메뉴 건너뛰기




Volumn 84, Issue 1, 2012, Pages 93-100

Tyrosine kinase inhibitors for elderly chronic myeloid leukemia patients: A systematic review of efficacy and safety data

Author keywords

Chronic myeloid leukemia; Elderly; Imatinib; Second generation TKIs

Indexed keywords

ALPHA INTERFERON; BUSULFAN; CYTARABINE; DASATINIB; GAMMA INTERFERON; HYDROXYUREA; IMATINIB; INTERFERON; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT ALPHA INTERFERON AD;

EID: 84866490652     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2012.01.001     Document Type: Review
Times cited : (30)

References (25)
  • 1
    • 0141528828 scopus 로고    scopus 로고
    • Chronic myeloid leukemia - advances in biology and new approaches to treatment
    • Goldman J.M., Melo J.V. Chronic myeloid leukemia - advances in biology and new approaches to treatment. N Engl J Med 2003, 349:1451-1464.
    • (2003) N Engl J Med , vol.349 , pp. 1451-1464
    • Goldman, J.M.1    Melo, J.V.2
  • 2
    • 34447646300 scopus 로고    scopus 로고
    • Chronic myeloid leukaemia
    • European LeukemiaNet
    • Hehlmann R., Hochhaus A., Baccarani M. Chronic myeloid leukaemia. Lancet 2007, 370:342-350. European LeukemiaNet.
    • (2007) Lancet , vol.370 , pp. 342-350
    • Hehlmann, R.1    Hochhaus, A.2    Baccarani, M.3
  • 3
    • 33749525672 scopus 로고    scopus 로고
    • The age incidence of chronic myeloid leukemia can be explained by a one-mutation model
    • Michor F., Iwasa Y., Nowak M.A. The age incidence of chronic myeloid leukemia can be explained by a one-mutation model. Proc Natl Acad Sci U S A 2006, 103:14931-14934.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14931-14934
    • Michor, F.1    Iwasa, Y.2    Nowak, M.A.3
  • 4
    • 62549108246 scopus 로고    scopus 로고
    • Clinical trials underestimate the age of chronic myeloid leukemia (CML) patients. Incidence and median age of Ph/BCR-ABL-positive CML and other chronic myeloproliferative disorders in a representative area in Germany
    • Rohrbacher M., Berger U., Hochhaus A., et al. Clinical trials underestimate the age of chronic myeloid leukemia (CML) patients. Incidence and median age of Ph/BCR-ABL-positive CML and other chronic myeloproliferative disorders in a representative area in Germany. Leukemia 2009, 23:602-604.
    • (2009) Leukemia , vol.23 , pp. 602-604
    • Rohrbacher, M.1    Berger, U.2    Hochhaus, A.3
  • 5
    • 4544317577 scopus 로고    scopus 로고
    • The Scotland Leukemia Registry audit of incidence, diagnosis and clinical management of new patients with chronic myeloid leukemia in 1999 and 2000
    • Harrison S.J., Johnson P.R.E., Holyoake T.L. The Scotland Leukemia Registry audit of incidence, diagnosis and clinical management of new patients with chronic myeloid leukemia in 1999 and 2000. Scott Med J 2004, 49:87-90.
    • (2004) Scott Med J , vol.49 , pp. 87-90
    • Harrison, S.J.1    Johnson, P.R.E.2    Holyoake, T.L.3
  • 6
    • 20844441765 scopus 로고    scopus 로고
    • Gender aspects in chronic myeloid leukemia: long-term results from randomized studies
    • Berger U., Maywald O., Pfirmann M., et al. Gender aspects in chronic myeloid leukemia: long-term results from randomized studies. Leukemia 2005, 19:984-989.
    • (2005) Leukemia , vol.19 , pp. 984-989
    • Berger, U.1    Maywald, O.2    Pfirmann, M.3
  • 7
    • 79955660925 scopus 로고    scopus 로고
    • Targeted ant-cancer therapy in the elderly
    • Gonsalves W., Ganti A.K. Targeted ant-cancer therapy in the elderly. Crit Rev Oncol Hematol 2011, 78:227-242.
    • (2011) Crit Rev Oncol Hematol , vol.78 , pp. 227-242
    • Gonsalves, W.1    Ganti, A.K.2
  • 8
    • 0023231124 scopus 로고
    • Old age is a sign of poor prognosis in patients with chronic myelogenous leukemia
    • Kantarjian H., Keating M., McCredie K., et al. Old age is a sign of poor prognosis in patients with chronic myelogenous leukemia. Southern Med J 1988, 80:1233-1235.
    • (1988) Southern Med J , vol.80 , pp. 1233-1235
    • Kantarjian, H.1    Keating, M.2    McCredie, K.3
  • 9
    • 0029664772 scopus 로고    scopus 로고
    • Result of interferon-alpha therapy in patients with chronic myelogenous leukemia 60 years of age and older
    • Cortes J., Kantarjian H., O'Brien S., et al. Result of interferon-alpha therapy in patients with chronic myelogenous leukemia 60 years of age and older. Am J Med 1996, 100:452-455.
