Bisphosphonate-related osteonecrosis of the jaws - A review

Oral Oncology

Volumn 48, Issue 10, 2012, Pages 938-947

  Kühl, Sebastian ^a   Walter, Christian ^b   Acham, Stephan ^c   Pfeffer, Roland ^a   Lambrecht, J Thomas ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

Diphosphonates; Incidence; Osteonecrosis of the jaw; Treatment outcomes

Indexed keywords

ANTIBIOTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; PAMIDRONIC ACID; ZOLEDRONIC ACID;

ANTIBIOTIC THERAPY; CONSERVATIVE TREATMENT; DEBRIDEMENT; EVIDENCE BASED MEDICINE; HUMAN; INCIDENCE; JAW OSTEONECROSIS; NEODYMIUM LASER; PRIORITY JOURNAL; PUBLICATION; RADICAL RESECTION; REVIEW; TREATMENT OUTCOME; WOUND HEALING;

ADMINISTRATION, ORAL; BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAW; BONE DENSITY CONSERVATION AGENTS; BONE DISEASES; DIPHOSPHONATES; HUMANS; INJECTIONS, INTRAVENOUS; PERIODICALS AS TOPIC; TREATMENT OUTCOME;

EID: 84866373893     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2012.03.028     Document Type: Review

References (195)

1. G. Carter, A.N. Goss, and C. Doecke Bisphosphonates and avascular necrosis of the jaw: a possible association Med J Aust 182 8 2005 413 415
2. M.T. Drake, B.L. Clarke, and S. Khosla Bisphosphonates: mechanism of action in clinical practise Mayo Clin Proc 83 9 2008 1032 1045
3. M.S. Greenberg Intravenous bisphosphonates and osteonecrosis Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98 3 2004 259 260
4. F. Capsoni, M. Longhi, and R. Weinstein Bisphosphonate-associated osteonecrosis of the jaw: the rheumatologist's role Arthritis Res Ther 8 5 2006 219 224
5. P. Conte, and V. Guarneri Safety of intravenous and oral bisphosphonates and compliance with dosing regimens Oncologist 9 Suppl. 4 2004 28 37
6. M.R. Markiewicz, J.E. Marggarone, J.H. Campbell, and A. Aguirre Bisphosphonate-associated osteonecrosis of the jaws: a review of current knowledge J Am Dent Assoc 136 12 2005 1669 1674
7. R.E. Marx, and D.S. Stern Biopsy principles and techniques R.E. Marx, D.S. Stern, Oral and maxillofacial pathology: a rationale for diagnosis and treatment 2002 Quintessence Chicago 36 38
8. R.E. Marx Pamidronate (Aredia) and zoledronate (Zometa) induced necrosis of the jaw: a growing epidemic J Oral Maxillofacial Surg 61 9 2003 1115 1118
9. S.L. Ruggiero, J. Fantasia, and E. Carlson Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 4 2006 433 441
10. C.L. Estilo, C.H. Van Poznak, T. Williams, E. Evtimovska, L. Tkach, and J.L. Halpern Osteonecrosis of the maxilla and mandible in patients treated with bisphosphonates: a retrospective study J Clin Oncol 22 14 2004 8088
11. A.M. Donghue Bisphosphonates and osteonecrosis: analogy to phossy jaw Med J Aust 183 3 2005 163 164
12. T. Hansen, M. Kunkel, E. Springer, C. Walter, A. Weber, and E. Siegel Actinomycosis of the jaws - histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis Virchows Arch 451 6 2007 1009 1017
13. J.W. Hellstein, and C. Fielding Bisphosphonate osteochemosis: clinical findings and treatment theories may relate to a possible analogy with "phossy jaw" Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100 2 2005 189 190
14. R.E. Marx Uncovering the cause of "Phossy Jaw" circa 1858 to 1906: oral and maxillofacial surgery closed case files - case closed J Oral Maxillofac Surg 66 11 2008 2356 2363
15. S.L. Ruggiero, B. Mehrotra, T.J. Rosenber, and S.L. Engroff Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases J Oral Maxillofac Surg 62 5 2004 527 534
16. American Association of Oral and Maxillofacial Surgeons Position paper on bisphosphonate-related osteonecrosis of the jaws J Oral Maxillofac Surg 65 3 2007 369 376
17. American Dental Association Council on Scientific Affairs Dental management of patients receiving oral bisphosphonate therapy: expert panel recommendations J Am Dent Assoc 137 8 2006 1144 1150
18. J. Bagan, J. Blade, J.M. Cozar, M. Constela, R. Garcia Sanz, and F. Gómez-Veiga Recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaw (ONJ) in cancer patients treated with bisphosphonates Med Oral Patol Oral Cir Bucal 12 2007 E336 E340
19. B.J. Edwards, J.W. Hellstein, P.L. Jacobsen, S. Kaltman, A. Mariotti, and C.A. Migliorati Updated recommendations for managing the care of patients receiving oral bisphosphonate therapy: an advisory statement from the American Dental Association Council on Scientific Affairs J Am Dent Assoc 139 5 2008 1674 1677
20. K.A. Grötz, and T. Kreusch Zahnärztliche Betreuung von Patienten unter/nach Bisphosphonat-Medikation Dtsch Zahnärztl Z 60 10 2006 1 11
21. A.A. Khan, G.K.B. Sandor, E. Dore, A.D. Morisson, M. Alsahli, and F. Amin Canadian consensus practise guidelines for bisphosphonate associated osteonecrosis of the jaw J Rheumatol 35 7 2008 1391 1397
22. S. Koshla, D. Burr, J. Cauley, D.W. Dempster, P.R. Ebeling, and D. Felsenberg Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research J Bone Miner Res 22 10 2007 1479 1491
