Short-term ischemia usually used for ischemic preconditioning causes loss of dendritic integrity after long-term survival in the gerbil hippocampus

Brain Research

Volumn 1112, Issue 1, 2006, Pages 222-226

  Tanay, Emre ^a   Mundel, Peter ^b   Sommer, Clemens ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Gerbil; Immunohistochemistry; Ischemic preconditioning; MAP1B; MAP2; Synaptopodin

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 5; SYNAPTOPODIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; DENDRITE; GERBIL; HIPPOCAMPUS; IMMUNOREACTIVITY; ISCHEMIC PRECONDITIONING; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL TIME;

ANIMALS; CELL COUNT; DENDRITES; GERBILLINAE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; ISCHEMIC ATTACK, TRANSIENT; ISCHEMIC PRECONDITIONING; MALE; MICROFILAMENT PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NEUROLOGIC EXAMINATION;

ANIMALIA; GERBILLINAE;

EID: 33748414459     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.07.004     Document Type: Article

References (18)

1. Abe H., and Nowak Jr. T.S. Induced hippocampal neuron protection in an optimized gerbil ischemia model: insult thresholds for tolerance induction and altered gene expression defined by ischemic depolarization. J. Cereb. Blood Flow Metab. 24 (2003) 84-97
2. Corbett D., and Crooks P. Ischemic preconditioning: a long term survival study using behavioural and histological endpoints. Brain Res. 760 (1997) 129-136
3. Deller T., Merten T., Roth S.U., Mundel P., and Frotscher M. Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. J. Comp. Neurol. 418 (2000) 164-181
4. Deller T., Korte M., Chabnis S., Drakew A., Schwegler H., Stefani G.G., Zuniga A., Schwarz K., Bonhoeffer T., Zeller R., Frotscher M., and Mundel P. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 10494-10499
5. Dirnagl U., Simon R.P., and Hallenbeck J.M. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 26 (2003) 248-254
6. Dooley P., and Corbett D. Competing processes of cell death and recovery of function following ischemic preconditioning. Brain Res. 794 (1998) 119-126
7. Dowden J., and Corbett D. Ischemic preconditioning in 18- to 20-month-old gerbils. long-term survival with functional outcome measures. Stroke 30 (1999) 1240-1246
8. Gonzalez-Billaut C., Jimenez-Mateos E.M., Caceres A., Diaz-Nido J., Wandosell F., and Avila J. Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system. J. Neurobiol. 58 (2004) 48-59
9. Kirino T., Tsujita Y., and Tamura A. Induced tolerance to ischemia in gerbil hippocampal neurons. J. Cereb. Blood Flow Metab. 11 (1991) 299-307
10. Kitagawa K., Matsumoto M., Niinobe M., Mikoshiba K., Hata R., Ueda H., Handa N., Fukunaga R., Isaka Y., Kimura K., and Kamada T. Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage: immunohistochemical investigation of dendritic damage. Neuroscience 31 (1989) 401-411
11. Matesic D.F., and Lin R.C.S. Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain. J. Neurochem. 63 (1994) 1012-1020
12. Mundel P., Heid H.W., Mundel T.M., Krüger M., Reiser J., and Kriz W. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J. Cell Biol. 139 (1997) 193-204
13. Schomacher M., Müller H.D., and Sommer C. Short-term ischemia usually used for ischemic preconditioning downregulates central cannabinoid (CB1) receptors in the gerbil hippocampus. Acta Neuropathol. (Berl.) 111 (2006) 8-14
14. Sommer C., and Kiessling M. Ischemia and ischemia tolerance induction differentially regulate protein expression of GluR1, GluR2 and AMPA receptor binding protein (ABP) in the gerbil hippocampus: GluR2 (GluR-B) reduction does not predict neuronal death. Stroke 33 (2002) 1093-1100
15. Sommer C., Gass P., and Kiessling M. Selective c-JUN expression in CA1 neurons of the gerbil hippocampus during and after acquisition of an ischemia-tolerant state. Brain Pathol. 5 (1995) 135-144
16. Sommer C., Roth S.U., Kuhn R., and Kiessling M. Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance induction in the gerbil hippocampus. Brain Res. 872 (2000) 172-180
17. A receptors. Acta Neuropathol. (Berl.) 105 (2003) 197-202
18. Tucker R.P. The roles of microtubule-associated proteins in brain morphogenesis: a review. Brain Res. Brain Res. Rev. 15 (1990) 101-120