Cerebral microembolization after bioprosthetic aortic valve replacement: Comparison of warfarin plus aspirin versus aspirin only

Circulation

Volumn 126, Issue 11 SUPPL.1, 2012, Pages

  Al Atassi, Talal ^a   Lam, Khanh ^a   Forgie, Melissa ^a   Boodhwani, Munir ^a   Rubens, Fraser ^a   Hendry, Paul ^a   Masters, Roy ^a   Goldstein, William ^a   Bedard, Pierre ^a   Mesana, Thierry ^a   Ruel, Marc ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

anticoagulation; bioprosthetic aortic valve replacement; cerebral embolization

Indexed keywords

ACETYLSALICYLIC ACID; COLLAGEN; WARFARIN;

AGED; AORTA VALVE REPLACEMENT; ARTICLE; BRAIN EMBOLISM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOTHERAPY; OPEN STUDY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; AORTIC VALVE STENOSIS; ASPIRIN; BIOPROSTHESIS; COLLAGEN; CORONARY ARTERY BYPASS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEART VALVE PROSTHESIS; HEART VALVE PROSTHESIS IMPLANTATION; HEMORRHAGE; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MIDDLE AGED; P-SELECTIN; PLATELET ACTIVATION; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; WARFARIN;

EID: 84866454957     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.084772     Document Type: Article

References (29)

