Pyruvate kinase activity and 7delta;-aminolevulinic acid dehydratase activity as biomarkers of toxicity in workers exposed to lead

Archives of Environmental Contamination and Toxicology

Volumn 63, Issue 3, 2012, Pages 453-460

  Feksa, Luciane Rosa ^a,b   Oliveira, Evandro ^a   Trombini, Thereza ^a   Luchese, Mateus ^a   Bisi, Saiuri ^a   Linden, Rafael ^a   Berlese, Daiane Bolzan ^a   Rojas, Denise Bertin ^b   Andrade, Rodrigo Binkowski ^b   Schuck, Patricia Fernanda ^b,c   Lacerda, Larissa Machado ^a   Wajner, Moacir ^b   Wannmacher, Clovis Milton Duval ^b   Emanuelli, Tatiana ^d  

^a UNIVERSIDADE FEEVALE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; HEMOGLOBIN; LEAD; PORPHOBILINOGEN SYNTHASE; PYRUVATE KINASE;

BIOMARKER; BIOMONITORING; CELL ORGANELLE; CONCENTRATION (COMPOSITION); DOSE-RESPONSE RELATIONSHIP; ENZYME ACTIVITY; HOMEOSTASIS; INHIBITION; ION EXCHANGE; LEAD; MANUFACTURING; METABOLISM; ORGANIC ACID; PATHOGENICITY; POLLUTION EXPOSURE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE COUNT; FEMALE; HEMATOCRIT; HUMAN; HUMAN CELL; LEAD BLOOD LEVEL; LEAD POISONING; LEUKOCYTE COUNT; MALE; OCCUPATIONAL HAZARD; PRIORITY JOURNAL; WORKER;

ADULT; BIOLOGICAL MARKERS; ERYTHROCYTES; GLUTATHIONE TRANSFERASE; HAZARDOUS SUBSTANCES; HUMANS; LEAD; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PORPHOBILINOGEN SYNTHASE; PYRUVATE KINASE; YOUNG ADULT;

EID: 84866490056     PISSN: 00904341     EISSN: 14320703     Source Type: Journal    
DOI: 10.1007/s00244-012-9786-z     Document Type: Article

References (58)

