The Emerging Role of Epigenetic Modifiers Linking Cellular Metabolism and Gene Activity in Cardiac Progenitor Cells

Trends in Cardiovascular Medicine

Volumn 22, Issue 3, 2012, Pages 77-81

  Boonsanay, Verawan ^a   Kim, Johnny ^a   Braun, Thomas ^a   Zhou, Yonggang ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; ATRIAL NATRIURETIC FACTOR; DNA METHYLTRANSFERASE; HISTONE DEMETHYLASE; HISTONE H2A; HISTONE METHYLTRANSFERASE; ISOCITRATE DEHYDROGENASE 1; MYOCYTE ENHANCER FACTOR 2; POLYCOMB GROUP PROTEIN; PROTEOME; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR TBX5; TRANSCRIPTOME;

AEROBIC METABOLISM; CELL DIFFERENTIATION; CELL FATE; CELL HYPOXIA; CELL LINEAGE; CELL METABOLISM; CELL TRANSDIFFERENTIATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN CONDENSATION; CHROMATIN STRUCTURE; CONGENITAL HEART DISEASE; DECARBOXYLATION; DNA MODIFICATION; DOWNSTREAM PROCESSING; EMBRYONIC STEM CELL; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC REGULATION; GLYCOLYSIS; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; MESODERM; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; STEM CELL; TRANSCRIPTION INITIATION; WOLF HIRSCHHORN SYNDROME;

CARDIOVASCULAR SYSTEM; CHROMATIN; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; GENE EXPRESSION; HEART; HISTONES; HUMANS; MYOBLASTS, CARDIAC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84866497552     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2012.06.016     Document Type: Review

References (47)

