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Volumn 7, Issue 9, 2012, Pages

Double Stranded Sperm DNA Breaks, Measured by Comet Assay, Are Associated with Unexplained Recurrent Miscarriage in Couples without a Female Factor

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[No Author keywords available]

Indexed keywords

NUCLEASE;

EID: 84866517445     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044679     Document Type: Article
Times cited : (107)

References (53)
  • 1
    • 84875120074 scopus 로고    scopus 로고
    • American Society for Reproductive Medicine (ASRM), Avaliable
    • American Society for Reproductive Medicine (ASRM) (2008) Recurrent pregnancy loss Patient Fact Sheet. Avaliable: http://www.asrm.org/Guidelines/.
    • (2008) Recurrent pregnancy loss Patient Fact Sheet
  • 3
    • 0030945067 scopus 로고    scopus 로고
    • Male infertility
    • de Kretser DM, (1997) Male infertility. Lancet 349(9054): 787-790.
    • (1997) Lancet , vol.349 , Issue.9054 , pp. 787-790
    • de Kretser, D.M.1
  • 4
    • 78649974540 scopus 로고    scopus 로고
    • Clinical implications of sperm DNA damage
    • Lewis SE, Simon L, (2010) Clinical implications of sperm DNA damage. Hum Fertil (Camb) 13(4): 201-207.
    • (2010) Hum Fertil (Camb) , vol.13 , Issue.4 , pp. 201-207
    • Lewis, S.E.1    Simon, L.2
  • 5
    • 1542287296 scopus 로고    scopus 로고
    • Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis
    • Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT, (2004) Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Intern Med 164(5): 558-563.
    • (2004) Arch Intern Med , vol.164 , Issue.5 , pp. 558-563
    • Kovalevsky, G.1    Gracia, C.R.2    Berlin, J.A.3    Sammel, M.D.4    Barnhart, K.T.5
  • 6
    • 84921705962 scopus 로고    scopus 로고
    • Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant
    • Empson M, Lassere M, Craig J, Scott J, (2005) Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev 18 (2)(2): CD002859.
    • (2005) Cochrane Database Syst Rev , vol.18 , Issue.2
    • Empson, M.1    Lassere, M.2    Craig, J.3    Scott, J.4
  • 8
    • 31144473094 scopus 로고    scopus 로고
    • Anatomic factors in recurrent pregnancy loss
    • Devi Wold AS, Pham N, Arici A, (2006) Anatomic factors in recurrent pregnancy loss. Semin Reprod Med 24(1): 25-32.
    • (2006) Semin Reprod Med , vol.24 , Issue.1 , pp. 25-32
    • Devi Wold, A.S.1    Pham, N.2    Arici, A.3
  • 9
    • 34547830245 scopus 로고    scopus 로고
    • Is sperm evaluation useful in predicting human fertility?
    • Lewis SE, (2007) Is sperm evaluation useful in predicting human fertility? Reproduction 134(1): 31-40.
    • (2007) Reproduction , vol.134 , Issue.1 , pp. 31-40
    • Lewis, S.E.1
  • 10
    • 77956184105 scopus 로고    scopus 로고
    • Assessment of sperm factors possibly involved in early recurrent pregnancy loss
    • Gil-Villa AM, Cardona-Maya W, Agarwal A, Sharma R, Cadavid A, (2010) Assessment of sperm factors possibly involved in early recurrent pregnancy loss. Fertil Steril 94(4): 1465-1472.
    • (2010) Fertil Steril , vol.94 , Issue.4 , pp. 1465-1472
    • Gil-Villa, A.M.1    Cardona-Maya, W.2    Agarwal, A.3    Sharma, R.4    Cadavid, A.5
  • 11
    • 80053916733 scopus 로고    scopus 로고
    • Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss
    • Brahem S, Mehdi M, Landolsi H, Mougou S, Elghezal H, et al. (2011) Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss. Urology 78(4): 792-796.