23. N.M.H. McLeod, V. Patel, A. Kusanale, S.N. Rogers, and P.A. Brennan Bisphosphonate osteonecrosis of the jaw: a literature review of UK policies versus international policies on the management of bisphosphonate osteonecrosis of the jaw Br J Oral Maxillofac Surg 49 5 2011 335 342
24. C.A. Migliorati, J. Casiglia, J. Epstein, P.L. Jacobsen, M.A. Siegel, and S.B. Woo Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper J Am Dent Assoc 136 12 2005 1658 1668
25. S.L. Ruggiero, J. Gralow, R.E. Marx, A.O. Hoff, M.M. Schubert, and J.M. Huryn Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer J Oncol Pract 2 1 2006 7 14
26. S.L. Ruggiero, T.B. Dodson, L.A. Assael, R. Landesberg, R.E. Marx, and B. Mahrotra American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws - 2009 update J Oral Maxillofac Surg 67 Suppl. 1 2009 2 12
27. M. Tubiana-Hulli, M. Spielmann, C. Roux, M. Campone, L. Zelek, and J. Gligorov Physiopathology and management of osteonecrosis of the jaws related to bisphosphonate therapy for malignant bone lesions. A French expert panel analysis Crit Rev Oncol Hematol 71 1 2009 12 21
28. R. Weitzman, N. Sauter, E.F. Eriksen, P.G. Tarasoff, L.V. Lacerna, and R. Dias Critical review: update recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in cancer patients - May 2006 Crit Rev Oncol Hematol 62 2 2007 148 152
29. P.G. Shekelle, S.H. Woolf, M. Eccles, and J. Grimshaw Clinical guidelines: developing guidelines Brit Med J 318 7183 1999 593
30. D. Mauri, A. Valachis, I.P. Polyzos, N.P. Polyzos, K. Kamposioras, and L.L. Pesce Osteonecrosis of the jaw and use of bisphosphonates in adjuvant breast cancer treatment: a meta-analysis Breast Cancer Res Treat 116 3 2009 433 439
31. M.K. Jeffcoat, G. Cizza, W.J. Shih, R. Genco, and A. Lombardi Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis J Int Acad Periodontol 9 3 2007 70 76
32. M.K. Jeffcoat Safety of oral bisphosphonates: controlled studies on alveolar bone Int J Oral Maxillofac Implants 21 3 2006 349 353
33. D.M. Black, A.V. Schwartz, K.E. Ensrud, J.A. Cauley, S. Levis, and S.A. Quandt Effects of continuing or stopping Alendronate after 5 years of treatment JAMA 296 24 2006 2927 2938
34. K.W. Lyles, C.S. Colon-Emeric, J.S. Magaziner, J.D. Adachi, C.F. Pieper, and C. Mautalen Zoledronic acid and clinical fractures and mortality after hip fracture N Engl J Med 357 18 2007 1799 1809
35. M.R. Allen, and D.B. Burr Mandible matrix necrosis in beagle dogs after 3-years of daily oral bisphosphonate treatment J Oral Maxillofac Surg 66 5 2008 987 994
36. J.T. Grbic, R. Landesberg, S.Q. Lin, P. Mesenbrink, I.R. Reid, and P.C. Leung Incidence of osteonecrosis of the jaw in women with postmenopausal osteoporosis in health outcomes and reduced incidence with zoledronic acid once yearly pivotal fracture trial J Am Dent Assoc 139 1 2008 32 40
37. P. Musto, M.T. Petrucci, S. Bringhen, T. Guglielmelli, T. Caeavita, and V. Bongarzoni A multicenter randomised clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma Cancer 113 7 2008 1588 1595
38. A.M. Brufsky, L.D. Bosserman, R.R. Caradonna, B.B. Haley, C.M. Jones, and H.C. Moore Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results Clin Breast Cancer 9 2 2009 77 85
39. D.B. Burr, and M.R. Allen Mandibular necrosis in beagle dogs treated with bisphosphonates Orthod Craniofac Res 12 3 2009 221 228
40. D. Aguiar Bujanda, U. Bohn Sarmiento, M.A. Cabrera, and J. Aguiar Morals Assessment of renal toxicity and osteonecrosis of the jaws in patients receiving zoledronic acid for bone metastasis Ann Oncol 18 3 2007 556 560
41. M.A. Dimopoulos, E. Kastritis, C. Bamia, I. Melakopoulos, D. Gika, and M. Roussou Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid Ann Oncol 20 1 2009 117 120
42. F. Dore, L. Filippi, M. Biasotto, S. Chiandussi, F. Cavalli, and D.I. Lenarda Bone scintigraphy and SPECT/CT of bisphosphonate-induced osteonecrosis of the jaw J Nucl Med 50 1 2009 30 35
43. R. Kunchur, A. Need, T. Hughes, and A. Goss Clinical investigation of C-terminal cross-linking telopeptide test in prevention and management of bisphosphonate-associated osteonecrosis of the jaws J Oral Maxillofac Surg 67 6 2009 1167 1173
44. C.I. Ripamonti, M. Maniezzo, T. Campa, E. Fagnoni, C. Brunelli, and G. Saibene Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan Ann Oncol 20 1 2009 137 145
45. S. Hoefert, I. Schmitz, A. Tannapfel, and H. Eufinger Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings Clin Oral Investig 14 3 2010 271 284
46. P. Stockmann, E. Vairaktaris, F. Wehrhan, M. Seiss, S. Schwarz, and B. Spriewald Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up Support Care Cancer 18 4 2010 449 460
