The Ever-Evolving Concept of Clinical Significance and the Potential for Sins of Omission in Genetic Research

American Journal of Bioethics

Volumn 12, Issue 10, 2012, Pages 22-24

  Costain, Gregory ^a   Bassett, Anne S ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ETHICS; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; INTERPERSONAL COMMUNICATION; MALE; RESEARCH SUBJECT;

GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENETIC VARIATION; HUMANS; MALE; RESEARCH SUBJECTS; TRUTH DISCLOSURE;

EID: 84866456716     PISSN: 15265161     EISSN: 15360075     Source Type: Journal    
DOI: 10.1080/15265161.2012.699142     Document Type: Article

References (10)

1. Ashida, S., Koehly, L. M., Roberts, J. S., Chen, C. A., Hiraki, S. and Green, R. C. 2010. The role of disease perceptions and results sharing in psychological adaptation after genetic susceptibility testing: The REVEAL study. European Journal of Human Genetics, 18(12): 1296-1301.
2. Bloss, C. S., Schork, N. J. and Topol, E. J. 2011. Effect of direct-to-consumer genomewide profiling to assess disease risk. New England Journal of Medicine, 364(6): 524-534.
3. Bollinger, J. M., Scott, J., Dvoskin, R. and Kaufman, D. 2012. Public preferences regarding the return of individual genetic research results: Findings from a qualitative focus group study. Genetics in Medicine, 14(4): 451-457.
4. Carvajal-Carmona, L. G. 2010. Challenges in the identification and use of rare disease-associated predisposition variants. Current Opinion in Genetics & Development, 20(3): 277-281.
5. Chan, B., Facio, F. M., Eidem, H., Hull, S. C., Biesecker, L. G. and Berkman, B. E. 2012. Genomic inheritances: Disclosing individual research results from whole-exome sequencing to deceased participants' relatives. American Journal of Bioethics, 12(10): 1-8.
6. Costain, G., Chow, E. W., Ray, P. N. and Bassett, A. S. 2012. Caregiver and adult patient perspectives on the importance of a diagnosis of 22q11.2 deletion syndrome. Journal of Intellectual Disability Research, 56(6): 641-651.
7. National Cancer Institute. 2010. Workshop on Release of Research Results to Participants in Biospecimen Studies Bethesda, MD Available at: http://biospecimens.cancer.gov/resources/publications/workshop/rrra.asp (accessed May 21, 2012)
8. Scherer, S. W. and Dawson, G. 2011. Risk factors for autism: Translating genomic discoveries into diagnostics. Human Genetics, 130(1): 123-148.
9. Tassé, A. M. 2011. The return of results of deceased research participants. Journal of Law, Medicine & Ethics, 39(4): 621-630.
10. Williams, J. K., Erwin, C., Juhl, A., Mills, J., Brossman, B. and Paulsen, J. S. 2010. Personal factors associated with reported benefits of Huntington disease family history or genetic testing. Genetic Testing and Molecular Biomarkers, 14(5): 629-636.