Heterozygosity for Fibrinogen Results in Efficient Resolution of Kidney Ischemia Reperfusion Injury

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Ajay, Amrendra Kumar ^a   Saikumar, Janani ^a   Bijol, Vanesa ^a   Vaidya, Vishal S ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; FIBRINOGEN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CYTOPLASM; GENE EXPRESSION PROFILING; HETEROZYGOSITY; IMMUNOCOMPETENT CELL; IN SITU HYBRIDIZATION; KIDNEY DYSFUNCTION; KIDNEY ISCHEMIA; KIDNEY NECROSIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; URINARY EXCRETION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; FIBRINOGEN; FLUORESCENT ANTIBODY TECHNIQUE; HETEROZYGOTE; IN SITU HYBRIDIZATION; KIDNEY DISEASES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY;

MUS;

EID: 84866554081     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045628     Document Type: Article

References (30)

1. Fuller GM, Zhang Z, (2001) Transcriptional control mechanism of fibrinogen gene expression. Ann N Y Acad Sci 936: 469-479.
2. Doolittle RF, (1984) Fibrinogen and fibrin. Annu Rev Biochem 53: 195-229.
3. Iacoviello L, Vischetti M, Zito F, Benedetta Donati M, (2001) Genes encoding fibrinogen and cardiovascular risk. Hypertension 38: 1199-1203.
4. Behague I, Poirier O, Nicaud V, Evans A, Arveiler D, et al. (1996) Beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. The ECTIM Study. Etude Cas-Temoins sur l'Infarctus du Myocarde. Circulation 93: 440-449.
5. Scarabin PY, Bara L, Ricard S, Poirier O, Cambou JP, et al. (1993) Genetic variation at the beta-fibrinogen locus in relation to plasma fibrinogen concentrations and risk of myocardial infarction. The ECTIM Study. Arterioscler Thromb 13: 886-891.
6. Reinhart WH, (2003) Fibrinogen-marker or mediator of vascular disease? Vasc Med 8: 211-216.
7. Peyvandi F, Haertel S, Knaub S, Mannucci PM, (2006) Incidence of bleeding symptoms in 100 patients with inherited afibrinogenemia or hypofibrinogenemia. J Thromb Haemost 4: 1634-1637.
8. Degen JL, Drew AF, Palumbo JS, Kombrinck KW, Bezerra JA, et al. (2001) Genetic manipulation of fibrinogen and fibrinolysis in mice. Ann N Y Acad Sci 936: 276-290.
9. Suh TT, Holmback K, Jensen NJ, Daugherty CC, Small K, et al. (1995) Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev 9: 2020-2033.
10. Iwaki T, Sandoval-Cooper MJ, Brechmann M, Ploplis VA, Castellino FJ, (2006) A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Blood 107: 3883-3891.
11. Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, et al. (2010) Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen. Cancer Res 70: 2634-2643.
12. Drew AF, Tucker HL, Liu H, Witte DP, Degen JL, et al. (2001) Crescentic glomerulonephritis is diminished in fibrinogen-deficient mice. Am J Physiol Renal Physiol 281: F1157-1163.
13. Vidal B, Serrano AL, Tjwa M, Suelves M, Ardite E, et al. (2008) Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. Genes Dev 22: 1747-1752.
14. Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ, (2006) Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice. J Pathol 210: 325-333.
15. Sorensen I, Susnik N, Inhester T, Degen JL, Melk A, et al. (2011) Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis. Kidney Int 80: 1035-1044.
16. Wilberding JA, Ploplis VA, McLennan L, Liang Z, Cornelissen I, et al. (2001) Development of pulmonary fibrosis in fibrinogen-deficient mice. Ann N Y Acad Sci 936: 542-548.
17. Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, et al. (2004) Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci U S A 101: 6698-6703.
18. Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, et al. (2005) The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med 11: 298-304.
19. Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, et al. (2006) Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol 169: 566-583.
20. Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, et al. (2007) Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest 117: 3224-3235.
21. Krishnamoorthy A, Ajay AK, Hoffmann D, Kim TM, Ramirez V, et al. (2011) Fibrinogen {beta}-derived B{beta}15-42 peptide protects against kidney ischemia/reperfusion injury. Blood 118: 1934-1942.
22. Krishnamoorthy A, Clement ME, O'Leary E, Bonventre JV, Vaidya VS, (2010) TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity. Toxicological sciences: an official journal of the Society of Toxicology 118: 298-306.
23. Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, et al. (2007) The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med 204: 571-582.
24. Sorensen I, Rong S, Susnik N, Gueler F, Shushakova N, et al. (2011) Bbeta(15-42) attenuates the effect of ischemia-reperfusion injury in renal transplantation. J Am Soc Nephrol 22: 1887-1896.
25. Altieri DC, Duperray A, Plescia J, Thornton GB, Languino LR, (1995) Structural recognition of a novel fibrinogen gamma chain sequence (117-133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interaction. J Biol Chem 270: 696-699.
26. Languino LR, Plescia J, Duperray A, Brian AA, Plow EF, et al. (1993) Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell 73: 1423-1434.
27. Languino LR, Duperray A, Joganic KJ, Fornaro M, Thornton GB, et al. (1995) Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition. Proc Natl Acad Sci U S A 92: 1505-1509.
28. Kelly KJ, Williams WW Jr, Colvin RB, Meehan SM, Springer TA, et al. (1996) Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest 97: 1056-1063.
29. Jeong HJ, Lee HH, Kim YS, Kim SI, Moon JI, et al. (1998) Expression of ICAM-1 and VCAM-1 in renal allograft rejection. Transplant Proc 30: 2953-2954.
30. Bonventre J, Yang L, (2011) Cellular pathophysiology of ischemic acute kidney injury. The Journal of clinical investigation 121: 4210-4231.