Urinary 5-aminolevulinic acid (ALA) adjusted by creatinine: A surrogate for plasma ALA?

Journal of Occupational and Environmental Medicine

Volumn 40, Issue 10, 1998, Pages 901-906

  Sithisarankul, Pornchai ^a   Schwartz, Brian S ^a   Lee, Byung Kook ^b   Strickland, Paul T ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b Soonchunhyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; BIOLOGICAL MARKER; CREATININE; LEAD; PORPHOBILINOGEN SYNTHASE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; ENZYME ACTIVITY; ENZYME SUBSTRATE; HEME SYNTHESIS; HUMAN; LEAD BLOOD LEVEL; LEAD POISONING; MAJOR CLINICAL STUDY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; URINARY EXCRETION;

ADULT; AMINOLEVULINIC ACID; CREATININE; HUMANS; LEAD; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PORPHOBILINOGEN SYNTHASE;

EID: 0031725894     PISSN: 10762752     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043764-199810000-00011     Document Type: Article

References (19)

1. Boeniger MF, Lowry LK, Rosenberg J. Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustment: a review. Am Ind Hyg Assoc J. 1993;54:615-627.
2. Diamond GL. In: Clarkson TW, Friberg L, Nordberg GF, Sager PR, eds. Biological Monitoring of Toxic Metals. Rochester Series on Environmental Toxicity. 1988:515-525.
3. Hudák A, Kiss G. Improved method for the adjustment of urinary delta-aminolevulinic acid concentration. Am J Ind Med. 1991;19:59-65.
4. Hudák A, Náray M, Süveges É. Clinical relevance of urinary delta-aminolevulinic acid/logarithm of creatinine ratio in screening for occupational lead exposure. Am J Ind Med. 1992;21:673-680.
5. Cameron JS. Renal function testing. In: Cameron S, Davison AM, Grünfeld J-P, Kerr D, Ritz E, eds. Oxford Textbook of Clinical Nephrology. Oxford, UK: Oxford University Press; 1992:24-49.
6. Schuster VL, Seldin DW. Renal clearance. In: Seldin DW, Giebisch G, eds. The Kidney Physiology and Pathophysiology, 2nd ed. New York: Raven Press; 1992:943-952.
7. Kappas A, Sassa S, Galbraith RA, Nordmann Y. The porphyrias. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease, 6th ed. New York: McGraw-Hill; 1995:2103-2159.
8. Morita Y, Araki S, Sakai T, Araki T, Masuyama Y. Determination of delta-aminolevulinic acid in plasma using high-performance liquid chromatography: a sensitive indicator of lead effects. Ind Health. 1994;32:85-96.
9. Araki S, Murata K, Yokoyama K, et al. Orcadian rhythms in the urinary excretion of metals and organic substances in healthy men. Arch Environ Health. 1983; 38:360-366.
10. Gorchein A, Webber R. δ-Aminolaevulinic acid in plasma, cerebrospinal fluid, saliva and erythrocytes: studies in normal, uraemic and porphyric subjects. Clin Sci. 1987;72:103-112.
11. Aono H, Araki S. Circadian rhythms in the urinary excretion of heavy metals and organic substances in metal workers in relation to renal excretory mechanism: profile analysis. Int Arch Occup Environ Health. 1988;60:1-6.
12. Tomokuni K, Ichiba M, Fujishiro K. Interrelation between urinary δ-aminolevulinic acid (ALA), serum ALA, and blood lead in workers exposed to lead. Ind Health. 1993;31:51-57.
13. Sithisarankul P, Schwartz BS, Lee BK, Kelsey KT, Strickland PT. Aminolevulinic acid dehydratase genotype mediates plasma levels of the neurotoxin, 5-aminolevulinic acid, in lead-exposed workers. Am J Ind Med. 1997;32:15-20.
14. Schwartz BS, Lee BK, Stewart W, Ahn KD, Springer K, Kelsey KT. Associations of δ-aminolevulinic acid dehydratase genotype with plant, exposure duration, and blood and zinc protoporphyrin levels in Korean lead workers. Am J Epidemiol. 1995;142:738-745.
15. Tomokuni K, Ichiba M, Hirai Y. HPLC micro-method for determining δ-aminolevulinic acid in plasma. Clin Chem. 1993;39:169-170.
16. Pruszkowska E, Carnrick GR, Slavin W. Blood lead determination with the platform furnace technique. Atomic Spect. 1983;4:59-61.
17. Burtis CA, Ashwood ER. Teitz Textbook of Clinical Chemistry. Philadelphia: WB Saunders; 1994:1221-1222, 2020-2021, 2096-2097.
18. Létourneau GG, Plante R, Weber JP. Blood lead and maximal urinary excretion of delta-aminolevulinic acid. Am Ind Hyg Assoc J. 1988;49:342-345.
19. Sakai T, Morita Y. δ-Aminolevulinic acid in plasma or whole blood as a sensitive indicator or lead effects, and its relation to the other heme-related parameters. Int Arch Occup Environ Health. 1996;68:126-132.