47. P. Stockmann, F.M. Hinkmann, M.M. Lell, M. Fenner, E. Vairaktaris, and F.W. Neukam Panoramic radiograph, computed tomography or magnetic resonance imaging. Which imaging technique should be preferred in bisphosphonate- associated osteonecrosis of the jaw? A prospective clinical study Clin Oral Investig 14 3 2010 311 317
48. A. Bamias, E. Kastritis, C. Bamia, L.A. Moulopoulos, I. Melakopoulos, and G. Bozas Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors J Clin Oncol 23 34 2005 8580 8587
49. M.A. Dimopoulos, E. Kastritis, A. Anagnostopoulos, I. Melakopoulos, D. Gika, and L.A. Moulopoulos Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acid Haematologica 91 7 2006 968 971
50. A.I. Zervas, and S. Zhus Bisphosphonates are associated with increased risk for jaw surgery in medical claims data: is it osteonecrosis? J Oral Maxillofac Surg 64 6 2006 917 923
51. A. Corso, M. Varettoni, P. Zappasodi, C. Klersy, S. Mangiacavalli, and G. Pica Different schedule of zoledronic acid can reduce the risk of the osteonecrosis of the jaw in patients with multiple myeloma reduced risk of ONJ with a different schedule of zoledronic acid Leukemia 21 7 2007 1545 1548
52. F. Jadu, L. Lee, M. Pharoah, D. Reece, and L. Wang A retrospective study assessing the incidence, risk factors and comorbidities of pamidronate-related necrosis of the jaws in multiple myeloma patients Ann Oncol 18 12 2007 2015 2019
53. L. Montebugnoli, L. Felicetti, B.D. Gissi, A. Pizzigallo, G.A. Pelliccioni, and C. Marchetti Bisphosphonate-associated osteonecrosis can be controlled by nonsurgical management Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104 4 2007 473 477
54. A. Badros, E. Terpos, E. Katodritou, O. Goloubeva, E. Kastritis, and E. Verrou Natural history of osteonecrosis of the jaw in patients with multiple myeloma J Clinical Oncol 26 36 2008 5904 5909
55. M.L. Bianchi, C. Limonta, J. Frasunkiewicz, M. Biggioggero, and S. Vai Comment on: bisphosphonates and osteonecrosis of the jaw J Rheumatol 47 3 2008 383
56. T. Boonyapakorn, I. Schirmer, P.A. Reichart, I. Strum, and G. Massenkeil Bisphosphonate-induced osteonecrosis of the jaws: prospective study of 80 patients with multiple myeloma and other malignancies Oral Oncol 44 9 2008 857 869
57. B. Malmgren, E. Aström, and S. Söderhäll No osteonecrosis in jaws of young patients with osteogenesis imperfecta treated with bisphosphonates J Oral Pathol Med 37 4 2008 196 200
58. N. Raje, S.B. Woo, K. Hande, J.T. Yap, P.G. Richardson, and S. Vallet Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw Clin Cancer Res 14 8 2008 2387 2395
59. M.A. Sarasquete, R. Carcia-Sanz, L. Marin, M. Alcoceba, M.C. Chillon, and A. Balanzategui Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis Blood 112 7 2008 2709 2712
60. P. Vescovi, E. Merigo, M. Manfredi, M. Meleti, C. Fornaini, and M. Bonanini Nd:YAG laser biostimulation in the treatment of bisphosphonate- associated osteonecrosis of the jaw: clinical experience in 28 cases Photomed Laser Surg 26 1 2008 37 46
61. M.R. Allen, and S.L. Ruggiero Higher bone matrix density exists in only a subset of patients with bisphosphonate-related osteonecrosis of the jaw J Oral Maxillofac Surg 67 7 2009 1373 1377
62. J.B. Aragon-Ching, Y.M. Ning, C.C. Chen, L. Latham, J.P. Guadagnini, and J.L. Gulley Higher incidence of osteonecrosis of the jaw (ONJ) in patients with metastatic castration resistant prostate cancer treatment with anti-angiogenic agents Cancer Invest 27 2 2009 221 226
63. B.S. Crawfors, R.M. McNulty, E.H. Kraut, and R.C. Turowski Extended use of intravenous bisphosphonate therapy for the prevention of skeletal complications in patients with cancer Cancer Invest 27 10 2009 984 988
64. T.I. Jung, F. Hoffmann, G. Glaeske, and D. Felsenberg Disease-specific risk for an osteonecrosis of the jaw under bisphosphonate therapy J Cancer Res Clin Oncol 136 3 2010 363 370
65. T.S. Lazarovici, R. Yahalom, S. Taicher, S. Elad, I. Hardan, and N. Yarom Bisphosphonate-related osteonecrosis of the jaws: a single-center study of 101 patients J Oral Maxillofac Surg 67 4 2009 850 855
66. P. Lesclous, S. Abi Najm, J.P. Carrel, B. Baroukh, T. Lombardi, and J.P. Willi Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation? Bone 45 5 2009 843 852
67. J.C. Lo, F.S. O'Ryan, N.P. Gordon, J. Yang, R.L. Hui, and D. Martin Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure J Oral Maxillofac Surg 68 2 2010 243 253
68. P.K. Palaska, V. Cartsos, and A.I. Zavras Bisphosphonates and time to osteonecrosis development Oncologist 14 11 2009 1154 1166
69. S. Stübinger, J.P. Dissmann, N. Chambron Pinho, B. Saldamli, O. Seitz, and R. Sader A preliminary report about treatment of bisphosphonate related osteonecrosis of the jaw with Er:YAG laser ablation Lasers Surg Med 41 1 2009 26 30
70. N. Treister, N. Sheehy, E.H. Bae, B. Friedland, M. Lerman, and S. Woo Dental panoramic radiographic evaluation in bisphosphonate-associated osteonecrosis of the jaws Oral Dis 15 1 2009 88 92
