High glucose mediates endothelial-to-chondrocyte transition in human aortic endothelial cells

Cardiovascular Diabetology

Volumn 11, Issue , 2012, Pages

  Tang, Rining ^a   Gao, Min ^a   Wu, Min ^a   Liu, Hong ^a   Zhang, Xiaoliang ^a   Liu, Bicheng ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Endothelial to mesenchymal transition; High glucose; Mesenchymal stem cells; Snail; Vascular calcification

Indexed keywords

CALVASCULIN; CD31 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; GLUCOSE; HERMES ANTIGEN; TRANSCRIPTION FACTOR SOX9;

ARTICLE; CALCIFICATION; CARTILAGE CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MESENCHYMAL STEM CELL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIGENS, CD31; ANTIGENS, CD44; ANTIGENS, SURFACE; AORTA; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; CHONDROCYTES; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GLUCOSE; HUMANS; MESENCHYMAL STROMAL CELLS; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; NEPRILYSIN; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; SOX9 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; VASCULAR CALCIFICATION;

EID: 84866506325     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-11-113     Document Type: Article

References (31)

1. Saleh N, Petursson P, Lagerqvist B, Skúladóttir H, Svensson A, Eliasson B, Gudbjörnsdottir S, Eeg-Olofsson K, Norhammar A. Long-term mortality in patients with type 2 diabetes undergoing coronary angiography: the impact of glucose-lowering treatment. Diabetologia 2012, 55:2109-2117. 10.1007/s00125-012-2565-6, 22566103.
2. Rennenberg RJ, Kessels AG, Schurgers LJ, van Engelshoven JM, de Leeuw PW, Kroon AA. Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. Vasc Health Risk Manag 2009, 5:185-197. 2672434, 19436645.
3. Patel T, Charytan DM. Cardiovascular complications in diabetic kidney disease. Semin Dial 2010, 23:169-177. 10.1111/j.1525-139X.2009.00704.x, 20210914.
4. Neven E, Dauwe S, De Broe ME, D'Haese PC, Persy V. Endochondral bone formation is involved in media calcification in rats and in men. Kidney Int 2007, 72:574-581. 10.1038/sj.ki.5002353, 17538568.
5. Sage AP, Tintut Y, Demer LL. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol 2010, 7:528-536. 10.1038/nrcardio.2010.115, 3014092, 20664518.
6. Farrington-Rock C, Crofts NJ, Doherty MJ, Ashton BA, Griffin-Jones C, Canfield AE. Chondrogenic and adipogenic potential of microvascular pericytes. Circulation 2004, 110:2226-2232. 10.1161/01.CIR.0000144457.55518.E5, 15466630.
7. Speer MY, Yang HY, Brabb T, Leaf E, Look A, Lin WL, Frutkin A, Dichek D, Giachelli CM. Smooth muscle cells give rise ot osteochondrogenic precursors and chondrocyte in calcifying arteries. Circ Res 2009, 104:733-741. 10.1161/CIRCRESAHA.108.183053, 2716055, 19197075.
8. Frid MG, Kale VA, Stenmark KR. Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circ Res 2002, 90:1189-1196. 10.1161/01.RES.0000021432.70309.28, 12065322.
9. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008, 19:2282-2287. 10.1681/ASN.2008050513, 2588112, 18987304.
10. Li J, Qu X, Yao J, Caruana G, Ricardo SD, Yamamoto Y, Yamamoto H, Bertram JF. Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes 2010, 59:2612-2624. 10.2337/db09-1631, 3279546, 20682692.
11. Widyantoro B, Emoto N, Nakayama K, Anggrahini DW, Adiarto S, Iwasa N, Yagi K, Miyagawa K, Rikitake Y, Suzuki T, Kisanuki YY, Yanagisawa M, Hirata K. Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation 2010, 121:2407-2418. 10.1161/CIRCULATIONAHA.110.938217, 20497976.
12. Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascualr endothelial cells into multipotent stem-like cells. Nat Med 2010, 16:1400-1406. 10.1038/nm.2252, 3209716, 21102460.
13. Neven E, Persy V, Dauwe S, De Schutter T, De Broe ME, D'Haese PC. Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats. Arterioscler Thromb Vasc Biol 2010, 30:1741-1750. 10.1161/ATVBAHA.110.204834, 20522801.
14. Chen NX, Duan D, O'Neill KD, Moe SM. High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells. Nephrol Dial Transplant 2006, 21:3435-3442. 10.1093/ndt/gfl429, 17005530.
15. Boström KI, Jumabay M, Matveyenko A, Nicholas SB, Yao Y. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res 2011, 108:446-457. 10.1161/CIRCRESAHA.110.236596, 3042480, 21193740.
16. Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y. High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol 2011, 4:73.
17. Thomsen SB, Rathcke CN, Zerahn B, Vestergaard H. Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease. Cardiovasc Diabetol 2010, 9:86. 10.1186/1475-2840-9-86, 3016330, 21143859.
18. Tang R, Li Q, Lv L, Dai H, Zheng M, Ma K, Liu B. Angiotensin II mediates the high-glucose-induced endothelial-to-mesenchymal transition in human aortic endothelial cells. Cardiovasc Diabetol 2010, 9:31. 10.1186/1475-2840-9-31, 2920267, 20663195.
19. Tang RN, Lv LL, Zhang JD, Dai HY, Li Q, Zheng M, Ni J, Ma KL, Liu BC. Effect of angiotensis II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats. Int J Cardio 2011, in press.
20. Moe SM, Chen NX. Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 2008, 19:213-216. 10.1681/ASN.2007080854, 18094365.
21. Horwitz EM. Building bone from blood vessels. Nat Med 2010, 16:1373-1374. 10.1038/nm1210-1373, 21135844.
22. Medici D, Kalluri R. Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype. Semin Cancer Biol 2012, in press.
23. Shoshani O, Zipori D. Transition of endothelium to cartilage and bone. Cell Stem Cell 2011, 8:10-11. 10.1016/j.stem.2010.12.004, 21211778.
24. Slukvin II, Vodyanik M. Endothelial origin of mesenchymal stem cells. Cell Cycle 2011, 10:1370-1373. 10.4161/cc.10.9.15345, 3117041, 21444996.
25. Kissa K, Herbomel P. Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature 2010, 464:112-115. 10.1038/nature08761, 20154732.
26. Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Watabe T, Miyazono K. Snail is required for TGF beta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J Cell Sci 2008, 121:3317-3324. 10.1242/jcs.028282, 18796538.
27. Medici D, Potenta S, Kalluri R. Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochem J 2011, 437:515-520. 10.1042/BJ20101500, 21585337.
28. Sueyoshi T, Yamamoto K, Akiyama H. Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation. Matrix Biol 2012, in press.
29. Jayachandran A, Königshoff M, Yu H, Rupniewska E, Hecker M, Klepetko W, Seeger W, Eickelberg O. SNAI transcription factors mediate epithelial-mesenchymal transition in lung fibrosis. Thorax 2009, 64:1053-1061. 10.1136/thx.2009.121798, 19850962.
30. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 2007, 13:952-961. 10.1038/nm1613, 17660828.
31. Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol 2005, 168:29-33. 2171685, 15631989.