Liver fat content is associated with increased carotid atherosclerosis in a Chinese middle-aged and elderly population: The Shanghai Changfeng study

Atherosclerosis

Volumn 224, Issue 2, 2012, Pages 480-485

  Li, Xiaoming ^a   Xia, Mingfeng ^a   Ma, Hui ^a   Hofman, Albert ^b   Hu, Yu ^a   Yan, Hongmei ^a   He, Wanyuan ^a   Lin, Huandong ^a   Jeekel, Johannes ^b   Zhao, Naiqing ^a   Gao, Jian ^a   Gao, Xin ^a  

^a FUDAN UNIVERSITY   (China)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Atherosclerosis (AS); Carotid intima media thickness (CIMT); Liver fat content (LFC); Nonalcoholic fatty liver disease (NAFLD); Ultrasonographic hepatic renal ratio (US H R ratio)

Indexed keywords

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; CAROTID ATHEROSCLEROSIS; CHINESE; DISEASE ASSOCIATION; DISEASE SEVERITY; ECHOGRAPHY; FATTY LIVER; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RISK ASSESSMENT;

AGE FACTORS; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CHINA; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84866539263     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.07.002     Document Type: Article

References (23)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002, 346:1221-1231.
2. Williams R. Global challenges in liver disease. Hepatology 2006, 44:521-526.
3. McCullough A.J. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004, 8:521-533. [viii].
4. Targher G., Bertolini L., Padovani R., Zenari L., Zoppini G., Falezza G. Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: role of visceral fat accumulation. Diabetes Care 2004, 27:2498-2500.
5. Brea A., Mosquera D., Martin E., Arizti A., Cordero J.L., Ros E. Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study. Arterioscler Thromb Vasc Biol 2005, 25:1045-1050.
6. Fracanzani A.L., Burdick L., Raselli S., et al. Carotid artery intima-media thickness in nonalcoholic fatty liver disease. Am J Med 2008, 121:72-78.
7. O'Leary D.H., Polak J.F. Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002, 90:18L-21L.
8. Soderberg C., Stal P., Askling J., et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology 2010, 51:595-602.
9. Adams L.A., Lymp J.F., St Sauver J., et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005, 129:113-121.
10. Gao X., Hofman A., Hu Y., et al. The Shanghai Changfeng Study: a community-based prospective cohort study of chronic diseases among middle-aged and elderly: objectives and design. Eur J Epidemiol 2010, 25:885-893.
11. Xia M.F., Yan H.M., He W.Y., et al. Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method. Obesity (Silver Spring) 2012, 20:444-452.
12. Nagai Y., Kitagawa K., Sakaguchi M., et al. Significance of earlier carotid atherosclerosis for stroke subtypes. Stroke 2001, 32:1780-1785.
13. Chobanian A.V., Bakris G.L., Black H.R., et al. Seventh report of the joint National committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003, 42:1206-1252.
14. Standards of medical care in diabetes-2010. Diabetes Care 2010, 33(SUPPL. 1):S11-S61.
15. Alberti K.G., Eckel R.H., Grundy S.M., et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645.
16. Szczepaniak L.S., Nurenberg P., Leonard D., et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005, 288:E462-E468.
17. Wong V.W., Chu W.C., Wong G.L., et al. Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut 2012, 61:409-415.
18. Targher G., Bertolini L., Padovani R., et al. Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease. Diabetes Care 2006, 29:1325-1330.
19. Targher G., Marra F., Marchesini G. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?. Diabetologia 2008, 51:1947-1953.
20. Nseir W., Taha H., Khateeb J., Grosovski M., Assy N. Fatty liver is associated with recurrent bacterial infections independent of metabolic syndrome. Dig Dis Sci 2011, 56:3328-3334.
21. Ndumele C.E., Nasir K., Conceicao R.D., Carvalho J.A., Blumenthal R.S., Santos R.D. Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased systemic inflammation. Arterioscler Thromb Vasc Biol 2011, 31:1927-1932.
22. Webb M., Yeshua H., Zelber-Sagi S., et al. Diagnostic value of a computerized hepatorenal index for sonographic quantification of liver steatosis. AJR Am J Roentgenol 2009, 192:909-914.
23. Mancini M., Prinster A., Annuzzi G., et al. Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy. Metabolism 2009, 58:1724-1730.