Local Delivery of Nimodipine by Prolonged-Release Microparticles-Feasibility, Effectiveness and Dose-Finding in Experimental Subarachnoid Hemorrhage

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Hänggi, Daniel ^a   Perrin, Jason ^a   Eicker, Sven ^a   Beseoglu, Kerim ^a   Etminan, Nima ^a   Kamp, Marcel Alexander ^a   Heiroth, Hi Jae ^a   Bege, Nadia ^b   Macht, Stephan ^a   Frauenknecht, Katrin ^c   Sommer, Clemens ^c   Kissel, Thomas ^b   Steiger, Hans Jakob ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; NIMODIPINE; POLYGLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; BRAIN INJURY; BRAIN VASOSPASM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIGITAL SUBTRACTION ANGIOGRAPHY; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MEGADOSE; DRUG RELEASE; DRUG SAFETY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PARTICLE SIZE; PROTEIN EXPRESSION; RAT; SUBARACHNOID HEMORRHAGE;

ANGIOGRAPHY, DIGITAL SUBTRACTION; ANIMALS; BRAIN; CALCIUM-BINDING PROTEINS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENOUS; LACTIC ACID; MALE; MICROFILAMENT PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NIMODIPINE; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; SUBARACHNOID HEMORRHAGE; VASODILATOR AGENTS; VASOSPASM, INTRACRANIAL;

ANIMALIA; RATTUS NORVEGICUS;

EID: 84866720510     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042597     Document Type: Article

References (31)

