Heart rate variability predicts cell death and inflammatory responses to global cerebral ischemia

Frontiers in Physiology

Volumn 3 MAY, Issue , 2012, Pages

  Norman, Greg J ^a   Karelina, Kate ^b   Berntson, Gary G ^b   Morris, John S ^b   Zhang, Ning ^b   DeVries, A Courtney ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Autonomic; Cardiac; Cardiac arrest; Ischemia; Parasympathetic

Indexed keywords

EID: 84866428068     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00131     Document Type: Article

References (34)

1. American Heart Association. (2002). Heart Disease and Stroke Statistics: 2003 Update. Dallas, TX: American Heart Association.
2. Berntson, G. G., Bigger, J. T. Jr., Eck-berg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., Nagaraja, H. N., Porges, S. W., Saul, J. P., Stone, P. H., and van der Molen, M. W. (1997). Heart rate variability: origins, methods, and interpretive caveats. Psy-chophysiology 34, 623-648.
3. Berntson, G. G., Cacioppo, J. T., Bink-ley, P. F., Uchino, B. N., Quigley, K. S., and Fieldstone, A. (1994). Auto-nomic cardiac control. III. Psychological stress and cardiac response in autonomic space as revealed by pharmacological blockades. Psy-chophysiology 31, 599-608.
4. Berntson, G. G., Norman, G. J., Hawkley, L. C., and Cacioppo, J. T. (2008). Cardiac autonomic balance versus cardiac regulatory capacity. Psychophysiology 45, 643-652.
5. Bigger, J. T. Jr., Kleiger, R. E., Fleiss, J. L., Rolnitzky, L. M., Steinman, R. C., and Miller, J. P. (1988). Components of heart rate variability measured during healing of acute myocar-dial infarction. Am. J. Cardiol. 61, 208-215.
6. Cronberg, T., Lilja, G., Rundgren, M., Friberg, H., and Widner, H. (2009). Long-term neurological outcome after cardiac arrest and therapeutic hypothermia. Resuscitation 80, 1119-1123.
7. Fairchild, K. D., Srinivasan, V., Moorman, J. R., Gaykema, R. P., and Goehler, L. E. (2011). Pathogen-induced heart rate changes associated with cholinergic nervous system activation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R330-R339.
8. Gehrmann, J., Hammer, P. E., Maguire, C. T., Wakimoto, H., Triedman, J. K., and Berul, C. I. (2000). Phenotypic screening for heart rate variability in the mouse. Am. J. Physiol Heart Circ. Physiol. 279, H733-H740.
9. Haensel, A., Mills, P. J., Nelesen, R. A., Ziegler, M. G., and Dimsdale, J. E. (2008). The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology 33, 1305-1312.
10. Huikuri, H. V., Raatikainen, M. J., Moerch-Joergensen, R., Har-tikainen, J., Virtanen, V., Boland, J., Anttonen, O., Hoest, N., Boersma, L. V., Platou, E. S., Messier, M. D., and Bloch-Thomsen, P. E. (2009). Cardiac Arrhythmias and risk stratification after acute myocardial infarction study group. Eur. Heart J. 30, 689-698.
11. Karelina, K., Norman, G. J., Zhang, N., and DeVries, A. C. (2009). Social contact influences histological and behavioral outcomes following cerebral ischemia. Exp. Neurol. 220, 276-282.
12. Karp, E., Shiyovich, A., Zahger, D., Gilutz, H., Grosbard, A., and Katz, A. (2009). Ultra-short-term heart rate variability for early risk stratification following acute ST-elevation myocardial infarction. Cardiology 114,275-283.
13. Kofler, J., Hattori, K., Sawada, M., DeVries, A. C., Martin, L. J., Hurn, P. D., and Traystman, R. J. (2004). Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. J. Neurosci. Methods 136, 33-44.