1. Agency for Toxic Substances and Disease Registry: Toxicological Profile for Lead (2007) United States Department of Heath and Human Services, Public Health Service, ATSDR
2. Armstrong JS, Jones DP (2002) Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J 16(10):1263-1265
3. Berlin A, Schaller KH (1974) European standardized method for the determination of delta-aminolevulinic acid dehydratase activity in blood. Z Klin Chem Klin Biochem 12:389-390
4. Bernard A, Lauwerys R (1987) Metal-induced alterations of deltaaminolevulinic acid dehydratase. Ann N Y Acad Sci 514:41-47 (Pubitemid 18097955)
5. Berry E, Toms NJ (2006) Pyruvate and oxaloacetate limit zincinduced oxidative HT-22 neuronal cell injury. Neurotoxicology 27(6):1043-1051 (Pubitemid 44838959)
6. Bianchi P, Zanella A (2000) Hematologically important mutations: Red cell pyruvate kinase (third update). Blood Cells Mol Dis 26:47-53 (Pubitemid 30331771)
7. Brito JA, McNeill FE, Webber CE, Wells S, Richard N, Carvalho ML et al (2002) Evaluation of a novel structural model to describe the endogenous release of lead from bone. J Environ Monit 4:194-201 (Pubitemid 34407388)
8. Browne RW, Armstrong D (1998) Reduced glutathione and glutathione disulfide. Methods Mol Biol 108:347-352
9. Calderón-Salinas JV, Hernández-Luna C, Valdez-Anaya B, Maldonado- Vega M, López-Miranda A (1996a) Evolution of lead toxicity in a population of children. Hum Exp Toxicol 15: 376-382 (Pubitemid 26154793)
10. Calderón-Salinas JV, Valdez-Anaya B, Mazúniga-Charles Albores- Medina A (1996b) Lead exposure in a population of Mexican children. Hum Exp Toxicol 15(4):305-311
11. Calderón-Salinas JV, Quintanar-Escorza MA, Hernández-Luna CE, González- Martínez MT (1999a) Effect of lead on the calcium transport in human erythrocyte. Hum Exp Toxicol 18(3): 146-153 (Pubitemid 29134904)
12. Calderón-Salinas JV, Quintanar-Escorza MA, González- Martínez MT, Hernández-Luna CE (1999b) Lead and calcium transport in human erythrocyte. Hum Exp Toxicol 18(5):327-332 (Pubitemid 29253645)
13. Courtois E, Marques M, Barrientos A (2003) Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase- 2. J Am Soc Nephrol 14:1464-1470 (Pubitemid 36687047)
14. Das UN (2006) Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule. Int Med J Exp Clin Res 12:79-84
15. Dusinska M, Collins AR (2008) The comet assay in human biomonitoring: Gene-environment interactions. Mutagenesis 23:191-205
16. Ekong EB, Jaar BG, Weaver VM (2006) Lead-related nephrotoxicity: A review of epidemiologic evidence. Kidney Int 70: 2074-2084 (Pubitemid 44871369)
17. Ercal N, Gurer-Orhan H, Aykin-Burns N (2011) Toxic metals and oxidative stress. Part 1. Mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 1:529-539
18. Farant JP, Wigfield DC (1982) Biomonitoring lead exposure with delta-aminolevulinate dehydratase (ALA-D) activity ratios. Int Arch Occup Environ Health 51:15-24 (Pubitemid 13198360)
19. Garza A, Vega R, Soto E (2006) Cellular mechanisms of lead neurotoxicity. Med Sci Monit 12(3):57-65
20. Gilbert HF (1984) Redox control of enzyme activities by thiol/disulfide exchange. Methods Enzymol 107:330-351 (Pubitemid 14053814)
21. Goering PL (1993) Lead-protein interactions as a basis for lead toxicity. Neurotoxicology 14(2-3):45-60 (Pubitemid 23292790)
22. Greenwood NN, Earnshaw A (1997) Chemistry of the elements, 2nd edn. Butterworth-Heinemann, London
23. Gurer H, Ercal N (2000) Can antioxidants be beneficial in the treatment of lead poisoning? Free Radic Biol Med 29:927-945
24. Gurer H, Neal R, Yang P, Oztezcan S, Ercal N (1999) Captropril as an antioxidant in lead-exposed Fischer 344 rats. Hum Exp Toxicol 18:27-32 (Pubitemid 29054469)
25. Gurer-Ohrnan H, Sabir HU, Ozgünes H (2004) Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers. Toxicology 195(2-3):147-154 (Pubitemid 38125115)
26. Hall ER, Cottam GL (1978) Isoenzymes of pyruvate kinase in vertebrates: Their physical, chemical, kinetic and immunological properties. Int J Biochem 9:785-793
27. Huang M, Krepkiy D, Hu W, Petering DH (2004) Zn-, Cd-, and Pbtranscription factor IIIA: Properties, DNA binding, and comparison with TFIIIA finger 3 metal complexes. J Inorg Biochem 98:775-785 (Pubitemid 38595280)
28. Korsrud GO, Meldrum JB (1988) Effect of diet on response in rats to lead acetate given orally or in the drinking water. Biol Trace Elem Res 17:167-173 (Pubitemid 18267825)
29. Lauwerys R, Buchet JP, Roels HA, Materne DO (1974) Relationship between urinary delta-aminolevulinic acid excretion and the inhibition or read cell delta-aminolevulinate dehydratase by lead. Clin Toxicol 7:383-388
30. Lawton LJ, Donaldson WE (1991) Lead-induced tissue fatty acid alterations and lipid peroxidation. Biol Trace Elem Res 28:83-97
