Pre-explant stability of unloading-promoted cardiac improvement predicts outcome after weaning from ventricular assist devices

Circulation

Volumn 126, Issue 11 SUPPL.1, 2012, Pages

  Dandel, Michael ^a   Weng, Yuguo ^a   Siniawski, Henryk ^a   Potapov, Evgenij ^a   Krabatsch, Thomas ^a   Lehmkuhl, Hans B ^a   Drews, Thorsten ^a   Knosalla, Christoph ^a   Hetzer, Roland ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

cardiomyopathy; heart failure; myocardial recovery; risk factors; survival; ventricular assist devices

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CARDIOMYOPATHY; CARDIOVASCULAR PARAMETERS; ECHOCARDIOGRAPHY; EXPLANT; FEMALE; HEART ASSIST DEVICE; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE SIZE; HEART LEFT VENTRICLE WALL MOTION; HEART VENTRICLE HYPERTROPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; SYSTOLE;

ADOLESCENT; ADULT; AGED; CARDIOVASCULAR AGENTS; COMBINED MODALITY THERAPY; DEVICE REMOVAL; FEMALE; HEART FAILURE; HEART-ASSIST DEVICES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; ORGAN SIZE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECOVERY OF FUNCTION; RECURRENCE; RETROSPECTIVE STUDIES; STROKE VOLUME; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; YOUNG ADULT;

EID: 84866465255     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.084640     Document Type: Article

References (24)

1. Torre-Amione G, Loebe M, Myocardial recovery following prolonged mechanical support. In: Frazier OH, Kirklin JK, eds. ISHLT Monograph Series. Mechanical Circulatory Support, Vol 1. New York: Elsevier;2006: 155-169.
2. Frazier OH, Benedect CR, Radovancevic B, Bick RJ, Capek P, Springer WE, Macris MP, Delgado R, Buja LM. Improved left ventricular function after chronic left ventricular unloading. Ann Thorac Surg. 1996;62: 675-682.
3. Hall JL, Fermin DR, Birks EJ, Barton PJ, Slaughter M, Eckman P, Baba HA, Wohlschlaeger J, Miller LW. Clinical, molecular, and genomic changes in response to a left ventricular assist device. J Am Coll Cardiol. 2011;57:641-652.
4. Akhter SA, D'Souza KM, Malhotra R, Staron ML, Valeroso TB, Fedson SE, Anderson AS, Raman J, Jeevanandam V. Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support. J Heart Lung Transplant. 2010;29: 603-609.
5. Saito S, Matsumiya G, Sakaguchi T, Miyagawa S, Yamauchi T, Kuratani T, Sawa Y. Cardiac fibrosis and cellular hypertrophy decrease the degree of reverse remodeling and improvement in cardiac function during left ventricular assist. J Heart Lung Transplant. 2010;29:672-679.
6. Ogletree ML, Sweet WE, Talerico C, Klecka ME, Young JB, Smedira NG, Starling RC, Moravec CS. Duration of left ventricular assist device support: effects on abnormal calcium cycling and functional recovery in the failing human heart. J Heart Lung Transplant. 2010;29:554-561.
7. Maybaum S, Mancini D, Xydas S, Starling RC, Aaronson K, Pagani FD, Miller LW, Margulies K, McRee S, Frazier OH. Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group. Circulation. 2007;15:2497-2505.
8. Ambardekar AV, Walker JS, Walker LA. et al. Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail. 2011; 4:425-432.
9. Ferrar DJ, Holmann WR, McBride LR, Kormos RL, Icenogle TB, Hendri PJ, Moore CH, Loisance DY, El-Banayosy A, Frazier H. Long-term follow up of Thoratec ventricular assist device bridge-to-recovery patients successfully removed from support after recovery of ventricular function. J Heart Lung Transplant. 2002;21:516-521.
10. Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J, Winowich S, McNamara DM. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation. 2005;112:I-32-I-36.
11. Müller J, Wallukat G, Weng Y, Dandel M, Spiegelsberger S, Semrau S, Brandes K, Bieda H, Hummel M, Loebe M, Meyer R, Hetzer R. Weaning from mechanical cardiac support in patients with dilated cardiomyopathy. Circulation. 1997;96:542-549.
12. Hetzer R, Müller J, Weng Y, Wallukat G, Spegelsberger S, Loebe M. Cardiac recovery in dilated cardiomyopathy by unloading with a left ventricular assist device. Ann Thorac Surg. 1999;68:742-749.
13. Dandel M, Weng Y, Sinawski H, Potapov E, Lehmkuhl HB, Hetzer R. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation. 2005;112:I-37-I-45.
14. Birks EJ, Tansley PD, Hardy J, George RS, Bowlws CT, Burke M, Banner NR, Khagani A, Yacoub MH. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med 2006;355: 1873-1884.
15. Mano A, Nakatani T, Oda N. Kato T, Niwaya K, Tagusari O, Nakajima H, Funatsu T, Hashimoto S, Komamura K, Hanatani A, Ueda IH, Kitakaze M, Kobayashi J, Yagihara T, Kitamura S. Which factors predict the recovery of natural heart function after insertion of a left ventricular assist system J Heart Lung Transplant. 2008;27:869-874.
16. Simon MA, Primack BA, Teuteberg J, Kormos RL, Bermudez C, Toyoda Y, Shah H, Gorcsan J III, McNamara DM. Left ventricular remodeling and myocardial recovery on mechanical circulatory support. J Card Fail. 2010;16:99-105.
17. Dandel M, Weng Y, Siniawski H, Potapov E, Drews T, Lehmkuhl HB, Knosalla C, Hetzer R. Prediction of cardiac stability after weaning from ventricular assist devices in patients with idiopathic dilated cardiomyopathy. Circulation. 2008;118:S94-S105.
18. Matsumiya G, Monta O, Fukushima N, Sawa Y, Funatsu T, Toda K, Matsuda H. Who would be a candidate for bridge to recovery during prolonged mechanical left ventricular support in idiopathic dilated cardiomyopathy. J Thorac Cardiovasc Surg. 2005;130:699-704.
19. Dandel M, Weng Y, Siniawski H, Stepanenko A, Krabatsch T, Potapov E, Lehmkuhl HB, Knosalla C, Hetzer R. Heart failure reversal by ventricular unloading in patients with chronic cardiomyopathy: criteria for weaning from ventricular assist devices. Eur Heart J. 2011;32: 1148-1160.
20. Dandel M, Hummel M, Mü ller J, Wellnhofer E, Meyer R, Solowjowa N, Ewert R, Hetzer R. Reliability of tissue Doppler wall motion monitoring after heart transplantation for the replacement of invasive routine screenings by optimally timed cardiac biopsies and catheterizations. Circulation. 2001;104:184-191.
21. Frazier OH, Delgado RM, Scroggins M, Odegaard P, Kar B. Mechanical bridging to improvement in severe acute "nonischemic, nonmyocarditis" heart failure. Congest Heart Fail. 2004;10:109-113.
22. Aurigemma GP, Douglas PS, Gaasch HW. Quantitative evaluation of left ventricular structure, wall stress and systolic function. In: Otto CM, editor. The Practice of Clinical Echocardiography. Philadelphia: WB Saunders Company; 2002:65-87.
23. Dandel M, Hetzer R. Echocardiographic strain and strain rate imaging: clinical applications. Int J Cardiol. 2009;132:11-24.
24. Dandel M, Wellhofer E, Hummel M, Meyer R, Lehmkuhl HB, Hetzer R. Early detection of left ventricular dysfunction related to transplant coronary artery disease. J Heart Lung Transplant. 2003;22:1353-1364.