Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS)

Journal of Mass Spectrometry

Volumn 47, Issue 9, 2012, Pages 1092-1097

  Jürschik, Simone ^a,b   Agarwal, Bishu ^b   Kassebacher, Thomas ^b   Sulzer, Philipp ^a   Mayhew, Christopher A ^c   Märk, Tilmann D ^a,b  

^a IONICON Analytik GmbH   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

contamination monitoring; drink spiking; food safety; proton transfer reaction; PTR MS; PTR TOFMS; rape drug detection

Indexed keywords

CONTAMINATION MONITORING; DRINK SPIKING; DRUG DETECTION; PROTON TRANSFER REACTIONS; PTR-MS; PTR-TOFMS;

BEVERAGES; ELECTRIC FIELDS; FOOD SAFETY; HYDRATES; MASS SPECTROMETRY;

CHARGE TRANSFER;

BUTANEDIOL; CHLORAL HYDRATE; GAMMA BUTYROLACTONE; TRICHLOROETHANOL; WATER;

CONFERENCE PAPER; DRUG CONTAMINATION; DRUG DETERMINATION; ELECTRIC FIELD; FOOD CONTAMINATION; PRIORITY JOURNAL; PROTON TRANSFER REACTION MASS SPECTROMETRY; PROTON TRANSPORT; QUADRUPOLE MASS SPECTROMETRY; RED WINE; TEA; TIME OF FLIGHT MASS SPECTROMETRY;

4-BUTYROLACTONE; BEVERAGES; BUTYLENE GLYCOLS; CHLORAL HYDRATE; HYPNOTICS AND SEDATIVES; MASS SPECTROMETRY; RAPE; SENSITIVITY AND SPECIFICITY; SUBSTANCE ABUSE DETECTION;

EID: 84866424005     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.2993     Document Type: Conference Paper

References (23)

