Cathepsin D in human reproductive tissues: Cellular localization in testis and epididymis and surface distribution in different sperm conditions

Journal of Andrology

Volumn 33, Issue 4, 2012, Pages 726-734

  Saewu, Arpornrad ^a,b   Asuvapongpatana, Somluk ^b   Chotwiwatthanakun, Charoonroj ^c   Tantiwongse, Anuphana ^a   Weerachatyanukul, Wattana ^b   Thitilertdecha, Siriporn ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b Mahidol University ^*  (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Capacitation; Human sperm; Maturation

Indexed keywords

CATHEPSIN D;

ACROSOME; ARTICLE; CELL MATURATION; CELLULAR DISTRIBUTION; EPIDIDYMIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEYDIG CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SERTOLI CELL; SPERM; TESTIS; WESTERN BLOTTING;

ANTIGENS, SURFACE; CATHEPSIN D; EPIDIDYMIS; EPITHELIAL CELLS; HUMANS; MALE; SPERM CAPACITATION; SPERM MATURATION; SPERMATOZOA; TESTIS;

EID: 84866403062     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.111.014639     Document Type: Article

References (43)

1. Barrett AJ, Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochem J. 1970;117:601-607.
2. Berube B, Lefievre L, Coutu L, Sullivan R. Regulation of the epididymal synthesis of P26h, a hamster sperm protein. J Androl. 1996;17:104-110.
3. Brooks DE. Secretion of proteins and glycoproteins by the rat epididymis: regional differences, androgen-dependence, and effects of protease inhibitors, procaine, and tunicamycin. Biol Reprod. 1981;25:1099-1117.
4. Brooks DE, Tiver K. Analysis of surface proteins of rat spermatozoa during epididymal transit and identification of antigens common to spermatozoa, rete testis fluid and cauda epididymal plasma. J Reprod Fertil. 1984;71:249-257.
5. Cheng CY, Mruk DD. Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3. Biochem J. 2011;435:553-562.
6. Cherr GN, Yudin AI, Overstreet JW. The dual functions of GPIanchored PH-20: hyaluronidase and intracellular signaling. Matrix Biol. 2001;20:515-525.
7. Cooper TG. Interactions between epididymal secretions and spermatozoa. J Reprod Fertil Suppl. 1998;53:119-136.
8. Fehrenbacher N, Jaattela M. Lysosomes as targets for cancer therapy. Cancer Res. 2005;65:2993-2995.
9. Flesch FM, Brouwers JF, Nievelstein PF, Verkleij AJ, van Golde LM, Colenbrander B, Gadella BM. Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane. J Cell Sci. 2001;114:3543-3555.
10. Foekens JA, Look MP, Bolt-de Vries J, Meijer-van Gelder ME, van Putten WL, Klijn JG. Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients. Br J Cancer. 1999;79:300-307.
11. Frenette G, Sullivan R. Prostasome-like particles are involved in the transfer of P25b from the bovine epididymal fluid to the sperm surface. Mol Reprod Dev. 2001;59:115-121.
12. Gadella BM, Rathi R, Brouwers JF, Stout TA, Colenbrander B. Capacitation and the acrosome reaction in equine sperm. Anim Reprod Sci. 2001;68:249-265.
13. Glondu M, Liaudet-Coopman E, Derocq D, Platet N, Rochefort H, Garcia M. Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells. Oncogene. 2002;21: 5127-5134.
14. Hasilik A, Neufeld EF. Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight. J Biol Chem. 1980;255:4937-4945.
15. Hermo L, Andonian S. Regulation of sulfated glycoprotein-1 and cathepsin D expression in adult rat epididymis. J Androl. 2003;24:408-422.
16. Igdoura SA, Morales CR, Hermo L. Differential expression of cathepsins B and D in testis and epididymis of adult rats. J Histochem Cytochem. 1995;43:545-557.
17. Jones R, von Glos KI, Brown CR. Changes in the protein composition of rat spermatozoa during maturation in the epididymis. J Reprod Fertil. 1983;67:299-306.
18. Jones RC. To store or mature spermatozoa? The primary role of the epididymis. Int J Androl. 1999;22:57-67.
19. Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY, Greenbaum DC, Hager JH, Bogyo M, Hanahan D. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell. 2004;5:443-453.
20. Kornfeld S. Lysosomal enzyme targeting. Biochem Soc Trans. 1990;18:367-374.
21. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
