Pancreatic ductal bicarbonate secretion: Challenge of the acinar acid load

Frontiers in Physiology

Volumn JUL, Issue , 2011, Pages

  Hegyi, Péter ^a   Maléth, József ^a   Venglovecz, Viktória ^a   Rakonczay Jr, Zoltán ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Bicarbonate; Pancreatic duct

Indexed keywords

EID: 84866415668     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2011.00036     Document Type: Short Survey

References (24)

1. Argent, B. (2006). "Cell physiology of pancreatic ducts," in Physiology of the Gastrointestinal Tract, 4th Edn, Vol. 2, ed. L. R. Johnson (San Diego: Elsevier), 1376-1396.
2. Behrendorff, N., Floetenmeyer, M., Schwiening, C., and Thorn, P. (2010). Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice. Gastroenterology 139, 1711-1720.
3. Bhoomagoud, M., Jung, T., Atladottir, J., Kolodecik, T. R., Shugrue, C., Chaudhuri, A., Thrower, E. C., and Gorelick, F. S. (2009). Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats. Gastroenterology 137, 1083-1092.
4. Clapham, D. E. (2003). TRP channels as cellular sensors. Nature 426, 517-524.
5. Dong, X., Ko, K. H., Chow, J., Tuo, B., Barrett, K. E., and Dong, H. (2011). Expression of acid-sensing ion channels in intestinal epithelial cells and their role in the regulation of duodenal mucosal bicarbonate secretion. Acta Physiol. 201, 97-107.
6. Dunn, P. M., Zhong, Y., and Burnstock, G. (2001). P2X receptors in peripheral neurons. Prog. Neurobiol. 65, 107-134.
7. Freedman, S. D., Kern, H. F., and Scheele, G. A. (2001). Pancreatic acinar cell dysfunction in CFTR-/- mice is associated with impairments in luminal pH and endocytosis. Gastroenterology 121, 950-957.
8. Haanes, K. A., and Novak, I. (2010). ATP storage and uptake by isolated pancreatic zymogen granules. Biochem. J. 429, 303-311.
9. Hegyi, P., Pandol, S., Venglovecz, V., and Rakonczay Z. Jr. (2011). The acinar-ductal tango in the pathogenesis of acute pancreatitis. Gut 60, 544-552.
10. Hegyi, P., and Rakonczay, Z. (2010). Insufficiency of electrolyte and fluid secretion by pancreatic ductal cells leads to increased patient risk for pancreatitis. Am. J. Gastroenterol. 105, 2119-2120.
11. Holzer, P. (2003). Acid-sensitive ion channels in gastrointestinal function. Curr. Opin. Pharmacol. 3, 618-625.
12. Holzer, P. (2004). TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia. Eur. J. Pharmacol. 500, 231-241.
13. Holzer, P. (2007). Taste receptors in the gastrointestinal tract. V. Acid sensing in the gastrointestinal tract. Am. J. Physiol. Gastroint. Liver Phys. 292, G699-G705.
14. Ishiguro, H., Naruse, S., Kitagawa, M., Mabuchi, T., Kondo, T., Hayakawa, T., Case, R. M., and Steward, M. C. (2002). Chloride transport in microperfused interlobular ducts isolated from guinea-pig pancreas. J. Physiol. (Lond.) 539, 175-189.
15. Kishnani, P. S., Van Hove, J. L., Shoffner, J. S., Kaufman, A., Bossen, E. H., and Kahler, S. G. (1996). Acute pancreatitis in an infant with lactic acidosis and a mutation at nucleotide 3243 in the mitochondrial DNA tRNALeu(UUR) gene. Eur. J. Pediatr. 155, 898-903.
16. Lee, M., and Muallem, S. (2008). "Physiology of duct cell secretion," in The Pancreas, 2nd Edn, eds H. Beger, M. Buchler, R. Kozarek, M. M. Lerch, J. Neoptolemos, A. Warshaw, D. Whitcomb, and K. Shiratori (Massachusetts: Blackwell Publishing), 78-91.
17. Maléth, J., Venglovecz, V., Rázga, Z., Tiszlavicz, L., Rakonczay, Z. Jr., and Hegyi, P. (2011). Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells. Gut 60, 136-138.
18. Nair, S., Yadav, D., and Pitchumoni, C. S. (2000). Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA. Am. J. Gastroenterol. 95, 2795-2800.
19. Noble, M. D., Romac, J., Vigna, S. R., and Liddle, R. A. (2008). A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis. Gut 57, 1566-1571.
20. North, R. A. (2002). Molecular physiology of P2X receptors. Physiol. Rev. 82, 1013-1067.
21. Patel, V., and Hedayati, S. S. (2006). Lactic acidosis in an HIV-infected patient receiving highly active antiretroviral therapy. Nat. Clin. Pract. Nephrol. 2, 109-114.
22. Reber, H. A., Karanjia, N. D., Alvarez, C., Widdison, A. L., Leung, F. W., Ashley, S. W., and Lutrin, F. J. (1992). Pancreatic blood flow in cats with chronic pancreatitis. Gastroenterology 103, 652-659.
23. Venglovecz, V., Rakonczay, Z. Jr., Ózsvári, B., Takács, T., Lonovics, J., Varró, A., Gray, M. A., Argent, B. E., and Hegyi, P. (2008). Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig. Gut 57, 1102-1112.
24. Yamamoto, A., Ishiguro, H., Ko, S. B. H., Suzuki, A., Wang, Y. X., Hamada, H., Mizuno, N., Kitagawa, M., Hayakawa, T., and Naruse, S. (2003). Ethanol induces fluid hypersecretion from guinea-pig pancreatic duct cells. J. Physiol. (Lond.) 551, 917-926.