Multiparametric immunotoxicity screening in mice during early drug development

Toxicology Letters

Volumn 214, Issue 2, 2012, Pages 200-208

  Auli M ^a   Domenech A ^a   Andres A ^a   Orta, M ^a   Salva M ^a   Descotes, J ^b   Prats, N ^a  

^a Almirall Prodesfarma S A   (Spain)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Early screening; Immunotoxicity; KLH; Mice; Pharmaceuticals; TDAR

Indexed keywords

CHLORPROMAZINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DEXAMETHASONE; PREDNISOLONE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CROSS REACTION; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; IMMUNOTOXICITY; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MOUSE; NONHUMAN; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; RETICULOCYTE COUNT; SPLEEN WEIGHT; THYMUS; WEIGHT GAIN;

ANIMALS; BLOOD CELL COUNT; BODY WEIGHT; DRUG EVALUATION, PRECLINICAL; HEMOCYANIN; IMMUNOGLOBULIN M; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; LYMPHOID TISSUE; MALE; MICE; ORGAN SIZE; TOXICITY TESTS;

MUS;

EID: 84866479621     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.08.020     Document Type: Article

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