A randomized, double-blind, placebo-controlled, trial of lamotrigine therapy in bipolar disorder, depressed or mixed phase and cocaine dependence

Neuropsychopharmacology

Volumn 37, Issue 11, 2012, Pages 2347-2354

  Brown, E Sherwood ^a   Sunderajan, Prabha ^a   Hu, Lisa T ^a   Sowell, Sharon M ^a   Carmody, Thomas J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

bipolar disorder; clinical trial; cocaine dependence; lamotrigine

Indexed keywords

COCAINE; LAMOTRIGINE; PLACEBO;

ADULT; ARTICLE; BIPOLAR DISORDER; COCAINE DEPENDENCE; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG ABUSE; DRUG DOSE INCREASE; DRUG SCREENING; FEMALE; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; URINALYSIS; WITHDRAWAL SYNDROME;

ADOLESCENT; ADULT; AGED; BIPOLAR DISORDER; CALCIUM CHANNEL BLOCKERS; COCAINE-RELATED DISORDERS; DEPRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; TREATMENT OUTCOME; TRIAZINES; YOUNG ADULT;

EID: 84866375298     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.90     Document Type: Article

References (49)

1. Aagaard J, Vestergaard P (1990). Predictors of outcome in prophylactic lithium treatment: a 2-year prospective study. J Affect Disord 18:259-266. (Pubitemid 20127123)
2. Albanese MJ, Pies R (2004). The bipolar patient with comorbid substance use disorder: recognition and management. CNS Drugs 18: 585-596. (Pubitemid 38951781)
3. Bauer MS, Altshuler L, Evans DR, Beresford T, Williford WO, Hauger R (2005). Prevalence and distinct correlates of anxiety, substance, and combined comorbidity in a multi-site public sector sample with bipolar disorder. J Affect Disord 85: 301-315. (Pubitemid 40386514)
4. Bauer MS, Williford WO, Dawson EE, Akiskal HS, Altshuler L, Fye C et al (2001). Principles of effectiveness trials and their implementation in VA Cooperative Study #430: 'reducing the efficacy-effectiveness gap in bipolar disorder'. J Affect Disord 67: 61-78. (Pubitemid 34183337)
5. Berger SP, Winhusen TM, Somoza EC, Harrer JM, Mezinskis JP, Leiderman DB et al (2005). A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence. Addiction 100(Suppl 1): 58-67. (Pubitemid 40363425)
6. Brady KT, Sonne SC, Malcolm RJ, Randall CL, Dansky BS, Simpson K et al (2002). Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder. Exp Clin Psychopharmacol 10: 276-285. (Pubitemid 34919936)
7. Brown ES (2005). Bipolar disorder and substance abuse. Psychiatr Clin North Am 28: 415-425.
8. Brown ES, Carmody TJ, Schmitz JM, Caetano R, Adinoff B, Swann AC et al (2009). A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence. Alcohol Clin Exp Res 33: 1863-1869.
9. Brown ES, Gorman AR, Hynan LS (2007). A randomized, placebocontrolled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence. J Clin Psychopharmacol 27: 498-502. (Pubitemid 47415050)
10. Brown ES, Nejtek VA, Perantie DC, Bobadilla L (2002). Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord 4: 406-411. (Pubitemid 36041471)
11. Brown ES, Nejtek VA, Perantie DC, Orsulak PJ, Bobadilla L (2003a). Lamotrigine in patients with bipolar disorder and cocaine dependence. J Clin Psychiatry 64: 197-201. (Pubitemid 36268323)
12. Brown ES, Nejtek VA, Perantie DC, Rajan Thomas N, Rush AJ (2003b). Cocaine and amphetamine use in patients with psychiatric illness: a randomized trial of typical antipsychotic continuation or discontinuation. J Clin Psychopharmacol 23: 384-388. (Pubitemid 36951181)
13. Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD (1999). A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 60: 79-88. (Pubitemid 29104383)
14. Calabrese JR, Shelton MD, Rapport DJ, Kimmel SE (2002). Bipolar disorders and the effectiveness of novel anticonvulsants. J Clin Psychiatry 63(Suppl 3): 5-9. (Pubitemid 34225609)
15. Calabrese JR, Suppes T, Bowden CL, Sachs GS, Swann AC, McElroy SL et al (2000). A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group. J Clin Psychiatry 61: 841-850.
16. Estroff TW, Dackis CA, Gold MS, Pottash AL (1985). Drug abuse and bipolar disorders. Int J Psychiatry Med 15: 37-40. (Pubitemid 15063105)
17. Fals-Stewart W, O'Farrell TJ, Freitas TT, McFarlin SK, Rutigliano P (2000). The timeline followback reports of psychoactive substance use by drug-abusing patients: psychometric properties. J Consult Clin Psychol 68: 134-144. (Pubitemid 30120958)
18. First M, Spitzer R, Gibbon M, JBW W (1995). Structured Clinical Interview for DSM-IV Axis I Disorders. Biometrics Research Department, New York State Psychiatric Institute, Department of Psychiatry, Columbia University: New York.
19. Gass JT, Olive MF (2008). Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 75: 218-265. (Pubitemid 350235390)
20. Geddes JR, Calabrese JR, Goodwin GM (2009). Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials. Br J Psychiatry 194: 4-9.
