Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training: Role of adenosine and prostacyclin

Journal of Hypertension

Volumn 30, Issue 10, 2012, Pages 2007-2014

  Hellsten, Ylva ^a   Jensen, Lasse ^a   Thaning, Pia ^b   Nyberg, Michael ^a   Mortensen, Stefan ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

Author keywords

blood flow; interstitium; microdialysis; skeletal muscle; vasodilator

Indexed keywords

ADENOSINE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PROSTACYCLIN;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; ESSENTIAL HYPERTENSION; EXERCISE; FEMALE; FEMORAL VEIN; HUMAN; HUMAN TISSUE; INTERSTITIAL FLUID; LEG BLOOD FLOW; MALE; MICRODIALYSIS; MUSCLE BIOPSY; PRIORITY JOURNAL; VASODILATATION; VASTUS LATERALIS MUSCLE; VENOUS BLOOD;

EID: 84866566075     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328356dd57     Document Type: Article

References (23)

1. Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 1993; 87:1468-1474.
2. Taddei S, Virdis A, Mattei P, Ghiadoni L, Fasolo CB, Sudano I, et al. Hypertension causes premature aging of endothelial function in humans. Hypertension 1997; 29:736-743.
3. Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation 1999; 100:1194-1202.
4. Taddei S, Virdis A, Ghiadoni L, Magagna A, Pasini AF, Garbin U, et al. Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients. J Hypertens 2001; 19:1379-1386.
5. Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol 2009; 157:527-536.
6. Hansen AH, Nyberg M, Bangsbo J, Saltin B, Hellsten Y. Exercise training alters the balance between vasoactive compounds in skeletal muscle of individuals with essential hypertension. Hypertension 2011; 58:943-949.
7. Ray CJ, Abbas MR, Coney AM, Marshall JM. Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilation: in vivo and in vitro studies. J Physiol 2002; 544:195-209.
8. Rådegran G, Calbet AL. Role of adenosine in exercise-induced human skeletal muscle vasodilation. Acta Physiol Scand 2001; 171:177-185.
9. Martin EA, Nicholson WT, Eisenach JH, Charkoudian N, Joyner MJ. Bimodal distribution of vasodilator responsiveness to adenosine due to difference in nitric oxide contribution: implications for exercise hyper-emia. J Appl Physiol 2006; 101:492-499.
10. Mortensen S, Nyberg M, Thaning P, Saltin B, Hellsten Y. Adenosine contributes to blood flow regulation in the exercising human leg by increasing nitric oxide and prostaglandin formation. Hypertension 2009; 53:993-999.
11. Smits P, Williams SB, Lipson DE, Bannit P, Rongen GA, Creager MA. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. Circulation 1995; 92:2135-2141.
12. Wihlborg AK, Malmsjo M, Eyjolfsson A, Gustafsson R, Jacobson K, Erlinge D. Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor. Br J Pharmacol 2003; 138:1451-1458.
13. Hellsten Y, Maclean D, Rådegran G, Saltin B, Bangsbo J. Adenosine concentrations in the interstitium of resting and contracting human skeletal muscle. Circulation 1998; 98:6-8.
14. Nyberg M, Mortensen SP, Thaning P, Saltin B, Hellsten Y. Interstitial and plasma adenosine stimulate nitric oxide and prostacyclin formation in human skeletal muscle. Hypertension 2010; 56:1102-1108.
15. Grundy SM, Pasternack R, Greenland P, Smith S, Fuster V. Assessment of cardiovascular risk by use of multiple risk factor assessment equations. Circulation 1999; 100:1482-11482.
16. Nyberg M, Jensen LG, Thaning P, Hellsten Y, Mortensen SP. Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high-intensity aerobic training. J Physiol 2012; 590:1481-1494.
17. Andersen P, Saltin B. Maximal perfusion of skeletal muscle in man. J Physiol 1985; 366:233-249.
18. Tullson PC, Whitlock DM, Terjung RL. Adenine nucleotide degradation in slow-twitch red muscle. Am J Physiol Cell Physiol 1990; 258:C258-C265.
19. Tare M, Parkington HC, Coleman HA. EDHF, NO and a prostanoid: hyperpolarization-dependent and independent relaxation in guinea-pig arteries. Br J Pharmacol 2000; 130:605-618.
20. Mortensen SP, Gonzalez-Alonso J, Damsgaard R, Saltin B, Hellsten Y. Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg. J Physiol 2007; 581:853-861.
21. Heinonen I, Saltin B, Kemppainen J, Sipilä HT, Oikonen V, Nuutila P, et al. Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition. Am J Physiol Heart Circ Physiol 2011; 300:H1510-H1517.
22. Hellsten Y, Frandsen U. Adenosine formation in contracting primary rat skeletal muscle cells and endothelial cells in culture. J Physiol 1997; 504:695-704.
23. Martin EA, Nicholson WT, Curry TB, Eisenach JH, CharkoudianN, Joyner MJ. Adenosine transporter antagonism in humans augments vasodilator responsiveness to adenosine, but not exercise, in both adenosine res-ponders and nonresponders. J Physiol 2007; 579:237-245.