    • (2011) Urology , vol.78 , Issue.4 , pp. 792-796
    • Brahem, S.1    Mehdi, M.2    Landolsi, H.3    Mougou, S.4    Elghezal, H.5
  • 12
    • 84857639939 scopus 로고    scopus 로고
    • Value of sperm chromatin dispersion test in couples with unexplained recurrent abortion
    • Absalan F, Ghannadi A, Kazerooni M, Parifar R, Jamalzadeh F, et al. (2012) Value of sperm chromatin dispersion test in couples with unexplained recurrent abortion. J Assist Reprod Genet 29(1): 11-14.
    • (2012) J Assist Reprod Genet , vol.29 , Issue.1 , pp. 11-14
    • Absalan, F.1    Ghannadi, A.2    Kazerooni, M.3    Parifar, R.4    Jamalzadeh, F.5
  • 14
    • 57149140106 scopus 로고    scopus 로고
    • Y chromosome azoospermia factor region microdeletions and recurrent pregnancy loss
    • Karaer A, Karaer K, Ozaksit G, Ceylaner S, Percin EF, (2008) Y chromosome azoospermia factor region microdeletions and recurrent pregnancy loss. Am J Obstet Gynecol 199(6): 662.e1-662.e5.
    • (2008) Am J Obstet Gynecol , vol.199 , Issue.6
    • Karaer, A.1    Karaer, K.2    Ozaksit, G.3    Ceylaner, S.4    Percin, E.F.5
  • 15
    • 77955916849 scopus 로고    scopus 로고
    • Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology
    • Bellver J, Meseguer M, Muriel L, Garcia-Herrero S, Barreto MA, et al. (2010) Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology. Hum Reprod 25(7): 1713-1721.
    • (2010) Hum Reprod , vol.25 , Issue.7 , pp. 1713-1721
    • Bellver, J.1    Meseguer, M.2    Muriel, L.3    Garcia-Herrero, S.4    Barreto, M.A.5
  • 17
    • 11144238934 scopus 로고    scopus 로고
    • Sperm chromosomal abnormalities in patients with unexplained recurrent abortions
    • Al-Hassan S, Hellani A, Al-Shahrani A, Al-Deery M, Jaroudi K, et al. (2005) Sperm chromosomal abnormalities in patients with unexplained recurrent abortions. Arch Androl 51(1): 69-76.
    • (2005) Arch Androl , vol.51 , Issue.1 , pp. 69-76
    • Al-Hassan, S.1    Hellani, A.2    Al-Shahrani, A.3    Al-Deery, M.4    Jaroudi, K.5
  • 18
    • 84875099051 scopus 로고    scopus 로고
    • TEM and FISH studies in sperm from men of couples with recurrent pregnancy loss; Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss
    • Collodel G, Giannerini V, Antonio Pascarelli N, Federico MG, Comodo F, et al. (2011) TEM and FISH studies in sperm from men of couples with recurrent pregnancy loss; Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss. Urology 41;78(6; 4): 352; 792-360; 796.
    • (2011) Urology , vol.41-78 , Issue.4-6
    • Collodel, G.1    Giannerini, V.2    Antonio Pascarelli, N.3    Federico, M.G.4    Comodo, F.5
  • 19
    • 79961176317 scopus 로고    scopus 로고
    • Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss
    • Carrell DT, Liu L, Peterson CM, Jones KP, Hatasaka HH, et al. (2003) Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss. Arch Androl 49(1): 49-55.
    • (2003) Arch Androl , vol.49 , Issue.1 , pp. 49-55
    • Carrell, D.T.1    Liu, L.2    Peterson, C.M.3    Jones, K.P.4    Hatasaka, H.H.5
  • 20
    • 0018899119 scopus 로고
    • Comparison of human and mouse sperm chromatin structure by flow cytometry
    • Evenson DP, Darzynkiewicz Z, Melamed MR, (1980) Comparison of human and mouse sperm chromatin structure by flow cytometry. Chromosoma 78(2): 225-238.