22. Legare C, Gaudreault C, St-Jacques S, Sullivan R. P34H sperm protein is preferentially expressed by the human corpus epididymidis. Endocrinology. 1999;140:3318-3327.
23. Moura AA, Souza CE, Stanley BA, Chapman DA, Killian GJ. Proteomics of cauda epididymal fluid from mature Holstein bulls. J Proteomics. 2010;73:2006-2020.
24. Ngernsoungnern A, Weerachatyanukul W, Saewu A, Thitilertdecha S, Sobhon P, Sretarugsa P. Rat sperm AS-A: subcellular localization in testis and epididymis and surface distribution in epididymal sperm. Cell Tissue Res. 2004;318:353-363.
25. Oko RJ, Jando V, Wagner CL, Kistler WS, Hermo LS. Chromatin reorganization in rat spermatids during the disappearance of testisspecific histone, H1t, and the appearance of transition proteins TP1 and TP2. Biol Reprod. 1996;54:1141-1157.
26. Osheroff JE, Visconti PE, Valenzuela JP, Travis AJ, Alvarez J, Kopf GS. Regulation of human sperm capacitation by a cholesterol efflux-stimulated signal transduction pathway leading to protein kinase A-mediated up-regulation of protein tyrosine phosphorylation. Mol Hum Reprod. 1999;5:1017-1026.
27. Rattanachaiyanont M, Weerachatyanukul W, Leveille MC, Taylor T, D'Amours D, Rivers D, Leader A, Tanphaichitr N. Anti-SLIP1-reactive proteins exist on human spermatozoa and are involved in zona pellucida binding. Mol Hum Reprod. 2001;7:633-640.
28. Richo G, Conner GE. Proteolytic activation of human procathepsin D. Adv Exp Med Biol. 1991;306:289-296.
29. Richo GR, Conner GE. Structural requirements of procathepsin D activation and maturation. J Biol Chem. 1994;269:14,806-14,812.
30. Robaire B, Hermo L. Efferent ducts, epididymis, and vas deferens: structure, function and their regulation. In: Knobil E, Neill J, eds. The Physiology of Reproduction. New York, NY: Raven Press; 1988:999-1080.
31. Srivastava PN, Ninjoor V. Isolation of rabbit testicular cathepsin D and its role in the activation of proacrosin. Biochem Biophys Res Commun. 1982;109:63-69.
32. Towbin H, Gordon J. Immunoblotting and dot immunobinding- current status and outlook. J Immunol Methods. 1984;72:313-340.
33. Tulsiani DR, Skudlarek MD, Araki Y, Orgebin-Crist MC. Purification and characterization of two forms of beta-D-galactosidase from rat epididymal luminal fluid: evidence for their role in the modification of sperm plasma membrane glycoprotein(s). Biochem J. 1995;305(Pt 1):41-50.
34. Turk V, Kos J, Turk B. Cysteine cathepsins (proteases)-on the main stage of cancer? Cancer Cell. 2004;5:409-410.
35. Turner TT. On the epididymis and its role in the development of the fertile ejaculate. J Androl. 1995;16:292-298.
36. Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S. Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med. 2005;11:206-213.
37. Visconti PE, Ning X, Fornes MW, Alvarez JG, Stein P, Connors SA, Kopf GS. Cholesterol efflux-mediated signal transduction in mammalian sperm: cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation. Dev Biol. 1999;214:429-443.
38. Visconti PE, Westbrook VA, Chertihin O, Demarco I, Sleight S, Diekman AB. Novel signaling pathways involved in sperm acquisition of fertilizing capacity. J Reprod Immunol. 2002;53: 133-150.
39. von Figura K, Steckel F, Conary J, Hasilik A, Shaw E. Heterogeneity in late-onset metachromatic leukodystrophy. Effect of inhibitors of cysteine proteinases. Am J Hum Genet. 1986;39:371-382.
40. Weerachatyanukul W, Rattanachaiyanont M, Carmona E, Furimsky A, Mai A, Shoushtarian A, Sirichotiyakul S, Ballakier H, Leader A, Tanphaichitr N. Sulfogalactosylglycerolipid is involved in human gamete interaction. Mol Reprod Dev. 2001;60:569-578.
41. Weerachatyanukul W, Xu H, Anupriwan A, Carmona E, Wade M, Hermo L, da Silva SM, Rippstein P, Sobhon P, Sretarugsa P, Tanphaichitr N. Acquisition of arylsulfatase A onto the mouse sperm surface during epididymal transit. Biol Reprod. 2003;69:1183-1192.
42. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen-Cervical Mucus Interaction. Cambridge, United Kingdom: Cambridge University Press; 1999:4-30.
43. Yanagimachi R. Mammalianfertilization. In:Knobil E, ed. The Physiology of Reproduction. New York, NY: Raven Press; 1994:189-317.