Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression

Molecular Medicine Reports

Volumn 6, Issue 5, 2012, Pages 1040-1044

  Qin, Jie ^a   Wang, Yunbin ^b   Bai, Yu ^c   Yang, Kai ^a   Mao, Qiqi ^a   Lin, Yiwei ^a   Kong, Debo ^a   Zheng, Xiangyi ^a   Xie, Liping ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INNER MONGOLIA MEDICAL COLLEGE   (China)

^c Tumor Hospital of Yunnan   (China)

Author keywords

Bladder cancer; Epigallocatechin gallate; Invasion; Matrix metalloproteinase 9; Nuclear factor B

Indexed keywords

EPIGALLOCATECHIN GALLATE; FIBRONECTIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; BLADDER CANCER; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; METASTASIS INHIBITION; PROTEIN EXPRESSION;

ANTICARCINOGENIC AGENTS; CATECHIN; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; FIBRONECTINS; HUMANS; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; URINARY BLADDER NEOPLASMS;

EID: 84866458289     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1054     Document Type: Article

References (21)

1. Ashughyan VR, Marihart S and Djavan B: Chemopreventive trials in urologic cancer. Rev Urol 8: 8-13, 2006.
2. Pectasides D, Pectasides M and Nikolaou M: Adjuvant and neoadjuvant chemotherapy in muscle invasive bladder cancer: literature review. Eur Urol 48: 60-67; discussion 67-68, 2005.
3. Khan N, Afaq F, Saleem M, Ahmad N and Mukhtar H: Targeting multiple signaling pathways by green tea polyphenol (-)-epigallo-catechin-3-gallate. Cancer Res 66: 2500-2505, 2006.
4. Yang CS, Maliakal P and Meng X: Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42: 25-54, 2002. (Pubitemid 34160518)
5. Kemberling JK, Hampton JA, Keck RW, Gomez MA and Selman SH: Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate. J Urol 170: 773-776, 2003. (Pubitemid 36999553)
6. Liotta LA and Stetler-Stevenson WG: Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 51 (Suppl 18): 5054s-5059s, 1991.
7. Choi YD, Cho NH, Ahn HS, Cho KS, Cho SY and Yang WJ: Matrix metalloproteinase expression in the recurrence of superficial low grade bladder transitional cell carcinoma. J Urol 177: 1174-1178, 2007. (Pubitemid 46216371)
8. Di Carlo A, Terracciano D, Mariano A and Macchia V: Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors. Oncol Rep 15: 1321-1326, 2006.
9. Liu J, Zhang X, Yang F, Li T, Wei D and Ren Y: Antimetastatic effect of a lipophilic ascorbic acid derivative with antioxidation through inhibition of tumor invasion. Cancer Chemother Pharmacol 57: 584-590, 2006. (Pubitemid 43237842)
10. Suzuki Y and Isemura M: Inhibitory effect of epigallocatechin gallate on adhesion of murine melanoma cells to laminin. Cancer Lett 173: 15-20, 2001. (Pubitemid 32907504)
11. Hochman E, Castiel A, Jacob-Hirsch J, Amariglio N and Izraeli S: Molecular pathways regulating pro-migratory effects of Hedgehog signaling. J Biol Chem 281: 33860-33870, 2006. (Pubitemid 46036598)
12. Garbisa S, Biggin S, Cavallarin N, Sartor L, Benelli R and Albini A: Tumor invasion: molecular shears blunted by green tea. Nat Med 5: 1216, 1999. (Pubitemid 29535569)
13. Meng Q, Qi M, Chen DZ, et al: Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J Mol Med (Berl) 78: 155-165, 2000. (Pubitemid 30337497)
14. Qin J, Xie LP, Zheng XY, et al: A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins. Biochem Biophys Res Commun 354: 852-857, 2007. (Pubitemid 46216211)
15. Overall CM and López-Otin C: Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2: 657-672, 2002.
16. Chakraborti S, Mandal M, Das S, Mandal A and Chakraborti T: Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem 253: 269-285, 2003.
17. Kim D, Kim S, Koh H, et al: Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15: 1953-1962, 2001. (Pubitemid 32848799)
18. Rangaswami H, Bulbule A and Kundu GC: Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IκBα kinase-dependent nuclear factor κB-mediated promatrix metalloproteinase-9 activation. J Biol Chem 279: 38921-38935, 2004. (Pubitemid 39296053)
19. Chiang GJ, Billmeyer BR, Canes D, et al: The src-family kinase inhibitor PP2 suppresses the in vitro invasive phenotype of bladder carcinoma cells via modulation of Akt. BJU Int 96: 416-422, 2005. (Pubitemid 41097693)
20. Rieger-Christ KM, Lee P, Zagha R, et al: Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway. Oncogene 23: 4745-4753, 2004. (Pubitemid 38859462)
21. Wu X, Obata T, Khan Q, Highshaw RA, De Vere White R and Sweeney C: The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion. BJU Int 93: 143-150, 2004. (Pubitemid 38112985)