    • (1980) Chromosoma , vol.78 , Issue.2 , pp. 225-238
    • Evenson, D.P.1    Darzynkiewicz, Z.2    Melamed, M.R.3
  • 21
    • 0035665312 scopus 로고    scopus 로고
    • Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques
    • Evenson DP, Larson KL, Jost LK, (2002) Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 23(1): 25-43.
    • (2002) J Androl , vol.23 , Issue.1 , pp. 25-43
    • Evenson, D.P.1    Larson, K.L.2    Jost, L.K.3
  • 22
    • 0027269557 scopus 로고
    • Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays
    • Gorczyca W, Gong J, Darzynkiewicz Z, (1993) Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53(8): 1945-1951.
    • (1993) Cancer Res , vol.53 , Issue.8 , pp. 1945-1951
    • Gorczyca, W.1    Gong, J.2    Darzynkiewicz, Z.3
  • 23
    • 0034469287 scopus 로고    scopus 로고
    • Sperm chromatin structure assay is useful for fertility assessment
    • Evenson D, Jost L, (2000) Sperm chromatin structure assay is useful for fertility assessment. Methods Cell Sci 22(2-3): 169-189.
    • (2000) Methods Cell Sci , vol.22 , Issue.2-3 , pp. 169-189
    • Evenson, D.1    Jost, L.2
  • 24
    • 26244435244 scopus 로고    scopus 로고
    • Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test
    • Fernandez JL, Muriel L, Goyanes V, Segrelles E, Gosalvez J, et al. (2005) Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test. Fertil Steril 84(4): 833-842.
    • (2005) Fertil Steril , vol.84 , Issue.4 , pp. 833-842
    • Fernandez, J.L.1    Muriel, L.2    Goyanes, V.3    Segrelles, E.4    Gosalvez, J.5
  • 25
    • 77955649218 scopus 로고    scopus 로고
    • TUNEL as a test for sperm DNA damage in the evaluation of male infertility
    • Sharma RK, Sabanegh E, Mahfouz R, Gupta S, Thiyagarajan A, et al. (2010) TUNEL as a test for sperm DNA damage in the evaluation of male infertility. Urology 76(6): 1380-1386.
    • (2010) Urology , vol.76 , Issue.6 , pp. 1380-1386
    • Sharma, R.K.1    Sabanegh, E.2    Mahfouz, R.3    Gupta, S.4    Thiyagarajan, A.5
  • 26
    • 78651297184 scopus 로고    scopus 로고
    • The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: development of an improved methodology
    • Mitchell LA, De Iuliis GN, Aitken RJ, (2011) The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: development of an improved methodology. Int J Androl 34(1): 2-13.
    • (2011) Int J Androl , vol.34 , Issue.1 , pp. 2-13
    • Mitchell, L.A.1    de Iuliis, G.N.2    Aitken, R.J.3
  • 27
    • 0038799736 scopus 로고    scopus 로고
    • Oxidative DNA damage: mechanisms, mutation, and disease
    • Cooke MS, Evans MD, Dizdaroglu M, Lunec J, (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17(10): 1195-1214.
    • (2003) FASEB J , vol.17 , Issue.10 , pp. 1195-1214
    • Cooke, M.S.1    Evans, M.D.2    Dizdaroglu, M.3    Lunec, J.4
  • 28
    • 58149289746 scopus 로고    scopus 로고
    • Biological and clinical significance of DNA damage in the male germ line
    • Aitken RJ, De Iuliis GN, McLachlan RI, (2009) Biological and clinical significance of DNA damage in the male germ line. Int J Androl 32(1): 46-56.
    • (2009) Int J Androl , vol.32 , Issue.1 , pp. 46-56
    • Aitken, R.J.1    de Iuliis, G.N.2    McLachlan, R.I.3
  • 29
    • 37349018261 scopus 로고    scopus 로고
    • Clinical relevance of oxidative stress in male factor infertility: an update
    • Agarwal A, Makker K, Sharma R, (2008) Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 59(1): 2-11.
