An anionic synthetic sugar containing 6-SO3-NAcGlc mimics the sulfated cruzipain epitope that plays a central role in immune recognition

FEBS Journal

Volumn 279, Issue 19, 2012, Pages 3665-3679

  Couto, Alicia S ^a   Soprano, Luciana L ^b   Landoni, Malena ^a   Pourcelot, Marilyne ^c   Acosta, Diana M ^b   Bultel, Laurent ^c   Parente, Juliana ^a   Ferrero, Maximiliano R ^b   Barbier, Maximilien ^c   Dussouy, Christophe ^c   Esteva, Mõnica I ^b   Kovensky, José ^c   Duschak, Vilma G ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Administracion Nacional de Laboratorios E Institutos de Salud Dr Carlos G Malbran   (Argentina)

^c UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

cruzipain; epitope; glycoprotein; sulfated GlcNAc; Trypanosoma cruzi

Indexed keywords

ACETIC ACID DERIVATIVE; APROTININ; BOVINE SERUM ALBUMIN; CRUZIPAIN; DISACCHARIDE; IMMUNOGLOBULIN G; INORGANIC SALT; MONOSACCHARIDE; N ACETYL DEXTRO GLUCOSAMINE 6 SULFATE SODIUM SALT; OLIGOSACCHARIDE; SULFATE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CARBOXYLATION; CHAGAS DISEASE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME MODIFICATION; ENZYME STRUCTURE; ESTERIFICATION; FEMALE; HUMAN; IMMUNIZATION; IMMUNOASSAY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PRIORITY JOURNAL; RABBIT; STRUCTURE ACTIVITY RELATION; SULFATION; SURFACE CHARGE; TRYPANOSOMA CRUZI;

ACETYLGLUCOSAMINE; ADOLESCENT; ADULT; ANIMALS; ANIONS; CASE-CONTROL STUDIES; CHAGAS DISEASE; CYSTEINE ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; IMMUNOGLOBULIN G; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; OLIGOSACCHARIDES; RABBITS; SEROLOGIC TESTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SULFATES; TRYPANOSOMA CRUZI; YOUNG ADULT;

ORYCTOLAGUS CUNICULUS; TRYPANOSOMA CRUZI;

EID: 84866371595     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08728.x     Document Type: Article

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