1. Backs J., Olson E.N. Control of cardiac growth by histone acetylation/deacetylation. Circ Res 2006, 98:15-24.
2. Barth J.L., Clark C.D., Fresco V.M., et al. Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis. Dev Dyn 2010, 239:2024-2033.
3. Becker P.B., Hörz W. ATP-dependent nucleosome remodeling. Annu Rev Biochem 2002, 71:247-273.
4. Behfar A., Zingman L.V., Hodgson D.M., et al. Stem cell differentiation requires a paracrine pathway in the heart. FASEB J 2002, 16:1558-1566.
5. Bernstein B.E., Mikkelsen T.S., Xie X., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125:315-326.
6. Bracha A.L., Ramanathan A., Huang S., et al. Carbon metabolism-mediated myogenic differentiation. Nat Chem Biol 2010, 6:202-204.
7. Chang C.P., Bruneau B.G. Epigenetics and cardiovascular development. Annu Rev Physiol 2012, 74:41-68.
8. Chiang E.P., Wang Y.C., Chen W.W., Tang F.Y. Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation. J Clin Endocrinol Metab 2009, 94:1017-1025.
9. Choudhary C., Kumar C., Gnad F., et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
10. Chung S., Arrell D.K., Faustino R.S., et al. Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation. J Mol Cell Cardiol 2010, 48:725-734.
11. Delgado-Olguín P., Huang Y., Li X., et al. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet 2012, 44:343-347.
12. Donovan P.J., Gearhart J. The end of the beginning for pluripotent stem cells. Nature 2001, 414:92-97.
13. Dunwoodie S.L. The role of hypoxia in development of the mammalian embryo. Dev Cell 2009, 17:755-773.
14. Feige J.N., Auwerx J. Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol 2007, 17:292-301.
15. Gibson B.A., Kraus W.L. Small molecules, big effects: A role for chromatin-localized metabolite biosynthesis in gene regulation. Mol Cell 2011, 41:497-499.
16. Gustafsson M.V., Zheng X., Pereira T., et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005, 9:617-628.
17. He A., Ma Q., Cao J., et al. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res 2012, 110:406-415.
18. Hino S., Sakamoto A., Nagaoka K., et al. FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun 2012, 3:758.
19. Katada S., Imhof A., Sassone-Corsi P. Connecting threads: Epigenetics and metabolism. Cell 2012, 148:24-28.
20. Katoh Y., Ikura T., Hoshikawa Y., et al. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein. Mol Cell 2011, 41:554-566.
21. Ladurner A.G. Rheostat control of gene expression by metabolites. Mol Cell 2006, 24:1-11.
22. Lee S., Lee J.W., Lee S.K. UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev Cell 2012, 22:25-37.
23. Lubitz S., Glaser S., Schaft J., et al. Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2. Mol Biol Cell 2007, 18:2356-2366.
24. McGraw T.E., Mittal V. Stem cells: Metabolism regulates differentiation. Nat Chem Biol 2010, 6:176-177.
25. Molinari S., Relaix F., Lemonnier M., et al. A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300. Mol Cell Biol 2004, 24:2944-2957.
26. Nicholson T.B., Su H., Hevi S., et al. Defective heart development in hypomorphic LSD1 mice. Cell Res 2011, [Epub ahead of print].
27. Nimura K., Ura K., Shiratori H., et al. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 2009, 460:287-291.
28. Noble M., Mayer-Pröschel M., Pröschel C. Redox regulation of precursor cell function: Insights and paradoxes. Antioxid Redox Signal 2005, 7:1456-1467.
29. Okazaki K., Maltepe E. Oxygen, epigenetics and stem cell fate. Regen Med 2006, 1:71-83.
30. Olson E.N., Backs J., McKinsey T.A. Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation. Novartis Found Symp 2006, 274:3-12. Discussion 13-19, 152-155, 272-276.
31. Ozer A., Bruick R.K. Non-heme dioxygenases: Cellular sensors and regulators jelly rolled into one?. Nat Chem Biol 2007, 3:144-153.
32. Perez-Terzic C., Behfar A., Méry A., et al. Structural adaptation of the nuclear pore complex in stem cell-derived cardiomyocytes. Circ Res 2003, 92:444-452.
33. Randall V., McCue K., Roberts C., et al. Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest 2009, 119:3301-3310.
34. Sauve A.A., Wolberger C., Schramm V.L., Boeke J.D. The biochemistry of sirtuins. Annu Rev Biochem 2006, 75:435-465.
35. Schlesinger J., Schueler M., Grunert M., et al. The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet 2011, 7:e1001313.
36. Shirai M., Osugi T., Koga H., et al. The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J Clin Invest 2002, 110:177-184.
37. Stoller J.Z., Huang L., Tan C.C., et al. Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med 2010, 235:569-576.
38. Takeuchi J.K., Bruneau B.G. Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature 2009, 459:708-711.
39. Teperino R., Schoonjans K., Auwerx J. Histone methyl transferases and demethylases: Can they link metabolism and transcription?. Cell Metab 2010, 12:321-327.
40. Vallaster M., Vallaster C.D., Wu S.M. Epigenetic mechanisms in cardiac development and disease. Acta Biochim Biophys Sin (Shanghai) 2012, 44:92-102.
41. Watson J.A., Watson C.J., McCrohan A.M., et al. Generation of an epigenetic signature by chronic hypoxia in prostate cells. Hum Mol Genet 2009, 18:3594-3604.
42. Wellen K.E., Hatzivassiliou G., Sachdeva U.M., et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009, 324:1076-1080.
43. Wu H., Zhang Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev 2011, 25:2436-2452.
44. Xu W., Yang H., Liu Y., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 2011, 19:17-30.
45. Yanes O., Clark J., Wong D.M., et al. Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol 2010, 6:411-417.
46. Zhao X.D., Han X., Chew J.L., et al. Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 2007, 1:286-298.
47. Zhou Y., Kim J., Yuan X., Braun T. Epigenetic modifications of stem cells: A paradigm for the control of cardiac progenitor cells. Circ Res 2011, 109:1067-1081.