Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Ide, Hiroki ^a   Kikuchi, Eiji ^a   Hasegawa, Masanori ^a   Kozakai, Norihide ^a   Kosaka, Takeo ^a   Miyajima, Akira ^a   Oya, Mototsugu ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 fluorouracil; Dihydropyrimidine dehydrogenase; S 1; Thymidylate synthase; Urothelial carcinoma

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; GIMERACIL; SMALL INTERFERING RNA; THYMIDYLATE SYNTHASE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CHEMOSENSITIVITY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SPECIFIC SURVIVAL; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IC 50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSITIONAL CELL CARCINOMA; TUMOR XENOGRAFT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; DIHYDROURACIL DEHYDROGENASE (NADP); DRUG SYNERGISM; FEMALE; FLUOROURACIL; HUMANS; MICE; MICE, INBRED BALB C; MIDDLE AGED; PROGNOSIS; PYRIDINES; RNA, SMALL INTERFERING; THYMIDYLATE SYNTHASE; UROLOGIC NEOPLASMS;

EID: 84866521672     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-420     Document Type: Article

References (30)

1. Oosterlinck W. Ureteral tumour: a specific upper urinary tract transitional cell carcinoma. Eur Urol 2007, 51:1164-1165. 10.1016/j.eururo.2006.11.050, 17161524.
2. Quek ML, Stein JP, Nichols PW, Cai J, Miranda G, Groshen S, Daneshmand S, Skinner EC, Skinner DG. Prognostic significance of lymphovascular invasion of bladder cancer treated with radical cystectomy. J Urol 2005, 174:103-106. 10.1097/01.ju.0000163267.93769.d8, 15947587.
3. Margulis V, Shariat SF, Matin SF, Kamat AM, Zigeuner R, Kikuchi E, Lotan Y, Weizer A, Raman JD, Wood CG. Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma Collaboration. Cancer 2009, 115:1224-1233. 10.1002/cncr.24135, 19156917.
4. Von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM, Conte PF, et al. Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol 2000, 18:3068-3077.
5. Von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A, Arning M. Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol 2005, 23:4602-4608. 10.1200/JCO.2005.07.757, 16034041.
6. Sternberg CN, de Mulder P, Schornagel JH, Theodore C, Fossa SD, van Oosterom AT, Witjes JA, Spina M, van Groeningen CJ, Duclos B, Roberts JT, de Balincourt C, Collette L. Seven year update of an EORTC phase III trial of high-dose intensity M-VAC chemotherapy and G-CSF versus classic M-VAC in advanced urothelial tract tumours. Eur J Cancer 2006, 42:50-54. 10.1016/j.ejca.2005.08.032, 16330205.
7. Langenbach RJ, Danenberg PV, Heidelberger C. Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate. Biochem Biophys Res Commun 1972, 48:1565-1571. 10.1016/0006-291X(72)90892-3, 4263280.
8. Peters GJ, van der Wilt CL, van Triest B, Codacci-Pisanelli G, Johnston PG, van Groeningen CJ, Pinedo HM. Thymidylate synthase and drug resistance. Eur J Cancer 1995, 31A:1299-1305.
9. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. J Histochem Cytochem 1999, 47:1563-1574. 10.1177/002215549904701208, 10567440.
10. Li Y, Li X, Dai H, Sun X, Li J, Yang F, Gu H, Yang Y, Jin Z, Chu Y, Jin X, Kakehi Y, Wu X. Thymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer. BJU Int 2009, 103:547-552. 10.1111/j.1464-410X.2008.08099.x, 18990150.
11. Kuniyasu T, Nakamura T, Tabuchi Y, Kuroda Y. Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody: the clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness. Cancer 1998, 83:1300-1306. 10.1002/(SICI)1097-0142(19981001)83:7<1300::AID-CNCR5>3.0.CO;2-M, 9762929.