1. Lovelock CE, Rinkel GJ, Rothwell PM, (2010) Time trends in outcome of subarachnoid hemorrhage: Population-based study and systematic review. Neurology 74: 1494-1501.
2. Suarez JI, Tarr RW, Selman WR, (2006) Aneurysmal subarachnoid hemorrhage. N Engl J Med 354: 387-396.
3. Hop JW, Rinkel GJ, Algra A, van Gijn J, (1997) Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review. Stroke 28: 660-664.
4. Barth M, Capelle HH, Weidauer S, Weiss C, Munch E, et al. (2007) Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. Stroke 38: 330-336.
5. Kasuya H, Onda H, Sasahara A, Takeshita M, Hori T, (2005) Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage. Neurosurgery 56: 895-902; discussion 895-902.
6. Bederson JB, Levy AL, Ding WH, Kahn R, DiPerna CA, et al. (1998) Acute vasoconstriction after subarachnoid hemorrhage. Neurosurgery 42: 352-360; discussion 360-352.
7. Grasso G, (2004) An overview of new pharmacological treatments for cerebrovascular dysfunction after experimental subarachnoid hemorrhage. Brain Res Brain Res Rev 44: 49-63.
8. Megyesi JF, Vollrath B, Cook DA, Findlay JM, (2000) In vivo animal models of cerebral vasospasm: a review. Neurosurgery 46: 448-460; discussion 460-441.
9. Lee SH, Heng D, Ng WK, Chan HK, Tan RB, (2011) Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy. Int J Pharm 403: 192-200.
10. Li X, Anton N, Arpagaus C, Belleteix F, Vandamme TF, (2010) Nanoparticles by spray drying using innovative new technology: the Buchi nano spray dryer B-90. J Control Release 147: 304-310.
11. Turowski B, Hanggi D, Beck A, Aurich V, Steiger HJ, et al. (2007) New angiographic measurement tool for analysis of small cerebral vessels: application to a subarachnoid haemorrhage model in the rat. Neuroradiology 49: 129-137.
12. Paxinos G, Watson C (2007) The rat brain stereotaxic coordinates. Elsevier, Academic Press.
13. Tanay E, Mundel P, Sommer C, (2006) Short-term ischemia usually used for ischemic preconditioning causes loss of dendritic integrity after long-term survival in the gerbil hippocampus. Brain Res 1112: 222-226.
14. Prunell GF, Mathiesen T, Svendgaard NA, (2004) Experimental subarachnoid hemorrhage: cerebral blood flow and brain metabolism during the acute phase in three different models in the rat. Neurosurgery 54: 426-436; discussion 436-427.
15. Delgado TJ, Brismar J, Svendgaard NA, (1985) Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries. Stroke 16: 595-602.
16. Verlooy J, Van Reempts J, Haseldonckx M, Borgers M, Selosse P, (1992) The course of vasospasm following subarachnoid haemorrhage in rats. A vertebrobasilar angiographic study. Acta Neurochir (Wien) 117: 48-52.
17. Vatter H, Weidauer S, Konczalla J, Dettmann E, Zimmermann M, et al. (2006) Time course in the development of cerebral vasospasm after experimental subarachnoid hemorrhage: clinical and neuroradiological assessment of the rat double hemorrhage model. Neurosurgery 58: 1190-1197; discussion 1190-1197.
18. Hanggi D, Eicker S, Beseoglu K, Rapp M, Perrin J, et al. (2009) Dose-related efficacy of a continuous intracisternal nimodipine treatment on cerebral vasospasm in the rat double subarachnoid hemorrhage model. Neurosurgery 64: 1155-1159; discussion 1159-1161.
19. Aladag MA, Turkoz Y, Sahna E, Parlakpinar H, Gul M, (2003) The attenuation of vasospasm by using a sod mimetic after experimental subarachnoidal haemorrhage in rats. Acta Neurochir (Wien) 145: 673-677.
20. Satoh M, Parent AD, Zhang JH, (2002) Inhibitory effect with antisense mitogen-activated protein kinase oligodeoxynucleotide against cerebral vasospasm in rats. Stroke 33: 775-781.
21. Voldby B, Petersen OF, Buhl M, Jakobsen P, Ostergaard R, (1984) Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine). Acta Neurochir (Wien) 70: 243-254.
22. Gioia AE, White RP, Bakhtian B, Robertson JT, (1985) Evaluation of the efficacy of intrathecal nimodipine in canine models of chronic cerebral vasospasm. J Neurosurg 62: 721-728.
23. Zabramski JM, Spetzler RF, Bonstelle C, (1986) Chronic cerebral vasospasm: effect of volume and timing of hemorrhage in a canine model. Neurosurgery 18: 1-6.
24. Lewis PJ, Weir BK, Nosko MG, Tanabe T, Grace MG, (1988) Intrathecal nimodipine therapy in a primate model of chronic cerebral vasospasm. Neurosurgery 22: 492-500.
25. Marbacher S, Neuschmelting V, Graupner T, Jakob SM, Fandino J, (2008) Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo. Intensive Care Med 34: 932-938.
26. Auer LM, Ito Z, Suzuki A, Ohta H, (1982) Prevention of symptomatic vasospasm by topically applied nimodipine. Acta Neurochir (Wien) 63: 297-302.
27. Hanggi D, Beseoglu K, Turowski B, Steiger HJ, (2008) Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy. Clin Neurol Neurosurg 110: 784-790.
28. Frauenknecht K, Bargiotas P, Bauer H, von Landenberg P, Schwaninger M, et al. (2010) Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody. J Neuroimmunol 227: 1-9.
29. Boullin DJ, Aitken V, du Boulay GH, Tagari P, (1981) The calibre of cerebral arteries of the rat studied by carotid angiography: a model system for studying the aetiology of human cerebral arterial constriction after aneurysmal rupture. Neuroradiology 21: 245-252.
30. Longo M, Blandino A, Ascenti G, Ricciardi GK, Granata F, et al. (2002) Cerebral angiography in the rat with mammographic equipment: a simple, cost-effective method for assessing vasospasm in experimental subarachnoid haemorrhage. Neuroradiology 44: 689-694.
31. Ono S, Date I, Nakajima M, Onoda K, Ogihara K, et al. (1997) Three-dimensional analysis of vasospastic major cerebral arteries in rats with the corrosion cast technique. Stroke 28: 1631-1637; discussion 1638.