Strategies for personalized medicine-based research and implementation in the clinical workflow

Clinical Pharmacology and Therapeutics

Volumn 92, Issue 4, 2012, Pages 443-445

  Lieb, W ^a   Volzke H ^a   Pulley, J M ^b   Roden, D M ^b   Kroemer, H K ^a  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL RESEARCH; COHORT ANALYSIS; ELECTRONIC MEDICAL RECORD; HUMAN; KNOWLEDGE; PERSONALIZED MEDICINE; PHENOTYPE; PRIORITY JOURNAL; WORKFLOW;

BIOMEDICAL RESEARCH; HUMANS; INDIVIDUALIZED MEDICINE; PHARMACOGENETICS; TRANSLATIONAL MEDICAL RESEARCH; WORKFLOW;

EID: 84866594005     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.119     Document Type: Article

References (5)

1. Roden, D.M., Wilke, R.A., Kroemer, H.K. & Stein, C.M. Pharmacogenomics: the genetics of variable drug responses. Circulation 123, 1661-1670 (2011).
2. Roden, D.M. et al. Development of a large-scale de-identifed DNA biobank to enable personalized medicine. Clin. Pharmacol. Ther. 84, 362-369 (2008).
3. Suhre, K. et al. A genome-wide association study of metabolic traits in human urine. Nat. Genet. 43, 565-569 (2011).
4. Pulley, J.M. et al. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDIct project. Clin. Pharmacol. Ther. 92, 87-95 (2012).
5. Link, E. et al.; SEARcH collaborative Group. SLcO1B1 variants and statin-induced myopathy\a genomewide study. N. Engl. J. Med. 359, 789-799 (2008).