1. W. Lindinger, A. Hansel, A. Jordan,. On-line monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass-spectrometry (PTR-MS): Medical applications, food control and environmental research. Int. J. Mass Spectrom. Ion Proc. 1998, 173, 191.
2. D. Mayr, R. Margesin, E. Klingsbichel, E. Hartungen, D. Jenewein, F. Schinner, T. D. Märk,. Rapid Detection of Meat Spoilage by Measuring Volatile Organic Compounds by Using Proton Transfer Reaction Mass Spectrometry. Appl. Environ. Microbiol. 2003, 69, 4697.
3. C. Lindinger, D. Labbe, P. Pollien, A. Rytz, M. A. Juillerat, C. Yeretzian, I. Blank,. When Machine Tastes Coffee: Instrumental Approach To Predict the Sensory Profile of Espresso Coffee. Anal. Chem. 2008, 80, 1574.
4. F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk,. PTR-MS monitoring of VOCs and BVOCs in food science and technology. Trends Anal. Chem. 2011, 30 (7), 968.
5. F. Petersson, P. Sulzer, C.A. Mayhew, P. Watts, A. Jordan, L. Märk, T.D. Märk,. Real-time trace detection and identification of chemical warfare agent simulants using recent advances in proton transfer reaction time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23, 3875.
6. B. Agarwal, F. Petersson, S. Jürschik, P. Sulzer, A. Jordan, T. D. Märk, P. Watts, C. A. Mayhew,. Use of proton transfer reaction time-of-flight mass spectrometry for the analytical detection of illicit and controlled prescription drugs at room temperature via direct headspace sampling. Anal. Bioanal. Chem. 2011, 400, 2631.
7. C. Basheer,. Recent analytical strategies on "Date-Rape" Drugs and its metabolites. J. Appl. Pharm. Sci. 2011, 1 (6), 21.
8. R.R. Miller, D.J. Greenblatt,. Clinical effects of chloral hydrate in hospitalized medical patients. J. Clin. Pharmacol. 1979, 19 (10), 669.
9. Z. Yan, G. N. Henderson, M. O. James, P. W. Stacpoole,. Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry. J. Pharmaceut. Biomed. 1999, 19, 309.
10. C. Haller, D. Thai, P. Jacob III, J.E. Dyer,. GHB urine concentrations after single-dose administration in humans. J. Anal. Toxicol. 2006, 30 (6), 360.
11. R. Wischnewski,. presentation at the 32. BundesDrogenKongress, Erfurt, 2009, http://fdr-online.info/media/BundesDrogenKongress/32.BundesDrogenKongress/ S-11-Wischnewski.pdf (accessed 27.12.2011)
12. R.H. Roth, N.J. Giarman,. Preliminary report on the metabolism of γ -butyrolactone and γ -hydroxybutyric acid. Biochem. Pharmacol. 1965, 14, 177.
13. F. Poldrugo, O.C. Snead III,. 1,4 butanediol, γ -hydroxybutyric acid and ethanol: relationships and interactions. Neuropharmacology 1984, 23, 109.
14. A. B. Schneir, B. T. Ly, R. F. Clark,. A case of withdrawal from the GHB precursors gamma-butyrolactone and 1,4-butanediol. J. Emerg. Med. 2001, 21 (1), 31.
15. J. Dahlen, T. Vriesman,. Simultaneous analysis of γ -hydroxybutyric acid, γ -butyrolactone, and 1,4- butanediol by micellar electrokinetic chromatography. Forensic Sci. Int. 2002, 125, 113.
16. M. L. Patchett, Y. Minoshima, P. B. Harrington,. Detection of γ-hydroxybutyrate and γ -butyrolactone by Ion Mobility Spectrometry. Spectroscopy 2002, 17 (11), 16.
17. S. C. Bishop,. Advanced electrophoretic techniques for the detection of date-rape and club drugs for a forensic setting, PhD thesis, College of Arts and Sciences of Ohio University, 2004.
18. T. Wang, P. Spanel, D. Smith,. A selected ion flow tube, SIFT, study of the reactions of H3O+, NO+ and O2+ ions with several N- and O-containing heterocyclic compounds in support of SIFT-MS. Int. J. Mass. Spectrom. 2004, 237, 167.
19. A. Jordan, S. Haidacher, G. Hanel, E. Hartungen, L. Märk, H. Seehauser, R. Schottkowsky, P. Sulzer, T.D. Märk,. A high resolution and high sensitivity time-of-flight proton-transfer-reaction mass spectrometer (PTR-TOF-MS). Int. J. Mass. Spectrom. 2009, 286, 122.
20. A. Jordan, S. Haidacher, G. Hanel, E. Hartungen, J. Herbig, L. Märk, R. Schottkowsky, H. Seehauser, P. Sulzer, T.D. Märk,. An online ultra-high sensitivity proton-transfer-reaction mass-spectrometer combined with switchable reagent ion capability (PTR+SRI-MS). Int. J. Mass. Spectrom. 2009, 286, 32.
21. R. S. Blake, P. S. Monks, A. M. Ellis,. Proton-Transfer Reaction Mass Spectrometry. Chem. Rev. 2009, 109 (3), 861.
22. S. Jürschik, A. Tani, P. Sulzer, S. Haidacher, A. Jordan, R. Schottkowsky, E. Hartungen, G. Hanel, H. Seehauser, L. Märk, T.D. Märk,. Direct aqueous injection analysis of trace compounds in water with proton-transfer-reaction mass spectrometry (PTR-MS). Int. J. Mass. Spectrom. 2010, 289, 173.
23. S. Jürschik, P. Sulzer, F. Petersson, C. A. Mayhew, A. Jordan, B. Agarwal, S. Haidacher, H. Seehauser, K. Becker, T. D. Märk,. Proton transfer reaction mass spectrometry for the sensitive and rapid real-time detection of solid high explosives in air and water. Anal. Bioanal. Chem. 2010, 398, 2813.