    • (2008) Am J Reprod Immunol , vol.59 , Issue.1 , pp. 2-11
    • Agarwal, A.1    Makker, K.2    Sharma, R.3
  • 30
    • 70149120824 scopus 로고    scopus 로고
    • Oxidative stress & male infertility
    • Makker K, Agarwal A, Sharma R, (2009) Oxidative stress & male infertility. Indian J Med Res 129(4): 357-367.
    • (2009) Indian J Med Res , vol.129 , Issue.4 , pp. 357-367
    • Makker, K.1    Agarwal, A.2    Sharma, R.3
  • 31
    • 77649219526 scopus 로고    scopus 로고
    • On the possible origins of DNA damage in human spermatozoa
    • Aitken RJ, De Iuliis GN, (2010) On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod 16(1): 3-13.
    • (2010) Mol Hum Reprod , vol.16 , Issue.1 , pp. 3-13
    • Aitken, R.J.1    de Iuliis, G.N.2
  • 32
    • 78650751584 scopus 로고    scopus 로고
    • Apoptosis and DNA damage in human spermatozoa
    • Aitken RJ, Koppers AJ, (2011) Apoptosis and DNA damage in human spermatozoa. Asian J Androl 13(1): 36-42.
    • (2011) Asian J Androl , vol.13 , Issue.1 , pp. 36-42
    • Aitken, R.J.1    Koppers, A.J.2
  • 33
    • 0031413880 scopus 로고    scopus 로고
    • Activation of endogenous nucleases in mature sperm cells upon interaction with exogenous DNA
    • Maione B, Pittoggi C, Achene L, Lorenzini R, Spadafora C, (1997) Activation of endogenous nucleases in mature sperm cells upon interaction with exogenous DNA. DNA Cell Biol 16(9): 1087-1097.
    • (1997) DNA Cell Biol , vol.16 , Issue.9 , pp. 1087-1097
    • Maione, B.1    Pittoggi, C.2    Achene, L.3    Lorenzini, R.4    Spadafora, C.5
  • 34
    • 0030949651 scopus 로고    scopus 로고
    • Effects of heat stress on mouse testicular cells and sperm chromatin structure
    • Sailer BL, Sarkar LJ, Bjordahl JA, Jost LK, Evenson DP, (1997) Effects of heat stress on mouse testicular cells and sperm chromatin structure. J Androl 18(3): 294-301.
    • (1997) J Androl , vol.18 , Issue.3 , pp. 294-301
    • Sailer, B.L.1    Sarkar, L.J.2    Bjordahl, J.A.3    Jost, L.K.4    Evenson, D.P.5
  • 35
    • 0345601178 scopus 로고    scopus 로고
    • Ability of hamster spermatozoa to digest their own DNA
    • Sotolongo B, Lino E, Ward WS, (2003) Ability of hamster spermatozoa to digest their own DNA. Biol Reprod 69(6): 2029-2035.
    • (2003) Biol Reprod , vol.69 , Issue.6 , pp. 2029-2035
    • Sotolongo, B.1    Lino, E.2    Ward, W.S.3
  • 36
    • 14344256084 scopus 로고    scopus 로고
    • An endogenous nuclease in hamster, mouse, and human spermatozoa cleaves DNA into loop-sized fragments
    • Sotolongo B, Huang TT, Isenberger E, Ward WS, (2005) An endogenous nuclease in hamster, mouse, and human spermatozoa cleaves DNA into loop-sized fragments. J Androl 26(2): 272-280.
    • (2005) J Androl , vol.26 , Issue.2 , pp. 272-280
    • Sotolongo, B.1    Huang, T.T.2    Isenberger, E.3    Ward, W.S.4
  • 37
    • 77649211158 scopus 로고    scopus 로고
    • Function of sperm chromatin structural elements in fertilization and development
    • Ward WS, (2010) Function of sperm chromatin structural elements in fertilization and development. Mol Hum Reprod 16(1): 30-36.