71. T. Van den Wygaert, T. Claeys, M.T. Huizing, J.B. Vermorken, and E. Fossion Initial experience with conservative treatment in cancer patients with osteonecrosis of the jaw (ONJ) and predictors of outcome Ann Oncol 20 2 2009 331 336
72. P. Vescovi, E. Merigo, M. Manfredi, M. Meleti, C. Fornaini, and M. Bonanini Surgical treatment of maxillary osteonecrosis due to bisphosphonates using Er:YAG (2940nm) laser. Discussion of 17 clinical cases Rev Belge Med Dent 64 2 2009 87 95
73. B.G.M. Durie, M. Katz, and J. Crowley Osteonecrosis of the jaw and bisphosphonates N Engl J Med 353 1 2005 2728
74. G. Ficarra, F. Beninati, I. Rubino, A. Vannucchi, G. Longo, and P. Tonelli Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment J Clin Periodontol 32 11 2005 1123 1128
75. V. Guarneri, S. Donati, M. Nicolini, S. Giovannelli, R. D'Amico, and P.F. Conte Renal safety and efficacy of i.v. bisphosphonates in patients with skeletal metastases treated for up to 10 years Oncologist 10 10 2005 842 848
76. M. Maerevoet, C. Martin, and L. Duck Osteonecrosis of the jaw and bisphosphonates N Engl J Med 353 1 2005 99 102
77. M.D. Melo, and G. Obeid Osteonecrosis of the jaws in patients with a history of receiving bisphosphonate therapy: strategies for prevention and early recognition J Am Dent Assoc 136 12 2005 1675 1681
78. P. Milillo, A.P. Garribba, G. Favia, and G.C. Ettorre Jaw osteonecrosis in patients treated with bisphosphonates: MDCT evaluation Radiol Med 112 4 2007 603 611
79. M.H. Abu-Id, Y. Acil, J. Gottschalk, and T. Kreusch Bisphosphonate- associated osteonecrosis of the jaw Mund Kiefer Gesichtschir 10 2 2006 73 81
80. A. Badros, D. Weikel, A. Salama, O. Goloubeva, A. Schneider, and A. Rapoport Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors J Clin Oncol 24 6 2006 945 952
81. J.M. Calvo-Villas, M. Tapia Torres, J. Govantes Rodriguez, Carreter De Granada, and F. Sicilia Guillen Osteonecrosis del maxilar en pacientes con myeloma multiple y después del tratamiento con ácido zoledrónico Med Clín (Barc) 127 15 2006 576 579
82. S. Chiandussi, M. Biasotto, F. Dore, F. Cavalli, M.A. Cova, and R. Di Lenarda Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws Dentomaxillofac Radiol 35 4 2006 236 243
83. I. Dimitrakopoulos, C. Magopoulos, and D. Karakasis Bisphosphonate- induced avascular osteonecrosis of the jaws: a clinical report of 11 cases Int J Oral Maxillofac Surg 35 7 2006 588 593
84. R. Estefania Fresco, N. Ponte Fernandez, and J.M. Aguirre Urizar Bisphosphonates and oral pathology II. Osteonecrosis of the jaws: review of the literature before 2005 Med Oral Patol Oral Cir Bucal 11 2006 E456 E461
85. M.C. Farrugia, D.J. Summerlin, E. Krowiak, T. Huntley, S. Freeman, and R. Borrowdale Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates Laryngoscope 116 1 2006 115 120
86. T. Hansen, M. Kunkel, A. Weber, and J.C. Kirkpatrick Osteonecrosis of the jaws in patients treated with bisphosphonates - histomorphologic analysis in comparison with infected osteoradionecrosis J Oral Pathol Med 35 3 2006 155 160
87. G. Sanna, L. Preda, R. Bruschini, M. Cossu Rocca, S. Feretti, and L. Adamoli Bisphosphonates and jaw osteonecrosis in patients with advanced breast cancer Ann Oncol 17 10 2006 1512 1516
88. S.G. Thakkar, C. Isada, J. Smith, M.A. Karam, J. Reed, and J.W. Tompford Complications associated with bisphosphonate use in patients with plasma cell dyscrasias Med Oncol 23 1 2006 51 56
89. T. Van den Wygaert, M.T. Huizing, and J.B. Vermorken Bisphosphonates and osteonecrosis of the jaw: cause and effect or a post hoc fallacy? Ann Oncol 17 8 2006 1197 1204
90. S.B. Woo, J.W. Hellenstein, and J.R. Kalmar Systemic review: bisphosphonate and osteonecrosis of the jaws Ann Intern Med 144 10 2006 753 761
91. A. Wutzl, G. Eisenmenger, M. Hoffmann, C. Czerny, D. Moseer, and P. Pietschmann Osteonecrosis of the jaws and bisphosphonate treatment in cancer patients Wien Klin Wochenschr 118 15-16 2006 473 478
92. K. Zervas, E. Verrou, Z. Teleioudis, K. Vahtsevanos, A. Banti, and D. Mihoud Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: a single-centre experience in 303 patients Br J Haematol 134 6 2006 620 623
93. M.C. Adornato, I. Morcos, and J. Rozanski The treatment of bisphosphonate-associated osteonecrosis of the jaws with bone resection and autologous platelet-derived growth factors J Am Dent Assoc 138 7 2007 971 977
94. A. Agrillo, P. Sassano, C. Rinna, P. Priore, and G. Iannetti Ozone therapy in extractive surgery on patients treated with bisphosphonates J Craniofac Surg 18 5 2007 1068 1070
95. A. Agrillo, C. Ungari, F. Filiaci, P. Priore, and G. Iannetti Ozone therapy in the treatment of avascular bisphosphonate-related jaw osteonecrosis J Craniofac Surg 18 5 2007 1071 1075
96. Y. Ariyoshi The Japanese experience with bisphosphonate-related osteonecrosis of the jaw J Oral Maxillofac Surg 65 Suppl. 9 2007 17 18
