Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors

Breast Cancer Research and Treatment

Volumn 135, Issue 3, 2012, Pages 913-922

  Petrillo, Laura A ^a   Wolf, Denise M ^a   Kapoun, Ann M ^b   Wang, Nicholas J ^c   Barczak, Andrea ^d   Xiao, Yuanyuan ^d   Korkaya, Hasan ^e   Baehner, Frederick ^d   Lewicki, John ^b   Wicha, Max ^e   Park, John W ^a   Spellman, Paul T ^c   Gray, Joe W ^c   Van'T Veer, Laura ^a   Esserman, Laura J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OncoMed Pharmaceuticals Inc   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

ALDH1; Breast cancer; CDK5 6; Intrinsic subtype; Mouse model; PAM50; Receptor subtype; Xenograft

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER GRADING; CANCER RECURRENCE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE CLUSTER; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; MOUSE; NONHUMAN; PAM50 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; TUMOR CELL; TUMOR GENE; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOENZYMES; MICE; MICE, SCID; MULTIGENE FAMILY; RECEPTOR, ERBB-2; RETINAL DEHYDROGENASE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84866536411     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2226-y     Document Type: Article

References (26)

1. Giovanella B, Stehlin J, Williams L, Shih-Shun L, Shepard R (1978) Heterotransplantation of human cancers into nude mice. Cancer 42:2269-2281
2. Steel GG, Courtenay VD, Peckham MJ (1983) The response to chemotherapy of a variety of human tumour xenografts. Br J Cancer 47:001-013
3. Rae-Venter B, Reid LM (1980) Growth of human breast carcinomas in nude mice and subsequent establishment in tissue culture. Cancer Res 40:95-100 (Pubitemid 10179647)
4. Mehta R, Graves J, Hart G, Shilkaitis A, Das Gupta T (1993) Growth and metastasis of human breast carcinomas with Matrigel in athymic mice. Breast Cancer Res Treat 25:65-71 (Pubitemid 23107737)
5. Clarke R (1996) Human breast cancer cell line xenografts as models of breast cancer-the immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines. Breast Cancer Res Treat 39:69-86 (Pubitemid 26136505)
6. Pegram M, Ngo D (2006) Application and potential limitations of animal models utilized in the development of trastuzumab (Herceptin -): a case study. Adv Drug Deliv Rev 58(5-6):723-734 (Pubitemid 44247227)
7. Keller PJ et al (2010) Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res 12(5):R87
8. Reyal F et al (2012) Molecular profiling of patient-derived breast cancer xenografts. Breast Cancer Res 14(1):R11
9. Valdez KE et al (2011) Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model. J Pathol 225(4):565-573
10. Moestue SA et al (2010) Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models. BMC Cancer 10:433
11. Bergamaschi A et al (2009) Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models. Mol Oncol 3(5-6):469-482
12. Ding L et al (2010) Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464(7291):999-1005
13. Foulkes WD, Smith IE, Reis-Filho JS (2010) Triple negative breast cancer. N Engl J Med 363(20):1938-1948
14. Perou CM et al (2000) Molecular portraits of human breast tumours. Nature 406(6797):747-752
15. Resetkova E, Reis-Filho J, Jain RK, Mehta R, Thorat MA, Nakshatri H, Badve S (2010) Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment. Breast Cancer Res Treat 123(1):97-108
16. Ginestier C, Hur M, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1:555-567 (Pubitemid 350056407)
17. Dalerba P, Dylla SJ, Park I, Liu R, Wang X, Cho R, Hoey T, Gurney A, Huang E, Simeone D, Shelton A, Parmiani G, Castelli C, Clarke M (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci 104(24):10158-10163 (Pubitemid 47175279)
18. Bolstad BM et al (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19(2):185-193 (Pubitemid 36181903)
19. Smyth GK (2005) Limma: linear models for microarray data. In: Gentleman R et al (eds) Bioinformatics and computational biology solutions using R and bioconductor. Springer, New York
20. Parker JS, Michael M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, Quackenbush JF, Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS (2009) Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 27(8): 1160-1167
21. Seber GAF (1984) Multivariate observations. John Wiley & Sons, Hoboken, NJ
22. Weigelt B, Hu Z, He X, Livasy C, Carey LA, Ewend MG, Glas AM, Perou CM, Van't Veer LJ (2005) Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res 65(20):9155-9158 (Pubitemid 41507977)
23. Lonnstedt I, Speed T (2002) Replicated microarray data. Stat Sin 12(1):31-46
24. Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protocol 4(1):44-57
25. Marangoni E et al (2007) A new model of patient tumor-derived breast cancer xenografts for preclinical assays. Clin Cancer Res 13(13):3989-3998 (Pubitemid 47037607)
26. de Plater L et al (2010) Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation. Br J Cancer 103(8):1192-1200