Vascular-targeted nanotherapy for obesity: Unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery

Journal of Controlled Release

Volumn 163, Issue 2, 2012, Pages 101-110

  Hossen, Md Nazir ^a   Kajimoto, Kazuaki ^a   Akita, Hidetaka ^a   Hyodo, Mamoru ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Active targeting; Anti angiogenesis; Obesity; Passive targeting; Vascular targeted nanoparticle

Indexed keywords

ACTIVE TARGETING; ADIPOSE TISSUE; ANTI-ANGIOGENESIS; BODY WEIGHT; CRITICAL FACTORS; DESIGN AND DEVELOPMENT; DIET-INDUCED OBESITY; ENDOSOMES; ENHANCED PERMEABILITY AND RETENTION EFFECT; IN-VITRO; IN-VIVO; NANOSCALED; OBESITY; PASSIVE TARGETING; PEGYLATION; PEPTIDE LIGAND; RETICULOENDOTHELIAL SYSTEMS; SYSTEMIC ADMINISTRATION; TARGETED DELIVERY; TUMOR TARGETING;

CYTOLOGY; DRUG DELIVERY; ENDOTHELIAL CELLS; LIGANDS; MAMMALS; NANOPARTICLES; PEPTIDES; TISSUE;

NUTRITION;

ANTIOBESITY AGENT; NANOPARTICLE; PROAPOPTOTIC PEPTIDE; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC THERAPY; ARTICLE; DRUG DELIVERY SYSTEM; DRUG MECHANISM; ENDOTHELIUM CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OBESITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM;

ADIPOSE TISSUE; ANIMALS; AZOLES; CHOLESTEROL; DIET, HIGH-FAT; DRUG CARRIERS; ENDOTHELIAL CELLS; FLUORESCENT DYES; MALE; MICE; MICE, INBRED C57BL; NANOPARTICLES; NITROBENZENES; OBESITY; OLIGOPEPTIDES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; REPRESSOR PROTEINS;

EID: 84866552156     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.09.002     Document Type: Article

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