97. K. Barker, D. Lowe, A. Olujohungbe, E. Low, and S.N. Rogers Survey of members of myeloma UK on bisphosphonates-associated jaw osteonecrosis Br J Haematol 139 4 2007 621 628
98. S.D. Bianchi, M. Scoletta, F. Bozzalla Cassione, G. Mogliaretti, and M. Mozatti Computerized tomographic findings in bisphosphonate-associated osteonecrosis of the jaw in patients with cancer Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104 2 2007 249 258
99. B.M. Clarke, J. Boyette, E. Vural, J.Y. Suen, E.J. Anaissie, and B.C. Stark Jr. Bisphosphonates and jaw osteonecrosis: the UAMS experience Otolaryngol Head Neck Surg 136 3 2007 396 400
100. R. Diego, O. D'Orto, D. Pagani, A. Agazzi, U. Marzano, and G. Derada Troletti Bisphosphonate-associated osteonecrosis of the jaws: a therapeutic dilemma Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 3 2007 e1 e5
101. J.J. Freiberger, R. Padilla-Burgos, A.H. Chhoeu, K.H. Kraft, O. Boneta, and R.E. Moon Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series J Oral Maxillofac Surg 65 7 2007 1321 1327
102. P.A. Fugazzotto Osteonecrosis in the jaws of patients who are using oral bisphosphonates to treat osteoporosis Int J Oral Maxillofacial Implants 22 1 2007 152 153
103. J.A. Garcia Saenz, S. Lopez Tarruella, B. Garcia Paredes, L. Rodriguez Lajusticia, L. Villalobos, and E. Diaz Rubio Osteonecrosis of the jaw as an adverse bisphosphonate event: Three cases of bone metastatic prostate cancer patients treated with zoledronic acid Med Oral Patol Oral Cir Bucal 12 2007 E351 E356
104. K.A. Grötz, C. Walter, C. Küttner, and B. Al-Nawas Relevance of bisphosphonate long-term therapy in radiation of endosteal jaw metastases Strahlenther Onkol 183 4 2007 190 194
105. I. Heras Rincon, I. Zubillaga Rodriguez, M. Castillo Tambay, and J.J. Montalvo Moreno Osteonecrosis of the jaws and bisphosphonates. Report of fifteen cases. Therapeutic recommendations Med Oral Patol Oral Cir Bucal 12 1 2007 E267 E271
106. O. Kanat, A. Ozer, S. Ataergin, O. Kuzhan, F. Arpaci, and B. Ozturk Bisphosphonate treatment as a cause of the jaw osteonecrosis Oral Disease 13 3 2007 346 347
107. M. Khamaisi, E. Regev, N. Yarom, B. Avni, E. Leitersdorf, and I. Raz Possible association between diabetes and bisphosphonate-related jaw osteonecrosis J Clin Endocrinol Metab 92 3 2007 1172 1175
108. G. Longobardi, R. Boniello, G. Gasparini, I. Pagano, and S. Pelo Surgical therapy for osteonecrotic lesions of the jaws in patients in therapy with bisphosphonates J Craniofac Surg 18 5 2007 1012 1017
109. R.E. Marx, J.E. Cillo, and J.J. Ulloa Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment J Oral Maxillofac Surg 65 12 2007 2397 2410
110. T. Mavrokokki, A. Cheng, B. Stein, and A. Goss Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia J Oral Maxillofac Surg 65 3 2007 415 423
111. O.M. Murad, S. Arora, A.F. Farag, and H.A. Guber Bisphosphonates and osteonecrosis of the jaw: a retrospective study Endocr Pract 13 3 2007 232 238
112. C. Ortega, F. Montemurro, R. Faggiuolo, R. Vormola, D. Nanni, and F. Goia Osteonecrosis of the jaw in prostate cancer patients with bone metastases treated with zoledronate: a retrospective analysis Acta Oncol 46 5 2007 664 668
113. M.T. Petrucci, C. Gallucci, A. Agrillo, M.C. Mustazza, and R. Foa Role of ozone therapy in the treatment of osteonecrosis of the jaws in multiple myeloma patients Haematologica 92 9 2007 1289 1290
114. P.M. Phal, R.W.T. Myall, L.A. Assael, and J.L. Weissman Imaging findings of bisphosphonate-associated osteonecrosis of the jaws Am J Neuroradiol 28 6 2007 1139 1145
115. S. Pozzi, R. Marcheselli, S. Sacchi, L. Baldini, F. Angrilli, and E. Pennese Bisphosphonate-associated osteo-necrosis of the jaw. A review of 35 cases and an evaluation of its frequency in multiple myeloma patients Leuk Lymphoma 48 1 2007 56 64
116. C. Walter, K.A. Grötz, M. Kunkel, and B. Al-Nawas Prevalence of bisphosphonate associated osteonecrosis of the jaw within the field of osteonecrosis Support Care Cancer 15 2 2007 197 202
117. E.P. Wang, L.B. Kahan, G.J. Strewler, N. Raje, and M. Troulis Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy J Oral Maxillofac Surg 65 7 2007 1328 1331
118. G.S. Wilkinson, Y.F. Fuo, J.L. Freeman, and J.S. Goodwin Intravenous bisphosphonate therapy and inflammatory conditions or surgery of the jaw: a population-based analysis J Natl Cancer Inst 99 13 2007 1016 1024
119. M.H. Abu-Id, P.H. Warnke, J. Gottschalk, I. Springer, J. Wiltfang, and Y. Acil "Bis-phossy jaws" - high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw J Craniomaxillofac Surg 36 2 2008 95 103
120. A. Bedogni, S. Blandamura, Z. Lokmic, C. Palumbo, M. Ragazzo, and F. Ferrari Bisphosphonate-associated jawbone osteonecrosis: a correlation between imaging techniques and histo-pathology Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105 3 2008 358 364