    • (2010) Mol Hum Reprod , vol.16 , Issue.1 , pp. 30-36
    • Ward, W.S.1
  • 38
    • 14644397349 scopus 로고    scopus 로고
    • Nature of telomere dimers and chromosome looping in human spermatozoa
    • Solov'eva L, Svetlova M, Bodinski D, Zalensky AO, (2004) Nature of telomere dimers and chromosome looping in human spermatozoa. Chromosome Res 12(8): 817-823.
    • (2004) Chromosome Res , vol.12 , Issue.8 , pp. 817-823
    • Solov'eva, L.1    Svetlova, M.2    Bodinski, D.3    Zalensky, A.O.4
  • 39
    • 1542313790 scopus 로고    scopus 로고
    • Non-random positioning of chromosomes in human sperm nuclei
    • Zalenskaya IA, Zalensky AO, (2004) Non-random positioning of chromosomes in human sperm nuclei. Chromosome Res 12(2): 163-173.
    • (2004) Chromosome Res , vol.12 , Issue.2 , pp. 163-173
    • Zalenskaya, I.A.1    Zalensky, A.O.2
  • 40
    • 27644474250 scopus 로고    scopus 로고
    • Chromosome architecture in the decondensing human sperm nucleus
    • Mudrak O, Tomilin N, Zalensky A, (2005) Chromosome architecture in the decondensing human sperm nucleus. J Cell Sci 118(Pt 19): 4541-4550.
    • (2005) J Cell Sci , vol.118 , Issue.Pt 19 , pp. 4541-4550
    • Mudrak, O.1    Tomilin, N.2    Zalensky, A.3
  • 41
    • 84857210779 scopus 로고    scopus 로고
    • Alkaline and neutral Comet assay profiles of sperm DNA damage in clinical groups
    • Ribas-Maynou J, Garcia-Peiro A, Abad C, Amengual MJ, Navarro J, et al. (2012) Alkaline and neutral Comet assay profiles of sperm DNA damage in clinical groups. Hum Reprod 27(3): 652-658.
    • (2012) Hum Reprod , vol.27 , Issue.3 , pp. 652-658
    • Ribas-Maynou, J.1    Garcia-Peiro, A.2    Abad, C.3    Amengual, M.J.4    Navarro, J.5
  • 43
    • 81455154653 scopus 로고    scopus 로고
    • Dynamics of sperm DNA fragmentation in patients carrying structurally rearranged chromosomes
    • Garcia-Peiro A, Oliver-Bonet M, Navarro J, Abad C, Guitart M, et al. (2011) Dynamics of sperm DNA fragmentation in patients carrying structurally rearranged chromosomes. Int J Androl 34(6 Pt 2): e546-53.
    • (2011) Int J Androl , vol.34 , Issue.6 Pt 2
    • Garcia-Peiro, A.1    Oliver-Bonet, M.2    Navarro, J.3    Abad, C.4    Guitart, M.5
  • 44
    • 27944478245 scopus 로고    scopus 로고
    • DNA damage to spermatozoa has impacts on fertilization and pregnancy
    • Lewis SE, Aitken RJ, (2005) DNA damage to spermatozoa has impacts on fertilization and pregnancy. Cell Tissue Res 322(1): 33-41.
    • (2005) Cell Tissue Res , vol.322 , Issue.1 , pp. 33-41
    • Lewis, S.E.1    Aitken, R.J.2
  • 45
    • 79956100417 scopus 로고    scopus 로고
    • Sperm DNA damage or progressive motility: which one is the better predictor of fertilization in vitro?
    • Simon L, Lewis SE, (2011) Sperm DNA damage or progressive motility: which one is the better predictor of fertilization in vitro? Syst Biol Reprod Med 57(3): 133-138.
    • (2011) Syst Biol Reprod Med , vol.57 , Issue.3 , pp. 133-138
    • Simon, L.1    Lewis, S.E.2
  • 46
    • 78651379641 scopus 로고    scopus 로고
    • Are sperm chromatin and DNA defects relevant in the clinic?