12. Yamachika T, Nakanishi H, Inada K, Tsukamoto T, Kato T, Fukushima M, Inoue M, Tatematsu M. A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance. Cancer 1998, 82:70-77. 10.1002/(SICI)1097-0142(19980101)82:1<70::AID-CNCR8>3.0.CO;2-O, 9428481.
13. Mizutani Y, Wada H, Ogawa O, Yoshida O, Fukushima M, Nonomura N, Miki T. Prognostic significance of thymidylate synthase activity in bladder carcinoma. Cancer 2001, 92:510-518. 10.1002/1097-0142(20010801)92:3<510::AID-CNCR1349>3.0.CO;2-0, 11505394.
14. Heggie GD, Sommadossi JP, Cross DS, Huster WJ, Diasio RB. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 1987, 47:2203-2206.
15. Tsutani Y, Yoshida K, Sanada Y, Oeda M, Suzuki T, Hihara J, Okada M. Dihydropyrimidine dehydrogenase and orotate phosphoribosyltransferase in esophageal cancer patients: Correlation with clinicopathological factors and prognosis. Mol Med Report 2008, 1:713-719.
16. Mizutani Y, Wada H, Fukushima M, Yoshida O, Ukimura O, Kawauchi A, Miki T. The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer. Eur J Cancer 2001, 37:569-575. 10.1016/S0959-8049(00)00440-8, 11290431.
17. Horiguchi J, Yoshida T, Koibuchi Y, Iijima K, Ninomiya J, Takei H, Yokoe T, Iino Y, Morishita Y. DPD activity and immunohistochemical DPD expression in human breast cancer. Oncol Rep 2004, 11:65-72.
18. Hotta T, Takifuji K, Taniguchi K, Sahara M, Yokoyama S, Matsuda K, Higashiguchi T, Tominaga T, Oku Y, Yamaue H. The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer. Oncol Rep 2006, 16:177-182.
19. Johnston PG, Fisher ER, Rockette HE, Fisher B, Wolmark N, Drake JC, Chabner BA, Allegra CJ. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 1994, 12:2640-2647.
20. Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, Leichman L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995, 55:1407-1412.
21. Lenz HJ, Leichman CG, Danenberg KD, Danenberg PV, Groshen S, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Garcia Y, Li J, Leichman L. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol 1996, 14:176-182.
22. Beck A, Etienne MC, Chéradame S, Fischel JL, Formento P, Renée N, Milano G. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur J Cancer 1994, 30A:1517-1522.
23. Ishikawa Y, Kubota T, Otani Y, Watanabe M, Teramoto T, Kumai K, Kitajima M, Takechi T, Okabe H, Fukushima M. Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice. Clin Cancer Res 1999, 5:883-889.
24. Etienne MC, Chéradame S, Fischel JL, Formento P, Dassonville O, Renée N, Schneider M, Thyss A, Demard F, Milano G. Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity. J Clin Oncol 1995, 13:1663-1670.
25. Takechi T, Fujioka A, Matsushima E, Fukushima M. Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer 2002, 38:1271-1277. 10.1016/S0959-8049(02)00048-5, 12044515.
26. Kubota Y, Noguchi S, Hosaka M. UFT in bladder cancer. Oncology (Williston Park) 1999, 13:112-115.
27. Furuse H, Hirano Y, Harada M, Ming LH, Aoki T, Kurita Y, Mugiya S, Ushiyama T, Ozono S. Significance of 5-fluorouracil-related enzyme activities in predicting sensitivity to 5-fluorouracil in bladder carcinoma. Anticancer Res 2009, 29:1001-1008.
28. Epstein JI, Amin MB, Reuter VR, Mostofi FK. The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am J Surg Pathol 1998, 22:1435-1448. 10.1097/00000478-199812000-00001, 9850170.
29. Nomura T, Nakagawa M, Fujita Y, Hanada T, Mimata H, Nomura Y. Clinical significance of thymidylate synthase expression in bladder cancer. Int J Urol 2002, 9:368-376. 10.1046/j.1442-2042.2002.00479.x, 12165018.
30. Mauritz R, van Groeningen CJ, Smid K, Jansen G, Pinedo HM, Peters GJ. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer. Int J Cancer 2007, 120:2609-2612. 10.1002/ijc.22626, 17330233.