31. Leech NL, Barrett KC, Morgan GA (2005) SPSS for intermediate statistics. Use and interpretation, 2nd edn. Lawrence Erlbaum Associates, London
32. Leong SF, Lai JCK, Lim L, Clark JB (1981) Energy-metabolising enzymes in brain regions of adult and aging rats. J Neurochem 37:1548-1556 (Pubitemid 12219001)
33. Lepper TW, Evandro Oliveira E, Koch GDW, Berlese DB, Feksa LR (2010) Lead inhibits in vitro creatine kinase and pyruvate kinase activity in brain cortex of rats. Toxicol in Vitro 24:1045-1051
34. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
35. Meister A (1994) Glutathione, ascorbate, and cellular protection. Cancer Res 54:1969-1975
36. Menke A, Muntner P, Batuman P, Silbergeld EK, Guallar E (2006) Blood lead below 0.48 lmol/L (100 lg L-1) and mortality among US adults. Circulation 114:1388-1394 (Pubitemid 44454558)
37. Meredith PA, Moore MR, Campbell BC, Thompson GG, Goldberg A (1978) Delta-aminolevulinic acid metabolism in normal and lead-exposed humans. Toxicology 9:1-9 (Pubitemid 8307313)
38. Muntener P, He J, Vupputuri S, Coresh J, Batuman V (2003) Blood lead and chronic kidney disease in the general United States population: Results from NHANES III. Kidney Int 63:1044-1050 (Pubitemid 36315583)
39. Nash D, Magder L, Lustberg M, Sherwin RW, Rubin RJ, Kaufmann RB, Silbergeld EK (2003) Blood lead, blood pressure, and hypertension in perimenopausal and postmenopausal women. JAMA 289(12):1523-1532 (Pubitemid 37430291)
40. Navarro-Moreno LG, Quintanar-Escorza MA, González S, Mondrago ́n R, Cerbón-Solorzáno J, Valdés J et al (2009) Effects of lead intoxication on intercellular junctions and biochemical alterations of the renal proximal tubule cells. Toxicol In Vitro 23:1298-1304
41. Noguchi T, Yamada K, Inoue H, Matsuda T, Tanaka T (1987) The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J Biol Chem 262:14366-14371
42. Nunes-Tavares N, Valverde RHF, Araújo GMN, Hassón-Voloch A (2005) Toxicity induced by Hg2? on choline acetyltransferase activity from E. electricus (L.) electrocytes: The protective effect of 2,3 dimercapto-propanol (BAL). Med Sci Monit 11(4):100-105
43. Occupational Safety and Health Administration (2008) Employee standard summary - 1910.1025 App B [displayed 6 January 2008]. Available at: Http://www.osha.gov/Publications/OSHA 3348-metal-scrap-recycling.pdf
44. Olewińska E, Kasperczyk A, Kapka L, Kozłowska A, Pawlas N, Dobrakowski M et al (2010) Level of DNA damage in leadexposed workers. Ann Agric Environ Med 17:231-236
45. Onalaja AO, Claudio L (2000) Genetic susceptibility to lead poisoning. Environ Health Perspect 108:23-28 (Pubitemid 30168693)
46. Quintanar-Escorza MA, González-Martínez MT, Navarro L, Maldonado M, Arévalo B, Calderón-Salinas JV (2007) Intracellular free calcium concentration and calcium transport in human erythrocyte of lead-exposed workers. Toxicol Appl Pharmacol 220:1-8 (Pubitemid 46437256)
47. Reed DJ (1990) Glutathione: Toxicological implications. Annu Rev Pharmacol Toxicol 30:603-631
48. Rendón-Ramírez A, Cerbón-Solórzano J, Maldonado-Vega M, Quintanar- Escorza MA, Calderón-Salinas JV (2007) Vitamin-E reduces the oxidative damage on delta-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes. Toxicol in Vitro 21(6):1121-1126 (Pubitemid 47243650)
49. Ribarov SR, Benov LC (1981) Relationship between the hemolytic action of heavy metals and lipid peroxidation. Biochim Biophys Acta 640:721-726 (Pubitemid 11134807)
50. Sakai T (2000) Biomarkers of lead exposure. Ind Health 38:127-142 (Pubitemid 30256979)
51. Selander S, Cramer K (1970) Interrelationship between lead in blood, lead in urine and ALA in urine during lead worse. Br J Ind Med 27:28-39
52. Sithisarankul P, Schwartz BS, Lee BK, Strickland PT (1998) Urinary 5-aminolevuinic acid (ALA) adjusted by creatinine a surrogate for plasma ALA. J Occup Environ Med 40:901-908
53. Todd AC, Wetmur JG, Moline JM, Godbold JH, Levin SM, Landrigan PJ (1996) Unraveling the chronic toxicity of lead: An essential priority for environmental health. Environ Health Perspect 104:141-146 (Pubitemid 26123099)
54. Valle BL, Ulmer DD (1972) Biochemical effects of mercury, cadmium and lead. Annu Rev Biochem 41:91-128
55. van Bemmel DM, Boffetta P, Liao LM, Berndt SI, Menashe I, Yeager M et al (2011) Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead. PLoS One 6(7):1-7
56. Warren MJ, Cooper JB, Wood SP, Shoolingin JPM (1998) Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase. Trends Biochem Sci 23:217-221 (Pubitemid 28302619)
57. World Health Organization (1995) International Programme on Chemical Safety Environmental Health criteria 165: Inorganic lead. WHO, Geneva
58. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health. J Nutr 134:489-492 (Pubitemid 38298485)