Expression of CD4+ and IL-17, Foxp3 in non-small cell lung cancer and their correlation with microvessel density

Chinese Journal of Oncology

Volumn 34, Issue 8, 2012, Pages 596-599

  Zhang, Guo Qing ^a   Han, Feng ^a   Fang, Xin Zhi ^a   Ma, Xiao Mei ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Carcinoma, non small cell lung; CD4; Foxp3; IL 17; Neoplasm metastasis; pTNM stage; Tumor immunity

Indexed keywords

CD31 ANTIGEN; CD34 ANTIBODY; CD4 ANTIGEN; INTERLEUKIN 17; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; BLOOD VESSEL PARAMETERS; CANCER INHIBITION; CANCER INVASION; CANCER STAGING; CANCER TISSUE; CORRELATION ANALYSIS; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; METASTASIS; MICROVASCULATURE; MICROVESSEL DENSITY; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

ADULT; AGED; ANTIGENS, CD31; ANTIGENS, CD34; ANTIGENS, CD4; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-17; LUNG NEOPLASMS; MALE; MICROVESSELS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING;

EID: 84866501927     PISSN: 02533766     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0253-3766.2012.08.008     Document Type: Article

References (17)

1. Wakelee H, Kernstine K, Vokes E, et al. Cooperative group research efforts in lung cancer 2008: focus on advanced-stage non-small-cell lung cancer. Clin Lung Cancer, 2008, 9:346-351.
2. + memory T cells: functional modules for tailored immunity. Eur J Immunol, 2009, 39:2076-2082
3. Korn T, Bettelli E, Oukka M, et al. IL-17 and Th17 cells. Annu Rev Immunol, 2009, 27:485-517.
4. + T regulatory cells in humans. Hum Immunol, 2005, 66:13-20.
5. Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol, 2007, 8:277-284.
6. Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature, 2007, 445:766-770.
7. Mineo TC, Ambrogi V, Baldi A, et al. Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer. J Clin Pathol, 2004, 57:591-597.
8. Koch M, Beckhove P, Op den Winkel J, et al. Tumor infiltrating T lymphocytes in colorectal cancer: tumor-selective activation and cytotoxic activity in situ. Ann Surg, 2006, 244:986-992.
9. Numasaki M, Watanabe M, Suzuki T, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol, 2005, 175:6177-6189.
10. Kiniwa Y, Miyahara Y, Wang HY, et al. CD8+ Foxp3+ regulatory T cells mediate imunosuppression in prostate cancer. Clin Cancer Res, 2007, 13:6947-6958.
11. Fu J, Xu D, Liu Z, et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology, 2007, 132:2328-2339.
12. Tsutsui S, Matsuyama A, Yamamoto M, et al. The Akt expression correlates with the VEGF-A and-C expression as well as the microvessel and lymphatic vessel density in breast cancer. Oncol Rep, 2010, 23:621-630.
13. Gulubova M, Vlaykova T. Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer. J Gastroenterol Hepatol, 2009, 24:1265-1275.
14. Kreuter M, Kropff M, Fischaleck A, et al. Prognostic relevance of angiogenesis in stage III NSCLC receiving multimodality treatment. Eur Respir J, 2009, 33:1383-1388.