21. Hamilton M (1960). A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
22. Javitt DC, Schoepp D, Kalivas PW, Volkow ND, Zarate C, Merchant K et al (2011). Translating glutamate: from pathophysiology to treatment. Sci Transl Med 3: 102.
23. Kalivas PW, Volkow ND (2011). New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry 16: 974-986.
24. Kashner TM, Carmody TJ, Suppes T, Rush AJ, Crismon ML, Miller AL et al (2003). Catching up on health outcomes: the Texas Medication Algorithm Project. Health Serv Res 38(1 Pt 1): 311-331. (Pubitemid 36373311)
25. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S et al (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 51: 8-19. (Pubitemid 24028993)
26. Kosten TR (1998). Pharmacotherapy of cerebral ischemia in cocaine dependence. Drug Alcohol Depend 49: 133-144. (Pubitemid 28111900)
27. Margolin A, Avants SK, DePhilippis D, Kosten TR (1998). A preliminary investigation of lamotrigine for cocaine abuse in HIV-seropositive patients. Am J Drug Alcohol Abuse 24: 85-101. (Pubitemid 28101092)
28. Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA et al (2011). Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry 68: 241-251.
29. Miller FT, Busch F, Tanenbaum JH (1989). Drug abuse in schizophrenia and bipolar disorder. Am J Drug Alcohol Abuse 15: 291-295. (Pubitemid 19195561)
30. Minozzi S, Amato L, Davoli M, Farrell M, Lima Reisser AA, Pani PP et al (2008). Anticonvulsants for cocaine dependence. Cochrane Database Syst Rev 16: CD006754.
31. Mitchell JD, Brown ES, Rush AJ (2007). Comorbid disorders in patients with bipolar disorder and concomitant substance dependence. J Affect Disord 102: 281-287. (Pubitemid 47042185)
32. Mueser KT, Yarnold PR, Bellack AS (1992). Diagnostic and demographic correlates of substance abuse in schizophrenia and major affective disorder. Acta Psychiatr Scand 85: 48-55.
33. Nejtek VA, Avila M, Chen LA, Zielinski T, Djokovic M, Podawiltz A et al (2008). Do atypical antipsychotics effectively treat cooccurring bipolar disorder and stimulant dependence? A randomized, double-blind trial. J Clin Psychiatry 69: 1257-1266.
34. Nunes EV, McGrath PJ, Wager S, Quitkin FM (1990). Lithium treatment for cocaine abusers with bipolar spectrum disorders. Am J Psychiatry 147: 655-657. (Pubitemid 20153443)
35. Pisani A, Bonsi P, Martella G, De Persis C, Costa C, Pisani F et al (2004). Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine. Epilepsia 45: 719-728. (Pubitemid 38890968)
36. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL et al (1990). Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264: 2511-2518.
37. Rush AJ, Trivedi MH, Ibrahim HM, Carmody TJ, Arnow B, Klein DN et al (2003). The 16-item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and selfreport (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry 54: 573-583. (Pubitemid 37289444)
38. Salloum IM, Douaihy A, Cornelius JR, Kirisci L, Kelly TM, Hayes J (2007). Divalproex utility in bipolar disorder with cooccurring cocaine dependence: a pilot study. Addict Behav 32: 410-415. (Pubitemid 44918222)
39. Saxon AJ, Calsyn DA, Stanton V, Hawker CS (1994). Using the general behavior inventory to screen for mood disorders among patients with psychoactive substance dependence. Am J Addict 3: 296-305. (Pubitemid 24357505)
40. Schmidt HD, Pierce RC (2010). Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Ann NY Acad Sci 1187: 35-75.
41. Sitges M, Chiu LM, Guarneros A, Nekrassov V (2007). Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings. Neuropharmacology 52: 598-605. (Pubitemid 46151686)
42. Sonne SC, Brady KT, Morton WA (1994). Substance abuse and bipolar affective disorder. J Nerv Ment Dis 182: 349-352. (Pubitemid 24227612)
43. Stefani A, Spadoni F, Bernardi G (1997). Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies. Exp Neurol 147: 115-122. (Pubitemid 27402448)
44. Thase ME, Fava M, Halbreich U, Kocsis JH, Koran L, Davidson J et al (1996). A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia. Arch Gen Psychiatry 53: 777-784. (Pubitemid 26303618)
45. Tiffany ST, Singleton E, Haertzen CA, Henningfield JE (1993). The development of a cocaine craving questionnaire. Drug Alcohol Depend 34: 19-28. (Pubitemid 24036387)
46. Uys JD, LaLumiere RT (2008). Glutamate: the new frontier in pharmacotherapy for cocaine addiction. CNS Neurol Disord Drug Targets 7: 482-491.
47. Uys JD, Reissner KJ (2011). Glutamatergic neuroplasticity in cocaine addiction. Prog Mol Biol Transl Sci 98: 367-400.
48. Wang SJ, Sihra TS, Gean PW (2001). Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity. Neuroreport 12: 2255-2258. (Pubitemid 32646283)
49. Young RC, Biggs JT, Ziegler VE, Meyer DA (1978). A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133: 429-435. (Pubitemid 9006756)