Impurity profiling of trandolapril under stress testing: Structure elucidation of by-products and development of degradation pathway

International Journal of Pharmaceutics

Volumn 438, Issue 1-2, 2012, Pages 61-70

  Dendeni, M ^a,b,c   Cimetiere, N ^b,c   Amrane, A ^b,c   Hamida, N Ben ^a  

^a FACULTÉ DES SCIENCES DE TUNIS   (Tunisia)

^b UNIV RENNES   (France)

^c UNIVERSITÉ EUROPÉENNE DE BRETAGNE   (France)

Author keywords

Degradation pathway; Degradation products; ICH guideline (Q1A R2); Method development; Trandolapril; UPLC MS MS

Indexed keywords

TRANDOLAPRIL;

ARTICLE; DEGRADATION KINETICS; DIODE; DRUG DEGRADATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG IMPURITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIMIT OF QUANTITATION; PHARMACOLOGIC STRESS TESTING; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; DRUG STABILITY; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INDOLES; KINETICS; TANDEM MASS SPECTROMETRY;

EID: 84866562239     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.08.048     Document Type: Article

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