121. S. Bisdas, N. Chambron Pinho, A. Smolarz, R. Sader, T.J. Vogl, and M.G. Mack Bisphosphonate-induced osteonecrosis of the jaw: CT and MRI spectrum of findings in 32 patients Clin Radiol 63 1 2008 71 77
122. J.J. Brown, L. Ramalingam, and M.R. Zacharin Bisphosphonate-associated osteonecrosis of the jaw: does it occur in children? Clin Endocrinol (Oxf) 68 6 2008 863 867
123. A.M. Cafro, L. Barbarano, A.M. Nosari, G. D'Avanzo, M. Nichelatti, and M. Bidas Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: definition and management of the risk related to zoledronic acid Clin Lymphoma Myeloma 8 2 2008 111 116
124. D. Carmagnola, S. Celestino, and S. Abati Dental and periodontal history of oncologic patients on parenteral bisphosphonates with or without osteonecrosis of the jaw: a pilot study Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 6 2008 e10 e15
125. V.M. Cartosos, S. Zhu, and A.I. Zavras Bisphosphonate use and the risk of adverse jaw outcomes: a medical claims study of 714,217 people J Am Dent Assoc 139 1 2008 23 30
126. C. Cahine, M.S. Cheung, T.W. Head, S. Schwartz, F.H. Glorieux, and F. Rauch Tooth extraction socket healing in pediatric patients treated with intravenous pamidronate J Pediatrics 153 5 2008 719 720
127. C.L. Estilo, C.H. Van Poznak, T. Williams, G.C. Bohle, P.T. Lwin, and Q. Zhou Osteonecrosis of the maxilla and mandible in patients with advanced cancer treated with bisphosphonate therapy Oncologist 13 8 2008 911 920
128. L. Garcia-Ferrer, J.V. Bagan, V. Martinez-Sanjuan, S. Hernandesz-Bazan, R. Garcia, and Y. Jimenez-Soriano MRI of mandibular osteonecrosis secondary to bisphosphonates Am J Roentgenol 190 4 2008 949 955
129. B.T. Grant, C. Amendedo, K. Freeman, and R.A. Kraut Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases J Oral Maxillofac Surg 66 2 2008 223 230
130. A.O. Hoff, B.B. Toth, K. Altundag, M.M. Johnson, C.L. Warneke, and M. Hu Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates J Bone Miner Res 23 6 2008 826 836
131. T. Ibrahim, F. Barbanti, G. Giorgio-Marrano, L. Mercatali, S. Ronconi, and C. Vicini Osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: a retrospective study Oncologist 13 3 2008 330 336
132. A. Kyrgidis, K. Vahtsevanos, G. Koloutsos, C. Andreadis, I. Boukovinas, and Z. Teleioudis Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients J Clin Oncol 26 28 2008 4634 4638
133. N. La Verde, C. Bareggi, M. Garassino, K. Borgonovo, P. Sburlati, and D. Pedretti Osteonecrosis of the jaw (ONJ) in cancer patients treated with bisphosphonates: how the knowledge of a phenomenon can change its evolution Support Care Cancer 16 11 2008 1311 1315
134. V. Montefusco, F. Gay, F. Spina, R. Miceli, M. Maniezzo, and M.T. Ambrosini Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates Leuk Lymphoma 49 11 2008 2156 2162
135. S. Schwartz, C. Joseph, D. Iera, and D.D. Vu Bisphosphonates, osteonecrosis, osteogenesis imperfecta and dental extractions: a case series J Can Dent Assoc 74 6 2008 537 542
136. P.P. Sedghizadeh, S.K.S. Kumar, A. Gorur, C. Sschaudinn, C.F. Shuler, and J.W. Costerton Identification of microbial biofilms in osteonecrosis of the jaw secondary to bisphosphonate therapy J Oral Maxillofac Surg 66 4 2008 767 775
137. M.H. Vieillard, J.M. Maes, G. Penel, T. Facon, L. Magro, and J. Bonneterre Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy Joint Bone Spine 75 1 2008 34 40
138. C. Walter, B. Al-Nawas, K.A. Grötz, C. Thomas, J.W. Thüroff, and V. Zinser Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate Eur Urol 54 5 2008 1066 1072
139. J.A.H. Wass Bisphosphonate-induced osteonecrosis of the jaws: CT and MRI spectrum of findings in 32 patients Clin Radiol 63 1 2008 78 79
140. J.H. Wessels, T.B. Bidson, and A.I. Zavras Zoledronate and other risk factors associated with osteonecrosis of the jaw in cancer patients: a case-control study J Oral Maxillofac Surg 66 4 2008 625 631
141. A. Wutzl, E. Biedermann, F. Wanschitz, R. Seemann, C. Klug, and A. Baumann Osteonecrosis of the jaws Head Neck 30 9 2008 1224 1230
142. K. Alons, S.C.C. Kuijpers, E. De Jong, and R.J.P. Van Merkesteyn Treating low- and medium-potency bisphosphonate-related osteo-necrosis of the jaw with a protocol for the treatment of chronic suppurative osteomyelitis: report of 7 cases Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107 2 2009 e1 e7
143. M. Bonomi, R. Nortilli, A. Molina, T. Sava, A. Santo, and A. Caldara Renal toxicity and osteonecrosis of the jaw in cancer patients treated with bisphosphonates: a long-term retrospective analysis Med Oncol 27 2 2009 224 229
144. E.R. Carlson, and J.D. Baslie The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws J Oral Maxillofac Surg 67 Suppl. 5 2009 85 95
145. S. Cetiner, G.T. Sucak, S.A. Kahraman, S.Z. Aki, B. Kocakahyaoglu, and S.E. Gultekin Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid J Bone Miner Metab 27 4 2009 435 443
