Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: A genetic, histological, and noninvasive imaging study

Wound Repair and Regeneration

Volumn 20, Issue 5, 2012, Pages 757-769

  Shih, Barbara ^a   Sultan, Muhammad J ^b   Chaudhry, Iskander H ^b   Tan, Kian T ^b   Johal, Kavan S ^b   Marstan, Arshiya ^b   Tsai, Melody ^b   Baguneid, Mohammed ^b   Bayat, Ardeshir ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COLLAGEN; HEMOGLOBIN; INHIBIN; MELANIN;

ACUTE DISEASE; ARTICLE; BIOPSY TECHNIQUE; CHRONIC WOUND; CLINICAL ARTICLE; CORRELATION ANALYSIS; GENE EXPRESSION; GENETIC ANALYSIS; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MORPHOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPECTROPHOTOMETRY; ULCER; WOUND HEALING;

ACUTE DISEASE; BIOLOGICAL MARKERS; CHRONIC DISEASE; COLLAGEN; ENGLAND; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION; HEMOGLOBINS; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBIN-BETA SUBUNITS; MALE; MELANINS; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; PROTEIN ARRAY ANALYSIS; RNA, MESSENGER; SOFT TISSUE INJURIES; THROMBOSPONDIN 1; VARICOSE ULCER; WOUND HEALING;

EID: 84866490892     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2012.00832.x     Document Type: Article

References (40)

