Brain-Derived Neurotrophic Factor from Bone Marrow-Derived Cells Promotes Post-Injury Repair of Peripheral Nerve

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Takemura, Yoshinori ^a   Imai, Shinji ^a   Kojima, Hideto ^a   Katagi, Miwako ^a   Yamakawa, Isamu ^a   Kasahara, Toshiyuki ^a   Urabe, Hiroshi ^a   Terashima, Tomoya ^a   Yasuda, Hitoshi ^a   Chan, Lawrence ^b   Kimura, Hiroshi ^a   Matsusue, Yoshitaka ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CD45 ANTIGEN; GREEN FLUORESCENT PROTEIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CLIP; CONTROLLED STUDY; HETEROZYGOTE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOTOR NERVE CONDUCTION; MOUSE; NERVE CRUSH; NERVE FUNCTION; NERVE REGENERATION; NONHUMAN; PERIPHERAL NERVE INJURY; PROTEIN LOCALIZATION; RNA ANALYSIS; ROTAROD TEST; SCIATIC NERVE;

ANIMALS; BONE MARROW CELLS; BRAIN-DERIVED NEUROTROPHIC FACTOR; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PERIPHERAL NERVES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCIATIC NERVE; TRAUMA, NERVOUS SYSTEM;

MUS;

EID: 84866550799     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044592     Document Type: Article

References (31)

1. Seddon HJ, (1942) A Classification of Nerve Injuries. Br Med J 2: 237-239.
2. Barde YA, Edgar D, Thoenen H, (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J 1: 549-553.
3. Geremia NM, Pettersson LM, Hasmatali JC, Hryciw T, Danielsen N, et al. (2009) Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons. Exp Neurol.
4. Poblete-Naredo I, Guillem AM, Juarez C, Zepeda RC, Ramirez L, et al. (2011) Brain-derived neurotrophic factor and its receptors in Bergmann glia cells. Neurochem Int 59: 1133-1144.
5. Gorski JA, Zeiler SR, Tamowski S, Jones KR, (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23: 6856-6865.
6. Lindsay RM, (1988) Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons. J Neurosci 8: 2394-2405.
7. Boyd JG, Gordon T, (2003) Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Exp Neurol 183: 610-619.
8. Anton ES, Weskamp G, Reichardt LF, Matthew WD, (1994) Nerve growth factor and its low-affinity receptor promote Schwann cell migration. Proc Natl Acad Sci U S A 91: 2795-2799.
9. Meyer M, Matsuoka I, Wetmore C, Olson L, Thoenen H, (1992) Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J Cell Biol 119: 45-54.
10. Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, et al. (2005) BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438: 1017-1021.
11. Ernfors P, Lee KF, Jaenisch R, (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368: 147-150.
12. Cordeira J, Rios M, (2011) Weighing in the role of BDNF in the central control of eating behavior. Mol Neurobiol 44: 441-448.
13. Liu QR, Lu L, Zhu XG, Gong JP, Shaham Y, et al. (2006) Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res 1067: 1-12.
14. Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T, (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85: 525-535.
15. Walsh S, Midha R, (2009) Use of stem cells to augment nerve injury repair. Neurosurgery 65: A80-86.
16. Chen CJ, Ou YC, Liao SL, Chen WY, Chen SY, et al. (2007) Transplantation of bone marrow stromal cells for peripheral nerve repair. Exp Neurol 204: 443-453.
17. Elfar JC, Jacobson JA, Puzas JE, Rosier RN, Zuscik MJ, (2008) Erythropoietin accelerates functional recovery after peripheral nerve injury. J Bone Joint Surg Am 90: 1644-1653.
18. Kasahara T, Imai S, Kojima H, Katagi M, Kimura H, et al. (2010) Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice. Bone 47: 617-625.
19. Haastert K, Lipokatic E, Fischer M, Timmer M, Grothe C, (2006) Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol Dis 21: 138-153.
20. Ozmen S, Ayhan S, Latifoglu O, Siemionow M, (2002) Stamp and paper method: a superior technique for the walking track analysis. Plast Reconstr Surg 109: 1760-1761.
21. Bain JR, Mackinnon SE, Hunter DA, (1989) Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg 83: 129-138.
22. Sasaki M, Radtke C, Tan AM, Zhao P, Hamada H, et al. (2009) BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. J Neurosci 29: 14932-14941.
23. Tan AM, Stamboulian S, Chang YW, Zhao P, Hains AB, et al. (2008) Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury. J Neurosci 28: 13173-13183.
24. Fukuoka T, Kondo E, Dai Y, Hashimoto N, Noguchi K, (2001) Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model. J Neurosci 21: 4891-4900.
25. Lin YT, Ro LS, Wang HL, Chen JC, (2011) Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. J Neuroinflammation 8: 126.
26. Uchida K, Baba H, Maezawa Y, Furukawa S, Furusawa N, et al. (1998) Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factors. J Neurol 245: 781-793.
27. Garcia N, Tomas M, Santafe MM, Lanuza MA, Besalduch N, et al. (2010) Localization of brain-derived neurotrophic factor, neurotrophin-4, tropomyosin-related kinase b receptor, and p75 NTR receptor by high-resolution immunohistochemistry on the adult mouse neuromuscular junction. J Peripher Nerv Syst 15: 40-49.
28. Ladak A, Olson J, Tredget EE, Gordon T, (2011) Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model. Exp Neurol 228: 242-252.
29. Lopatina T, Kalinina N, Karagyaur M, Stambolsky D, Rubina K, et al. (2011) Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One 6: e17899.
30. Harris VK, Yan QJ, Vyshkina T, Sahabi S, Liu X, et al. (2012) Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis. J Neurol Sci.
31. Fu KY, Dai LG, Chiu IM, Chen JR, Hsu SH, (2011) Sciatic nerve regeneration by microporous nerve conduits seeded with glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor gene transfected neural stem cells. Artif Organs 35: 363-372.