Homocysteine, renal function, and risk of cardiovascular disease

Kidney International, Supplement

Volumn 63, Issue 84, 2003, Pages

  Clarke, Robert ^a   Lewington, Sarah ^a   Landray, Martin ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

Heart disease; Homocysteine; Kidney function; Stroke

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CREATININE; FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONFERENCE PAPER; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; GENETIC RISK; GENOTYPE; HOMOCYSTINURIA; HUMAN; ISCHEMIC HEART DISEASE; KIDNEY DISEASE; KIDNEY FUNCTION; META ANALYSIS; PRIORITY JOURNAL; STROKE; ARTICLE; BLOOD; CEREBROVASCULAR ACCIDENT; HYPERHOMOCYSTEINEMIA; KIDNEY; PHYSIOLOGY; PROSPECTIVE STUDY; RISK FACTOR;

CEREBROVASCULAR ACCIDENT; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; KIDNEY; KIDNEY DISEASES; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 0037406436     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.63.s84.7.x     Document Type: Conference Paper

References (25)

1. WILCKEN DE, WILCKEN B: The pathogenesis of coronary artery disease. A possible role for methionine metabolism. J Clin Invest 57(4):1079-1082, 1976
2. CLARKE R, DALY L, ROBINSON K, et al: Hyperhomocysteinemia: An independent risk factor for vascular disease. N Engl J Med 324(17):1149-1155, 1991
3. BOUSHEY CJ, BERESFORD SA, OMENN GS, MOTULSKY AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274(13):1049-1057, 1995
4. DANESH J, LEWINGTON S: Plasma homocysteine and coronary heart disease: Systematic review of published epidemiological studies. J Cardiovasc Risk 5(4):229-232, 1998
5. CHAUVEAU P, CHADEFAUX B, COUDÉ M, et al: Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients. Kidney Int 43(Suppl 41):S72-S77, 1993
6. ARNADOTTIR M, HULTBERG B, NILSSON-EHLE P, THYSELL H: The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Invest 56:41-46, 1996
7. LANDRAY MJ, THAMBYRAJAH J, McGLYNN FJ, et al: Epidemiological evaluation of known and suspected cardiovascular risk factors in chronic renal impairment. Am J Kidney Dis 38:537-546, 2001
8. HULTBERG B, ANDERSSON A, STERNER G: Plasma homocysteine in renal failure. Clin Nephrol 40:230-235, 1993
9. FOLEY RN, PARFREY PS, SARNAK MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32(Suppl 3):S112-S119, 1998
10. DUDMAN NPB: An alternative view of homocysteine. Lancet 354:2072-2074, 1999
11. BRATTSTROM L, WILCKEN DEL: Homocysteine and cardiovascular disease: Cause or effect? Am J Clin Nutr 72:315-323, 2000
12. LANDRAY MJ, BAIGENT C: Renal function: An emerging risk factor for cardiovascular disease? Evidence-based Cardiovasc Med 5:32-33, 2001
13. HOMOCYSTEINE STUDIES COLLABORATION: Homocysteine and risk of ischemic heart disease and stroke: 6000 events in 30 observational studies. JAMA 2002 (In-press).
14. FROSST P, BLOM HJ, MILOS R, et al: A candidate genetic risk factor for vascular disease: A common mutation in methylene-tetrahydrofolate reductase. Nat Genet 10:111-113, 1995
15. KLERK M, VERHOEF P, CLARKE R, et al: MTHFR C677C>T polymorphism and risk of coronary heart disease: Meta-analysis of 40 studies. JAMA 288:2023-2031, 2002
16. BOSTOM AG, BAUSSERMAN L, JACQUES PF, et al: Cystatin C as a determinant of fasting plasma total homocysteine levels in coronary artery disease patients with normal serum creatinine. Arterioscler Thromb Vasc Biol 19:2241-2244, 1999
17. NORLUND L, GRUBB A, FEX G, et al: The increase of plasma homocysteine concentration with age is partly due to the deterioration of renal function as determined by plasma cystatin C. Clin Chem Lab Med 36:175-178, 1998
18. WOLLESEN F, BRATTSTRÖM B, REFSUM H, et al: Plasma homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int 55:1028-1035, 1999
19. CLARKE R, REFSUM H, BIRKS J, et al: Screening for vitamin B12 and folate deficiency in older people. Am J Clin Nutr, 2003 (in press)
20. SELHUB J, JACQUES PF, WILSON PW, et al: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693-8, 1993
21. MOUSTAPHA A, NASO A, NAHLAWI M, et al: Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 97(2):138-141, 1998
22. JUNGERS P, MASSY ZA, KHOA TN, et al: Incidence and risk factors of atherosclerotic cardiovascular accidents in predialysis chronic renal failure patients: A prospective study. Nephrol Dial Transplant 12:2597-2602, 1997
23. Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials. BMJ 316:894-8, 1998.
24. THAMBYRAJAH J, LANDRAY MJ, McGLYNN FJ, et al: Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure? Circulation 102:871-875, 2000
25. CLARKE R, COLLINS R: Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease. J Cardiovasc Risk 5(4):249-255, 1998