    • (1996) Am J Med , vol.100 , pp. 452-455
    • Cortes, J.1    Kantarjian, H.2    O'Brien, S.3
  • 10
    • 0032191474 scopus 로고    scopus 로고
    • Interferon-alpha for the treatment of elderly patients with chronic myeloid leukemia
    • Hilbe W., Apfelbeck U., Fridrik M., et al. Interferon-alpha for the treatment of elderly patients with chronic myeloid leukemia. Leuk Res 1998, 22:881-886.
    • (1998) Leuk Res , vol.22 , pp. 881-886
    • Hilbe, W.1    Apfelbeck, U.2    Fridrik, M.3
  • 11
    • 0141502204 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in the elderly: long-term results from randomized trials with interferon alpha
    • Berger U., Engelich G., Maywald O., et al. Chronic myeloid leukemia in the elderly: long-term results from randomized trials with interferon alpha. Leukemia 2003, 17:1820-1826.
    • (2003) Leukemia , vol.17 , pp. 1820-1826
    • Berger, U.1    Engelich, G.2    Maywald, O.3
  • 12
    • 0041917185 scopus 로고    scopus 로고
    • Effects of age on prognosis with imatinib mesylate therapy for patients with Philadelphia chromosome-positive chronic myelogenous leukemia
    • Cortes J., Talpaz M., O'Brien S., et al. Effects of age on prognosis with imatinib mesylate therapy for patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Cancer 2003, 98:1105-1113.
    • (2003) Cancer , vol.98 , pp. 1105-1113
    • Cortes, J.1    Talpaz, M.2    O'Brien, S.3
  • 13
    • 19944432935 scopus 로고    scopus 로고
    • Elderly patients with Ph+ chronic myelogenous leukemia (CML): results off imatinib mesylate treatment
    • Latagliata R., Breccia M., Carmosino I., et al. Elderly patients with Ph+ chronic myelogenous leukemia (CML): results off imatinib mesylate treatment. Leuk Res 2005, 29:287-291.
    • (2005) Leuk Res , vol.29 , pp. 287-291
    • Latagliata, R.1    Breccia, M.2    Carmosino, I.3
  • 14
    • 33846935242 scopus 로고    scopus 로고
    • Impact off age on the outcome off patients with chronic myeloid leukemia in late chronic phase: results off a phase II study off the GIMEMA CML Working Party
    • Rosti G., Iacobucci I., Bassi S., et al. Impact off age on the outcome off patients with chronic myeloid leukemia in late chronic phase: results off a phase II study off the GIMEMA CML Working Party. Haematologica 2007, 92:101-105.
    • (2007) Haematologica , vol.92 , pp. 101-105
    • Rosti, G.1    Iacobucci, I.2    Bassi, S.3
  • 15
    • 77957021650 scopus 로고    scopus 로고
    • "Real-life" results of front-line treatment with imatinib in older patients (>65 years) with newly diagnosed chronic myelogenous leukemia
    • Latagliata R., Breccia M., Carmosino I., et al. "Real-life" results of front-line treatment with imatinib in older patients (>65 years) with newly diagnosed chronic myelogenous leukemia. Leuk Res 2010, 34:1472-1475.
    • (2010) Leuk Res , vol.34 , pp. 1472-1475
    • Latagliata, R.1    Breccia, M.2    Carmosino, I.3
  • 16
    • 77951113234 scopus 로고    scopus 로고
    • Therapy with imatinib in elderly CML patients (>65 years) is well tolerated but cytogenetic and molecular remissions seem to be achieved later compared to younger patients
    • abst 0625
    • Pletsch N., Lauseker M., Saussele S., et al. Therapy with imatinib in elderly CML patients (>65 years) is well tolerated but cytogenetic and molecular remissions seem to be achieved later compared to younger patients. Haematologica 2009, 94:253. abst 0625.
    • (2009) Haematologica , vol.94 , pp. 253
    • Pletsch, N.1    Lauseker, M.2    Saussele, S.3
  • 17
    • 80051469954 scopus 로고    scopus 로고
    • Evaluation of tolerability and efficacy on imatinib mesylate in elderly patients with chronic phase CML: ELDERGLI study
    • Sanchez-Gujio F.M., Duran S., Galende J., et al. Evaluation of tolerability and efficacy on imatinib mesylate in elderly patients with chronic phase CML: ELDERGLI study. Leuk Res 2011, 35:1184-1187.
    • (2011) Leuk Res , vol.35 , pp. 1184-1187
    • Sanchez-Gujio, F.M.1    Duran, S.2    Galende, J.3
  • 18
    • 79957588158 scopus 로고    scopus 로고
    • Frontline imatinib treatment off chronic myeloid leukemia: no impact off age on outcome, a survey by the GIMEMA CML Working Party