    • Zini A, (2011) Are sperm chromatin and DNA defects relevant in the clinic? Syst Biol Reprod Med 57(1-2): 78-85.
    • (2011) Syst Biol Reprod Med , vol.57 , Issue.1-2 , pp. 78-85
    • Zini, A.1
  • 47
    • 78751574154 scopus 로고    scopus 로고
    • Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success
    • Simon L, Lutton D, McManus J, Lewis SE, (2011) Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success. Fertil Steril 95(2): 652-657.
    • (2011) Fertil Steril , vol.95 , Issue.2 , pp. 652-657
    • Simon, L.1    Lutton, D.2    McManus, J.3    Lewis, S.E.4
  • 48
    • 77950004985 scopus 로고    scopus 로고
    • Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications-a position report
    • Barratt CL, Aitken RJ, Bjorndahl L, Carrell DT, de Boer P, et al. (2010) Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications-a position report. Hum Reprod 25(4): 824-838.
    • (2010) Hum Reprod , vol.25 , Issue.4 , pp. 824-838
    • Barratt, C.L.1    Aitken, R.J.2    Bjorndahl, L.3    Carrell, D.T.4    de Boer, P.5
  • 49
    • 55149097676 scopus 로고    scopus 로고
    • Sperm deoxyribonucleic acid fragmentation as assessed by the sperm chromatin dispersion test in assisted reproductive technology programs: results of a large prospective multicenter study
    • Velez de la Calle JF, Muller A, Walschaerts M, Clavere JL, Jimenez C, et al. (2008) Sperm deoxyribonucleic acid fragmentation as assessed by the sperm chromatin dispersion test in assisted reproductive technology programs: results of a large prospective multicenter study. Fertil Steril 90(5): 1792-1799.
    • (2008) Fertil Steril , vol.90 , Issue.5 , pp. 1792-1799
    • de la Calle, J.F.V.1    Muller, A.2    Walschaerts, M.3    Clavere, J.L.4    Jimenez, C.5
  • 50
    • 42449105332 scopus 로고    scopus 로고
    • Oxidative stress and male infertility - a clinical perspective
    • Tremellen K, (2008) Oxidative stress and male infertility - a clinical perspective. Hum Reprod Update 14(3): 243-258.
    • (2008) Hum Reprod Update , vol.14 , Issue.3 , pp. 243-258
    • Tremellen, K.1
  • 51
    • 34447133682 scopus 로고    scopus 로고
    • Paternal Pronuclear DNA Degradation Is Functionally Linked to DNA Replication in Mouse Oocytes
    • Yamauchi Y, Shaman JA, Boaz SM, Ward WS, (2007) Paternal Pronuclear DNA Degradation Is Functionally Linked to DNA Replication in Mouse Oocytes. Biol Reprod. 9(77): 407-415.
    • (2007) Biol Reprod , vol.9 , Issue.77 , pp. 407-415
    • Yamauchi, Y.1    Shaman, J.A.2    Boaz, S.M.3    Ward, W.S.4
  • 52
    • 43449084348 scopus 로고    scopus 로고
    • The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor
    • Meseguer M, Martínez-Conejero JA, O'Connor JE, Pellicer A, Remohí J, et al. (2008) The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor. Fertil Steril 89(5): 1191-1199.
    • (2008) Fertil Steril , vol.89 , Issue.5 , pp. 1191-1199
    • Meseguer, M.1    Martínez-Conejero, J.A.2    O'Connor, J.E.3    Pellicer, A.4    Remohí, J.5
  • 53
    • 77049084953 scopus 로고    scopus 로고
    • Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis
    • Sakkas D, Alvarez JG, (2010) Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil Steril 93(4): 1027-1036.
    • (2010) Fertil Steril , vol.93 , Issue.4 , pp. 1027-1036
    • Sakkas, D.1    Alvarez, J.G.2


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