1. Dellgren G, David TE, Raanani E, Armstrong S, Ivanov J, Rakowski H. Late hemodynamic and clinical outcomes of aortic valve replacement with the Carpentier-Edwards Perimount pericardial bioprosthesis. J Thorac Cardiovasc Surg. 2002;124:146-154.
2. Florath I, Albert A, Rosendahl U, Alexander T, Ennker IC, Ennker J. Mid-term outcome and quality of life after aortic valve replacement in elderly people: mechanical versus stentless biological valves. Heart. 2005;91:1023-1029.
3. Bonow RO, Carabello B, de Leon AC Jr, Chatterjee K, de Leon AC Jr, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS. ACC/AHA guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol. 1998;32: 1486-1582.
4. Golke-Barwolf C, Acar J, Oakley C, Butchart E, Burckhart D, Bodnar E, Hall R, Delahaye JP, Horstkotte D, Krémer R. Guidelines for prevention of thromboembolic events in valvular heart disease. Eur Hear J. 1995; 16:1320-1330.
5. Stein PD, Alpert JS, Bussey HI, Dalen JE, Turpie AG. Antithrombotic therapy in patients with mechanical and biological prosthetic heart valves: Sixth ACCP Consensus Conference on Antithrombotic Therapy. Chest. 2001;119(Suppl):220s-227s.
6. Vaughan P, Waterworth PD. An audit of anticoagulation practice among UK Cardiothoracic Consultant surgeons following valve replacement/repair. J Heart Valve Dis. 2005;14:576-582.
7. Sundt TM, Zehr KJ, Dearani JA, Daly RC, Mullany CJ, McGregor CGA, Puga FJ. Orszulak TA, Schaff HV. Is early anticoagulation with warfarin necessary after bioprosthetic aortic valve replacement? J Thorac Cardiovasc Surg. 2005;129:1024-1031.
8. Di Marco F, Giordan M, Gerosa G. Early antithrombotic therapy after aortic valve replacement with tissue valves: when the practice diverges from the guidelines. J Thorac Cardiovasc Surg. 2005;131:1223.e1-1223.e3.
9. Heras M, Chesebro JH, Fuster F, Penny WJ, Grill DE, Bailey KR, Danielson GK, Orszulak TA, Pluth JR, Puga FJ, Schaff HV, Larsonkeller J. High risk of thromboembolic early after bioprosthetic cardiac valve replacement. J Am Coll Cardiol. 1995;25:I111-I119.
10. Moinuddeen K, Quin J, Shaw R, DewarM, Tellides G, Kopf G, Elefteriades J. Anticoagulation is unnecessary after biological aortic valve replacement. Circulation. 1998;98(19 Suppl):II95-II98; discussion II98-II99.
11. Gherli T, Colli A, Fragnito C, Nicolini F, Borrello B, Saccani S, D'Amico R, Beghi C. Comparing warfarin with aspirin after biological aortic valve replacement: a prospective study. Circulation. 2004;110:496-500.
12. Rodriguez RA, Rubens F, Rodriguez CD, Nathan HJ. Sources of variability in the detection of cerebral emboli with transcranial Doppler during cardiac surgery. J Neuroimaging. 2006;16:126-132.
13. Kobune K, Inoue M, Morikawa M, Tsuboi M, Takami Y, Iwane Y, Kudo T. Effects of combination therapy with low-dose aspirin and warfarin on platelet functions after heart valve replacement. Res Comm Chem Pathol Pharmacol. 1991;74:153-165.
14. Zimmerman N, Wenk A, Kim U, Kienzle P, Weber A, Gams E, Schror K, Hohlfel T. Functional and biochemical evaluation of platelet aspirin resistance after coronary bypass surgery. Circulation. 2003;108:542-547.
15. Rodriguez RA, Williams KA, Babaev A, Rubens F, Nathan HJ. Effect of perfusionist technique on cerebral embolization during cardiopulmonary bypass. Perfusion. 2005;20:3-10.
16. Zimmerman N, Roussiekan T, Winter J, Kurt M, Gams E, Wenzel F, Hohlfeld T. Platelet inhibition by aspirin after aortic valve replacement. J Thorac Cardiovasc Surg. 2006;131:1392-1393.
17. Berry CB, Myles PS. Preoxygenation in healthy volunteers: a graph of oxygen "washin" using end-tidal oxygraphy. Br J Anaesth. 1994;72: 116-118.
18. Blackwelder WC. Proving the null hypothesis in clinical trials. Controlled Clin Trials. 1982;3:345-353.
19. Grosset DG, Georgiadis D, Stirling S, Cowburn P, Kelman AW, Faichney A, Lees KR. Subclinical embolism in patients undergoing cardiac valve implantation and coronary artery bypass surgery. Eur J Cardiothorac Surg. 1994;8:63-66.
20. Sturzenegger M, Beer JH, Rihs F. Monitoring combined antithrombotic treatments in patients with prosthetic heart valves using transcranial Doppler and coagulation markers. Stroke. 1995;26:63-69.
21. Rams JJ, Davis DA, Lolley DM, Berger MP, Spencer M. Detection of microemboli in patients with artificial heart valves using transcranial Doppler: preliminary observations. J Heart Valve Dis. 1993;2:37-41.
22. Kleine P, Perthel M, Hasenkam JM, Nygaard H, Hansen SB, Laas J. Downstream turbulence and high intensity transient signals (HITS) following aortic valve replacement with Medtronic Hall or St Jude Mechanical valve substitutes. Eur J Cardiothorac Surg. 2000;17:20-24.
23. Andersen TS, Johansen P, Paulsen PK, Nygaard H, Hasenkam JM. Indication of cavitation in mechanical heart valve patients. J Heart Valve Dis. 2003;12:790-796.
24. Droste DW, Hansberg T, Kemeny V, Hammel D, Schulte-Altedorneburg G, Nabavi DG, Kaps M, Scheld HH, Ringelstein EB. Oxygen inhalation can differentiate gaseous from nongaseous microemboli by transcranial Doppler ultrasound. Stroke. 1997;28:2453-2456.
25. Milano A, D'Alfonso A, Codecasa R, De Carlo M, Nardi C, Orlandi G, Landucci L, Bortolotti U. Prospective evaluation of frequency and nature of transcranial high intensity Doppler signals in prosthetic valve recipients. J Heart Valve Dis. 1999;8:488-494.
26. Skjelland M, Michelsen A, Brosstad F, Svennevig JL, Brucher R, Russel D. Solid cerebral microemboli and cerebrovascular symptoms in patients with prosthetic heart valves. Stroke. 2008;39:1159-1164.
27. Schuhlen H, Hadamitzky M, Walter H, Ulm K, Schomig A. Major benefits from antiplatelet therapy for patients at high risk for adverse cardiac events after coronary Palmaz-Schatz stent replacement. Circulation. 1997;95: 2015-2021.
28. Urban P, Macaya C, Rupprecht HJ, Kiemeneij F, Emanuelson H, Fontanelli A, Pieper M, Wesseling T, Sagnard L. Randomized evaluation of anticoagulation versus antiplatelet therapy after coronary stent implantation in high-risk patients. Circulation. 1998;98:2126-2132.
29. Schlitt A, von Bardeleben RS, Ehrlich A, Eimermarcher A, Peetz D, Dahm M, Rupprecht H. Clopidogrel and aspirin in the prevention of thromboembolic complications after mechanical aortic valve replacement (CAPTA). Thromb Res. 2003;109:131-135.