1. Mekkes JR, Loots MAM, Van Der Wal AC, Bos JD,. Causes, investigation and treatment of leg ulceration. Br J Dermatol 2003; 148: 388-401.
2. Margolis DJ, Bilker W, Santanna J, Baumgarten M,. Venous leg ulcer: incidence and prevalence in the elderly. J Am Acad Dermatol 2002; 46: 381-386.
3. Frykberg RG,. Epidemiology of the diabetic foot: ulcerations and amputations. Adv Wound Care 1999; 12: 139-141.
4. Phillips T, Stanton B, Provan A, Lew R,. A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications. J Am Acad Dermatol 1994; 31: 49-53.
5. Posnett J, Franks PJ,. The costs of skin breakdown and ulceration in the UK. In:, Pownall M, editor. Skin breakdown: the silent epidemic. The Smith & Nephew Foundation, 2007: 6-12.
6. Stadelmann WK, Digenis AG, Tobin GR,. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 1998; 176: 26S-38S.
7. Sebastian A, Syed F, Perry D, Balamurugan V, Colthurst J, Chaudhry IH, Bayat A,. Acceleration of cutaneous healing by electrical stimulation: degenerate electrical waveform down-regulates inflammation, up-regulates angiogenesis and advances remodeling in temporal punch biopsies in a human volunteer study. Wound Repair Regen 2011; 19: 693-708.
8. Stadelmann WK, Digenis AG, Tobin GR,. Impediments to wound healing. Am J Surg 1998; 176: 39S-47S.
9. Trengove NJ, Stacey MC, Macauley S, Bennett N, Gibson J, Burslem F, Murphy G, Schultz G,. Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen 1999; 7: 442-452.
10. Schultz GS, Davidson JM, Kirsner RS, Bornstein P, Herman IM,. Dynamic reciprocity in the wound microenvironment. Wound Repair Regen 2011; 19: 134-148.
11. Mustoe T,. Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg 2004; 187: S65-S70.
12. Fivenson DP, Faria DT, Nickoloff BJ, Poverini PJ, Kunkel S, Burdick M, Strieter RM,. Chemokine and inflammatory cytokine changes during chronic wound healing. Wound Repair Regen 1997; 5: 310-322.
13. Eming SA, Krieg T, Davidson JM,. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007; 127: 514-525.
14. Ulrich D, Lichtenegger F, Unglaub F, Smeets R, Pallua N,. Effect of chronic wound exudates and MMP-2/-9 inhibitor on angiogenesis in vitro. Plast Reconstr Surg 2005; 116: 539-545.
15. Brem H, Stojadinovic O, Diegelmann RF, Entero H, Lee B, Pastar I, Golinko M, Rosenberg H, Tomic-Canic M,. Molecular markers in patients with chronic wounds to guide surgical debridement. Mol Med 2007; 13: 30-39.
16. Taverna D, Nanney LB, Pollins AC, Sindona G, Caprioli R,. Multiplexed molecular descriptors of pressure ulcers defined by imaging mass spectrometry. Wound Repair Regen 2011; 19: 734-744.
17. Moncrieff M, Otton S, Claridge E, Hall P,. Spectrophotometric intracutaneous analysis: a new technique for imaging pigmented skin lesions. Br J Dermatol 2002; 146: 448-457.
18. Tehrani H, Moncrieff M, Philp B, Dziewulski P,. Spectrophotometric intracutaneous analysis: a novel imaging technique in the assessment of acute burn depth. Ann Plast Surg 2008; 61: 437-440.
19. Bezemer R, Klijn E, Khalilzada M, Lima A, Heger M, van, Bommel J, Ince C,. Validation of near-infrared laser speckle imaging for assessing microvascular (re)perfusion. Microvasc Res 2010; 79: 139-143.
20. Matts PJ, Cotton SD,. Spectrophotometric intracutaneous analysis' (SIAscopy). In:, Paye M, Barel AO, Maibach HI, editors. Handbook of cosmetic science and technology. New York: Informa Healthcare, 2009: 275-282.
21. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J,. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5: R80.
22. Ritchie ME, Silver J, Oshlack A, Holmes M, Diyagama D, Holloway A, Smyth GK,. A comparison of background correction methods for two-colour microarrays. Bioinformatics 2007; 23: 2700-2707.
23. Smyth GK, Michaud J, Scott HS,. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 2005; 21: 2067-2075.
24. Culhane AC, Thioulouse J, Perriere G, Higgins DG,. MADE4: an R package for multivariate analysis of gene expression data. Bioinformatics 2005; 21: 2789-2790.
25. Harvey JM, Clark GM, Osborne CK, Allred DC,. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol 1999; 17: 1474-1481.
26. Burch GH, Gong Y, Liu W, Dettman RW, Curry CJ, Smith L, Miller WL, Bristow J,. Tenascin-X deficiency is associated with Ehlers-Danlos syndrome. Nat Genet 1997; 17: 104-108.
27. Arai KY, Ono M, Kudo C, Fujioka A, Okamura R, Nomura Y, Nishiyama T,. IL-1{beta} stimulates activin {beta}A mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-{kappa}B pathway, and prostaglandin E2. Endocrinology 2011; 152: 3779-3790.
28. Hubner G, Hu Q, Smola H, Werner S,. Strong induction of activin expression after injury suggests an important role of activin in wound repair. Dev Biol 1996; 173: 490-498.
29. Sulyok S, Wankell M, Alzheimer C, Werner S,. Activin: an important regulator of wound repair, fibrosis, and neuroprotection. Mol Cell Endocrinol 2004; 225: 127-132.
30. Tehrani H, Walls J, Cotton S, Sassoon E, Hall P,. Spectrophotometric intracutaneous analysis in the diagnosis of basal cell carcinoma: a pilot study. Int J Dermatol 2007; 46: 371-375.
31. Haniffa MA, Lloyd JJ, Lawrence CM,. The use of a spectrophotometric intracutaneous analysis device in the real-time diagnosis of melanoma in the setting of a melanoma screening clinic. Br J Dermatol 2007; 156: 1350-1352.
32. Moncrieff M,. Use of a spectrophotometric intracutaneous analysis device in the real-time diagnosis of melanoma. Br J Dermatol 2008; 158: 422-423; author reply 3-4.
33. Novakovic L, Cotton S, Hawk JL,. Spectrophotometric intracutaneous analysis as an early non-invasive predictor of efficacy in the phototherapy of psoriasis. Photodermatol Photoimmunol Photomed 2009; 25: 81-85.
34. Madden JW, Peacock EE, Jr,. Studies on the biology of collagen during wound healing. 3. Dynamic metabolism of scar collagen and remodeling of dermal wounds. Ann Surg 1971; 174: 511-520.
35. Haukipuro K, Melkko J, Risteli L, Kairaluoma M, Risteli J,. Synthesis of type I collagen in healing wounds in humans. Ann Surg 1991; 213: 75-80.
36. Goodson WH, 3rd, Hunt TK,. Development of a new miniature method for the study of wound healing in human subjects. J Surg Res 1982; 33: 394-401.
37. Breathnach AS,. Melanocytes in early regenerated human epidermis. J Invest Dermatol 1960; 35: 245-251.
38. Nor JE, Dipietro L, Murphy-Ullrich JE, Hynes RO, Lawler J, Polverini PJ,. Activation of latent TGF-beta1 by Thrombospondin-1 is a major component of wound repair. Oral Biosci Med 2005; 2: 153-161.
39. Streit M, Velasco P, Riccardi L, Spencer L, Brown LF, Janes L, Lange-Asschenfeldt B, Yano K, Hawighorst T, Iruela-Arispe L, Detmar M,. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. EMBO J 2000; 19: 3272-3282.
40. Shih B, McGrouther DA, Bayat A,. Identification of novel keloid biomarkers through profiling of tissue biopsies versus cell cultures in keloid margin specimens compared to adjacent normal skin. Eplasty 2010; 10: e24.