146. C. Christodoulou, A. Pervena, G. Klouvas, E. Galani, M.E. Falagas, and G. Tsakalos Combination of bisphosphonates and antiangiogenic factors induces osteonecrosis of the jaw more frequently than bisphosphonates alone Oncology 76 3 2009 209 211
147. G. Favia, G.P. Pilolli, and E. Maiorano Histologic and histomorphometric features of bisphosphonate-related osteonecrosis of the jaw: an analysis of 31 cases with confocal laser scanning microscopy Bone 45 3 2009 406 413
148. G. Favia, G.P. Pilolli, and E. Maiorano Osteonecrosis of the jaw correlated to bisphosphonate therapy in non-oncologic patients: clinico-pathological features of 24 patients J Rheumatol 36 12 2009 2780 2787
149. T. Fehm, V. Beck, M. Banys, H.P. Lipp, M. Hairass, and S. Reinert Bisphosphonate-induced osteonecrosis of the jaw (ONJ): incidence and risk factors in patients with breast cancer and gynaecological malignancies Gynecol Oncol 112 3 2009 605 609
150. A. Haidar, M. Jonler, T.B. Folkmar, and L. Lund Bisphosphonate (zoledronic acid)-induced osteonecrosis of the jaw Scand J Urol Nephrol 43 6 2009 442 444
151. J.W. Hong, W. Nam, I.H. Cha, S.W. Chung, H.S. Choi, and K.M. Kim Oral bisphosphonate-related osteonecrosis of the jaw: the first report in Asia Osteoporos Int 21 5 2010 847 853
152. J. Katz, T. George, P. Sandow, and M. Machado Bisphosphonate-induced osteonecrosis of the jaw: long-term outcomes J Support Oncol 7 1 2009 9 10
153. M. Kos, J.F. Kuebler, K. Luczak, and W. Engelke Bisphosphonate-related osteonecrosis of the jaws: a review of 34 cases and evaluation of risk J
154. N.M.H. McLeod, B.J. Davies, and P.A. Brennan Management of patients at risk of bisphosphonate osteonecrosis in maxillofacial surgery in the UK Surgeon 7 1 2009 18 23
155. F. Orlandini, D. Bossard, G. Blanc, A.G. Bodard, and R. Gourmet Osteonecrosis of the jaw and bisphosphonates: imaging features J Radiol 90 2 2009 199 205
156. F.S. O'Ryan, S. Khoury, W. Liao, M.M. Han, R.L. Hui, and D. Baer Intravenous bisphosphonate-related osteonecrosis of the jaw: bone scintigraphy as an early indicator J Oral Maxillofac Surg 67 7 2009 1363 1372
157. S.N. Rogers, J. Hung, A.J. Barber, and D. Lowe A survey of consultant members of the British Association of Oral and Maxillofacial Surgeons regarding bisphosphonate-induced osteonecrosis of the jaws Br J Oral Maxillofac Surg 47 8 2009 598 601
158. S. Saussed, R. Javadian, C. Hupin, M. Magremanne, G. Chantrain, and I. Loeb Bisphosphonate-related osteonecrosis of the jaw and its associated risk factors: a Belgian case series Laryngoscope 119 2 2009 323 329
159. P.P. Sedghizadeh, K. Stanley, M. Caligiuri, S. Hafkes, B. Lowry, and C.F. Shuler Oral bisphosphonates use and the prevalence of osteonecrosis of the jaw: an institutional inquiry J Am Dent Assoc 140 1 2009 61 66
160. P.P. Sedghizadeh, S.K.S. Kumar, A. Gorur, C. Schaudinn, C.F. Shuler, and J.W. Costerton Microbial biofilms in osteomyelitis of the jaw and osteonecrosis of the jaw secondary to bisphosphonate therapy J Am Dent Assoc 140 10 2009 1259 1265
161. D.C. Stanton, and E. Blasanian Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 cases J Oral Maxillofac Surg 67 5 2009 943 950
162. M.R. Stumpe, R.K. Chandra, F. Yunus, and S. Samant Incidence and risk factors of bisphosphonate-associated osteonecrosis of the jaws Head Neck 31 2 2009 202 206
163. Y. Takaishi, T. Ikeo, M. Nakajima, T. Miki, and T. Fujita A pilot case-control study on the alveolar bone density measurement in risk assessment for bisphosphonate-related osteonecrosis of the jaw Osteoporos Int 21 5 2010 815 825
164. V. Thumbigere-Math, M.C. Sabino, R. Gopalakrishnan, S. Huckabay, A.Z. Dudek, and S. Basu Bisphosphonate-related osteonecrosis of the jaw: clinical features, risk factors, management, and treatment outcomes of 26 patients J Oral Maxillofac Surg 67 9 2009 1904 1913
165. K. Vahtsevanos, A. Kyrgidis, E. Verrou, E. Katadritou, S. Triaridis, and C.G. Andreadis Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw J Clin Oncol 27 32 2009 5356 5362
166. C. Walter, B. Al-Nawas, A. Du Bois, L. Buch, P. Harter, and K.A. Grötz Incidence of bisphosphonate-associated osteonecrosis of the jaws in breast cancer patients Cancer 115 8 2009 1631 1637
167. F. Wilde, K. Seinhoff, B. Frerich, T. Schulz, K. Winter, and A. Hemprich Positron-emission tomography imaging in the diagnosis of bisphosphonate-related osteonecrosis of the jaw Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107 3 2009 412 419
168. C.A. Migliorati Bisphosphonates and oral cavity avascular bone necrosis J Clin Oncol 21 22 2003 4253 4258
169. J.P. Bilezikian Osteonecrosis of the jaw - do bisphosphonates pose a risk? N Engl J Med 355 22 2006 2278 2281