    • Gugliotta G., Castagnetti F., Palandri F., et al. Frontline imatinib treatment off chronic myeloid leukemia: no impact off age on outcome, a survey by the GIMEMA CML Working Party. Blood 2011, 117:5591-5599.
    • (2011) Blood , vol.117 , pp. 5591-5599
    • Gugliotta, G.1    Castagnetti, F.2    Palandri, F.3
  • 19
    • 79960685618 scopus 로고    scopus 로고
    • Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score
    • Hasford J., Baccarani M., Hoffmann V., et al. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood 2011, 118:686-692.
    • (2011) Blood , vol.118 , pp. 686-692
    • Hasford, J.1    Baccarani, M.2    Hoffmann, V.3
  • 20
    • 68249159552 scopus 로고    scopus 로고
    • Nilotinib in elderly chronic myeloid leukemia patients in chronic phase (CML-CP) with imatinib resistance or intolerance: efficacy and safety analysis
    • Lipton J.H., le Coutre P.D., Wang J., et al. Nilotinib in elderly chronic myeloid leukemia patients in chronic phase (CML-CP) with imatinib resistance or intolerance: efficacy and safety analysis. Blood 2008, 112:3233.
    • (2008) Blood , vol.112 , pp. 3233
    • Lipton, J.H.1    le Coutre, P.D.2    Wang, J.3
  • 21
    • 78649289294 scopus 로고    scopus 로고
    • Efficacy and safety off nilotinib in elderly patients with imatinib-resistant or intolerant chronic myeloid leukemia (CML) in chronic phase 8CP: a sub-analysis off the ENACT (Expanding nilotinib access in clinical trials) study
    • le Coutre P.D., Turkina A., Kim D.W., et al. Efficacy and safety off nilotinib in elderly patients with imatinib-resistant or intolerant chronic myeloid leukemia (CML) in chronic phase 8CP: a sub-analysis off the ENACT (Expanding nilotinib access in clinical trials) study. Blood 2009, 114:3286.
    • (2009) Blood , vol.114 , pp. 3286
    • le Coutre, P.D.1    Turkina, A.2    Kim, D.W.3
  • 22
    • 80051471275 scopus 로고    scopus 로고
    • Dasatinib is safe and effective in unselected chronic myeloid leukemia elderly patients resistant/intolerant to imatinib
    • Latagliata R., Breccia M., Castagnetti F., et al. Dasatinib is safe and effective in unselected chronic myeloid leukemia elderly patients resistant/intolerant to imatinib. Leuk Res 2011, 35:1164-1169.
    • (2011) Leuk Res , vol.35 , pp. 1164-1169
    • Latagliata, R.1    Breccia, M.2    Castagnetti, F.3
  • 23
    • 80053634632 scopus 로고    scopus 로고
    • Charlson comorbidity index and adult comorbidity evaluation-27 might predict compliance and development of pleural effusions in elderly chronic myeloid leukemia patients treated with dasatinib after resistance/intolerance to imatinib
    • Breccia M., Latagliata R., Stagno F., et al. Charlson comorbidity index and adult comorbidity evaluation-27 might predict compliance and development of pleural effusions in elderly chronic myeloid leukemia patients treated with dasatinib after resistance/intolerance to imatinib. Haematologica 2011, 96:1457-1461.
    • (2011) Haematologica , vol.96 , pp. 1457-1461
    • Breccia, M.1    Latagliata, R.2    Stagno, F.3
  • 24
    • 80053640845 scopus 로고    scopus 로고
    • Safety and efficacy of dasatinib vs imatinib by baseline comorbidity in patients with chronic myeloid leukemia in chronic phase (CML-CP): analysis of the DASISION trial
    • abstr 3421
    • Khoury H.J., Cortes J.E., Kantarjian H., et al. Safety and efficacy of dasatinib vs imatinib by baseline comorbidity in patients with chronic myeloid leukemia in chronic phase (CML-CP): analysis of the DASISION trial. Blood 2010, 116. abstr 3421.
    • (2010) Blood , vol.116
    • Khoury, H.J.1    Cortes, J.E.2    Kantarjian, H.3
  • 25
    • 84871459751 scopus 로고    scopus 로고
    • Nilotinib shows safety and efficacy in older patients (<65 years) with newly diagnosed chronic myeloid leukemia in chronic phase comparable with that in younger patients with chronic myeloid leukemia in chronic phase: results from ENESTnd
    • abstr 3768
    • Larson R.A., Bunworasate U., Turkina A.G., et al. Nilotinib shows safety and efficacy in older patients (<65 years) with newly diagnosed chronic myeloid leukemia in chronic phase comparable with that in younger patients with chronic myeloid leukemia in chronic phase: results from ENESTnd. Blood 2011, abstr 3768.
    • (2011) Blood
    • Larson, R.A.1    Bunworasate, U.2    Turkina, A.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.