Resistin-like molecule-β is induced following bronchoconstriction of asthmatic airways

Respirology

Volumn 17, Issue 7, 2012, Pages 1094-1100

  Grainge, Christopher ^a,b   Dulay, Valdeep ^a   Ward, Jonathan ^a   Sammut, David ^a   Davies, Elizabeth ^a   Green, Benjamin ^a   Lau, Laurie ^a   Cottey, Laura ^a   Haitchi, Hans Michael ^a   Davies, Donna E ^a   Howarth, Peter H ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

allergen; asthma; methacholine; remodelling; resistin like molecule

Indexed keywords

ALLERGEN; MESSENGER RNA; METHACHOLINE; RESISTIN; RESISTIN LIKE MOLECULE BETA; SALBUTAMOL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ASTHMA; BRONCHOSPASM; BRONCHUS BIOPSY; DISEASE MARKER; DISEASE SEVERITY; FIBEROPTIC BRONCHOSCOPY; FORCED EXPIRATORY VOLUME; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; AIRWAY REMODELING; ALLERGENS; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTION; BRONCHOSCOPY; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; METHACHOLINE CHLORIDE; MIDDLE AGED; YOUNG ADULT;

EID: 84866647799     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2012.02215.x     Document Type: Article

References (19)

1. Grainge CL, Lau LC, Ward JA, et al,. Effect of bronchoconstriction on airway remodeling in asthma. N. Engl. J. Med. 2011; 364: 2006-15.
2. Mishra A, Wang M, Schlotman J, et al,. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007; 293: L305-13.
3. Steppan CM, Brown EJ, Wright CM, et al,. A family of tissue-specific resistin-like molecules. Proc. Natl Acad. Sci. U.S.A. 2001; 98: 502-6.
4. Steppan CM, Bailey ST, Bhat S, et al,. The hormone resistin links obesity to diabetes. Nature 2001; 409 (6818): 307-12.
5. Youn BS, Yu KY, Park HJ, et al,. Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 2004; 89 (1): 150-6.
6. Nair MG, Guild KJ, Artis D,. Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J. Immunol. 2006; 177: 1393-9.
7. Angelini DJ, Su Q, Yamaji-Kegan K, et al,. Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension. Am. J. Respir. Cell Mol. Biol. 2009; 41: 553-61.
8. Yamaji-Kegan K, Su Q, Angelini DJ, et al,. Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006; 291: L1159-68.
9. Liu T, Dhanasekaran SM, Jin H, et al,. FIZZ1 stimulation of myofibroblast differentiation. Am. J. Pathol. 2004; 164: 1315-26.
10. Zimmermann N, Mishra A, King NE, et al,. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J. Immunol. 2004; 172 (3): 1815-24.
11. Stütz AM, Pickart LA, Trifilieff A, et al,. The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism. J. Immunol. 2003; 170: 1789-96.
12. Fang C, Meng Q, Wu H, et al,. Resistin-like molecule- (RELM-) is a human airways remodelling mediator. Eur. Respir. J. 2012; 39: 458-66.
13. Grainge C, Howarth PH,. Repeated high-dose inhalation allergen challenge in asthma. Clin. Respir. J. 2011; 5: 150-5.
14. British Thoracic Society Bronchoscopy Guidelines Committee a Subcommittee of Standards of Care Committee of British Thoracic Society. British Thoracic Society guidelines on diagnostic flexible bronchoscopy. Thorax 2001; 56 (Suppl. 1): i1-21.
15. Annes JP, Munger JS, Rifkin DB,. Making sense of latent TGFbeta activation. J. Cell Sci. 2003; 116 (Pt 2): 217-24.
16. Pesce JT, Ramalingam TR, Wilson MS, et al,. Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. Plos Pathog. 2009; 5: e1000393.
17. Niimi A, Matsumoto H, Amitani R, et al,. Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. Am. J. Respir. Crit. Care Med. 2000; 162 (4 Pt 1): 1518-23.
18. de Blic J, Tillie-Leblond I, Emond S, et al,. High-resolution computed tomography scan and airway remodeling in children with severe asthma. J. Allergy Clin. Immunol. 2005; 116: 750-4.
19. Bourdin A, Neveu D, Vachier I, et al,. Specificity of basement membrane thickening in severe asthma. J. Allergy Clin. Immunol. 2007; 119: 1367-74.