170. M.Q. Lacy, A. Dispenzieri, M.A. Gertz, P.R. Greipp, K.L. Gollbach, and S.R. Hayman Mayo clinic consensus statement for the use of bisphosphonates in multiple myeloma Mayo Clin Proc 81 8 2006 1047 1053
171. M. Marunick, and S. Gordon Prosthodontic treatment during active osteonecrosis related to radiation and bisphosphonate therapy: a clinical report J Prosthet Dent 96 1 2006 7 12
172. B. Mehrotra, and S. Ruggiero Bisphosphonate complications including osteonecrosis of the jaw Hematol Am Soc Hematol Educ Program 515 2006 356 360
173. E. Merigo, M. Manfredi, M. Meleti, R. Guidotti, A. Ripasarti, and E. Zanzucchi Bone necrosis of the jaws associated with bisphosphonate treatment: a report of twenty-nine cases Acta Biomed 77 2 2006 109 117
174. E. Shane, S. Goldring, S. Christakos, M. Drezner, J. Eisman, and S. Silverman Osteonecrosis of the jaw: more research needed J Bone Miner Res 21 19 2006 1503 1505
175. M.K. Jeffcoat Osteonecrosis in the jaws of patients who are using oral bisphosphonates to treat osteoporosis Int J Oral Maxillofacial Implants 22 1 2007 148 149
176. R.E. Marx Osteonecrosis in the jaws of patients who are using oral bisphosphonates to treat osteoporosis Int J Oral Maxillofac Implants 22 1 2007 149 151
177. B.J. Edwards, M. Gounder, J.M. McKoy, I. Boyd, M. Farrugia, and C. Migliorati Pharmacovigilance and reporting oversight in US FDA fast-track process: bisphosphonates and osteonecrosis of the jaw Lancet Oncol 9 12 2008 1166 1172
178. S.A. Guttenberg Bisphosphonates and bone.what have we learned? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 6 2008 769 772
179. S.J. Wimalawansa Insight into bisphosphonate-associated osteo-myelitis of the jaw: pathophysiology, mechanisms and clinical management Expert Opin Drug Saf 7 4 2008 491 512
180. K. Arce, L.A. Assael, J.L. Weissmnan, and M.R. Markiewicz Imaging finding in bisphosphonate-related osteonecrosis of jaws J Oral Maxillofac Surg 67 Suppl. 5 2009 75 84
181. L.A. Assael Oral bisphosphonates as a cause of bisphosphonate-related osteonecrosis of the jaws: clinical findings, assessment of risks, and preventive strategies J Oral Maxillofac Surg 67 Suppl. 5 2009 35 43
182. C. Barragan-Adjemian, L. Lausten, D.B. Ang, M. Johnson, J. Katz, and L.F. Bonewald Bisphosphonate-related osteonecrosis of the jaw: model and diagnosis with cone beam computerized tomography Cells Tissues Organs 189 1-4 2009 284 288
183. M. Dickinson, H.M. Prince, S. Kirsa, A. Zannettino, S.D.J. Gibbs, and L. Mileshin Osteonecrosis of the jaw complicating bisphosphonate treatment for bone disease in multiple myeloma: an overview with recommendations for preventing and treatment Intern Med J 39 5 2009 304 316
184. T.B. Dodson Intravenous bisphosphonate therapy and bisphosphonate-related osteonecrosis of the jaws J Oral Maxillofac Surg 67 Suppl. 5 2009 44 52
185. J.J. Freiberger Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws J Oral Maxillofac Surg 67 Suppl. 5 2009 96 106
186. A.A. Khan, G.K.B. Sandor, E. Dore, A.D. Morisson, M. Alsahli, and F. Amin Bisphosphonate associated osteonecrosis of the jaw J Rheumatol 36 3 2009 478 490
187. C. Ortega, R. Faggiuolo, R. Vormola, F. Montemurro, D. Nanni, and F. Goia Jaw complications in breast and prostate cancer patients treated with zoledronic acid Acta Oncol 45 2 2006 216 217
188. P. Tosi, E. Zamagni, D. Cangini, P. Tacchetti, F. Di Raimondo, and L. Catalano Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasone Blood 108 12 2006 3951 3952
189. P.A. Fugazzotto, W.S. Lightfoot, R. Jaffin, and A. Kumar Implant placement with or without simultaneous tooth extraction in patients taking oral bisphosphonates: postoperative healing, early follow-up, and the incidence of complications in two private practices J Periodontol 78 9 2007 1664 1669
190. P.F. Nocini, G. Saia, G. Bettini, M. Ragazzo, S. Blandamura, and L. Chiarini Vascularized fibula flap reconstruction of the mandible in bisphosphonate-related osteonecrosis Eur J Surg Oncol 35 4 2009 373 379
191. C.A. Migliorati, D.E. Schubert, D.E. Peterson, and L.M. Seneda Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone. An emerging oral complication of supportive cancer therapy Cancer 104 1 2005 83 93
192. C.M. Novince, B.W. Brent, and L.K. McCauley Osteonecrosis of the jaw: an update and review of recommendations Cells Tissues Organs 189 1-4 2009 275 283
193. C. Hewitt, and C.S. Farah Bisphosphonate-related osteonecrosis of the jaws: a comprehensive review J Oral Pathol Med 36 6 2007 319 328
194. R.E. Marx, Y. Sawatari, M. Forin, and V. Broumand Bisphosphonate-induced exposed bone (osteonecrosis/ osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment J Oral Maxillofac Surg 63 11 2005 1567 1575
195. S.B. Perez, M.V. Barrero, M.S. Hernandez, M. Knezevic, J.M. Castellano Navarro, and J.R. Millares Bisphosphonate-associated osteo-necrosis of the jaw. A proposal for conservative treatment Med Oral Patol Oral Cir Bucal 13 12 2008 E770 E773