14. Kox, M., Ramakers, B. P., Pompe, J. C., van der Hoeven, J. G., Hoedemaek-ers, C. W., and Pickkers, P. (2011). Interplay between the acute inflammatory response and heart rate variability in healthy human volunteers. Shock 36,115-120.
15. La Rovere, M. T., Bigger, J. T. Jr., Marcus, F. I., Mortara, A., and Schwartz, P. J. (1998). Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes after Myocardial Infarction) Investigators. Lancet 351, 478-484.
16. Malik, M. (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93,1043-1065.
17. Marsland, A. L., Gianaros, P. J., Prather, A. A., Jennings, J. R., Neumann, S. A., and Manuck, S. B. (2007). Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability. Psychosom. Med. 69, 709-716.
18. Micieli, G., and Cavallini, A. (2008). The autonomic nervous system and ischemic stroke: a reciprocal interdependence. Clin. Auton. Res. 18, 308-317.
19. Neigh, G. N., Karelina, K., Zhang, N., Glasper, E. R., Owens, M. J., Plotsky, P. M., Nemeroff, C. B., and Devries, A C. (2009). Cardiac arrest and car-diopulmonary resuscitation dysreg-ulates the hypothalamic-pituitary-adrenal axis. J. Cereb. Blood Flow Metab.
20. Norman, G. J., Berntson, G. G., Morris, J. S., Karelina, K., Zhang, N., Weil, Z. M., and DeVries, A. C. (2010a). Social isolation exacerbates autonomic, inflammatory and behavior responses to global cerebral ischemia. Proc. Natl. Acad. Sci. U.S.A. 107, 16342-16347.
21. Norman, G. J., Karelina, K., Berntson, G. G., Weil, Z. M., Zhang, N., Morris, J. S., Al-Abed, Y., Pavlov, V. A., Tracey, K. J., and DeVries, A. C. (2010b). Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors. J. Neurosci. 31,3446-3452.
22. Offner, H., Vandenbark, A. A., and Hurn, P. D. (2009). Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuro-science 158, 1098-1111.
23. Oppenheimer, S. M., Kedem, G., and Martin, W. M. (1996). Left-insular cortex lesions perturb cardiac autonomic tone in humans. Clin. Auton. Res. 6, 131-140.
24. Popovich, P. G., Wei, P., and Stokes, B T. (1997). Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J. Comp. Neurol. 377,443-464.
25. Ruit, K. G., and Neafsey, E. J. (1988). Cardiovascular and respiratory responses to electrical and chemical stimulation of the hippocampus in anesthetized and awake rats. Brain Res. 457, 310-321.
26. Sans, S., Kesteloot, H., and Kromhout, D. (1997). The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur. HeartJ. 18,1231-1248.
27. Schmued, L. C., and Hopkins, K. J. (2000). Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874, 123-130.
28. Sloan, R. P., McCreath, H., Tracey, K. J., Sidney, S., Liu, K., and Seeman, T. (2007). RR interval variability is inversely related to inflammatory markers: The CARDIA study. Mol. Med. 13, 178-184.
29. Thayer, J. F., Hansen, A. L., Saus-Rose, E., and Johnsen, B. H. (2009). Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Ann. Behav. Med. 37, 122-129.
30. Thayer, J. F., and Lane, R. D. (2007). The role of vagal function in the risk for cardiovascular disease and mortality. Biol. Psychol. 74,224-242.
31. Thireau, J., Zhang, B. L., Poisson, D., and Babuty, D. (2008). Heart rate variability in mice: a theoretical and practical guide. Exp. Physiol. 93, 83-94.
32. Tracey, K. J. (2009). Reflex control of immunity. Nat. Rev. Immunol. 9, 418-428.
33. Wenk, G. L., and Willard, L. B. (1998). The neural mechanisms underlying cholinergic cell death within the basal forebrain. Int. J. Dev. Neurosci. 16, 729-735.
34. Yenari, M. A., Kauppinen, T. M., and Swanson, R. A. (2010). Microglial activation in stroke: therapeutic targets. Neurotherapeutics 7, 378-391.