other psychotropic drugs. Resuscitation 1:69-72
42. Linden CH, Rumack BH, Strehlke C (1984) Monoamine oxidase inhibitor overdose. Ann Emerg Med 13:1137-1144
43. Waring WS, Wallace WA (2007) Acute myocarditis after massive phenelzine overdose. Eur J Clin Pharmacol 63:1007-1009