Defective intestinal amino acid absorption in Ace2 null mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 303, Issue 6, 2012, Pages

  Singer, Dustin ^a   Camargo, Simone M R ^a   Ramadan, Tamara ^a   Schäfer, Matthias ^b   Mariotta, Luca ^a   Herzog, Brigitte ^a   Huggel, Katja ^a   Wolfer, David ^a   Werner, Sabine ^b   Penninger, Josef M ^c   Verrey, François ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

Angiotensin converting enzyme 2; Hartnup disorder; L tryptophan; Niacin

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; MEMBRANE PROTEIN; NICOTINIC ACID; PROLINE; PROTEIN ACE2; PROTEIN SLC6A19; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; AMINOACIDURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CONTROLLED STUDY; GLUCOSE TRANSPORT; HARTNUP DISEASE; HOMEOSTASIS; INTESTINE ABSORPTION; MALE; MOUSE; NEWBORN; NONHUMAN; PELLAGRA; PHOTOSENSITIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RESTRICTION; RASH; SMALL INTESTINE; WEIGHT GAIN;

ABSORPTION; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; AMINO ACIDS; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; DIET; DIETARY PROTEINS; GENE EXPRESSION REGULATION; GENOTYPE; HOMEOSTASIS; INTESTINES; MALE; MICE; MICE, KNOCKOUT; NIACIN; PEPTIDYL-DIPEPTIDASE A; TIME FACTORS;

EID: 84866355120     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00140.2012     Document Type: Article

References (37)

1. +/amino acid transporter 1 (PAT1) is the imino acid carrier: an intestinal nutrient/drug transporter in human and rat. Gastroenterology 127: 1410-1422, 2004.
2. Babu S, Shareef M, Shetty A, Shetty K. HPLC method for urea nitrogen measurement in whole serum. Indian J Clin Biochem 7: 7-26, 2002.
3. Baron DN, Dent CE, Harris H, Hart EW, Jepson JB. Hereditary pellagra-like skin rash with temporary cerebellar ataxia, constant renal amino-aciduria, and other bizarre biochemical features. Lancet 271: 421-428, 1956.
4. Bender DA. Effects of a dietary excess of leucine on the metabolism of tryptophan in the rat: a mechanism for the pellagragenic action of leucine. Br J Nutr 50: 25-32, 1983.
5. 0AT1 (slc6a19). Biochem J 389: 745-751, 2005.
6. Boll M, Daniel H, Gasnier B. The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis. Pflügers Arch 447: 776-779, 2004.
7. + neutral amino acid cotransporter (Slc6a19)-deficient mouse. J Biol Chem 286: 26638-26651.
8. 0, a neutral amino acid transporter related to Hartnup disorder. J Biol Chem 279: 24467-24476, 2004.
9. Brosnan ME, Brosnan JT. Hepatic glutamate metabolism: a tale of 2 hepatocytes. Am J Clin Nutr 90: 857S-861S, 2009.
10. 0AT1 sodium-dependent neutral amino acid transporter. Pflügers Arch 451: 338-348, 2005.
11. Camargo SM, Singer D, Makrides V, Huggel K, Pos KM, Wagner CA, Kuba K, Danilczyk U, Skovby F, Kleta R, Penninger JM, Verrey F. Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with Hartnup mutations. Gastroenterology 136: 872-882, 2009.
12. Christie GR, Ford D, Howard A, Clark MA, Hirst BH. Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1. Gastroenterology 120: 439-448, 2001.
13. Cohen SA, De Antonis KM. Applications of amino acid derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. Analysis of feed grains, intravenous solutions and glycoproteins. J Chromatogr A 661: 25-34, 1994.
14. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417: 822-828, 2002.
15. Danilczyk U, Sarao R, Remy C, Benabbas C, Stange G, Richter A, Arya S, Pospisilik JA, Singer D, Camargo SM, Makrides V, Ramadan T, Verrey F, Wagner CA, Penninger JM. Essential role for collectrin in renal amino acid transport. Nature 444: 1088-1091, 2006.
16. Dejong CH, van de Poll MC, Soeters PB, Jalan R, Olde Damink SW. Aromatic amino acid metabolism during liver failure. J Nutr 137: 1579S-1585S, 2007.
17. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H. The emerging role of ACE2 in physiology and disease. J Pathol 212: 1-11, 2007.
18. 0AT1, cause Hartnup disorder. Nat Genet 36: 999-1002, 2004.
19. +-dependent proline transporter. Biochem J 386: 417-422, 2005.
20. Kowalczuk S, Broer A, Tietze N, Vanslambrouck JM, Rasko JE, Broer S. A protein complex in the brush-border membrane explains a Hartnup disorder allele. FASEB J 22: 2880-2887, 2008.
21. Levy LL (Editor). The Metabolic and Molecular Bases of Inherited Diseases. New York: McGraw-Hill, 2001, p. 4957-4969.
22. Malakauskas SM, Quan H, Fields TA, McCall SJ, Yu MJ, Kourany WM, Frey CW, Le TH. Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. Am J Physiol Renal Physiol 292: F533-F544, 2007.
23. Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, Bennett DA, Wilson RS, Aggarwal N. Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline. J Neurol Neurosurg Psychiatry 75: 1093-1099, 2004.
24. Niu MJ, Yang JK, Lin SS, Ji XJ, Guo LM. Loss of angiotensinconverting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine 34: 56-61, 2008.
25. Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol 168: 1808-1820, 2006.
26. Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res 75: 29-39, 2007.
27. Reeves PG, Rossow KL, Lindlauf J. Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcification and bone mineralization in rats and mice. J Nutr 123: 1923-1931, 1993.
28. 0AT-cluster and their tissue distribution in Mus musculus. Am J Physiol Renal Physiol 290: F376-F383, 2006.
29. Scriver CR, Mahon B, Levy HL, Clow CL, Reade TM, Kronick J, Lemieux B, Laberge C. The Hartnup phenotype: Mendelian transport disorder, multifactorial disease. Am J Hum Genet 40: 401-412, 1987.
30. Seaton B, Ali A. Simplified manual high performance clinical chemistry methods for developing countries. Med Lab Sci 41: 327-336, 1984.
31. Seow HF, Broer S, Broer A, Bailey CG, Potter SJ, Cavanaugh JA, Rasko JE. Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet 36: 1003-1007, 2004.
32. Srikantia SG, Venkatachalam PS, Reddy V. Clinical and biochemical features of a case of Hartnup disease. Br Med J 1: 282-285, 1964.
33. Sugiura S, Kitagawa K, Tanaka S, Todo K, Omura-Matsuoka E, Sasaki T, Mabuchi T, Matsushita K, Yagita Y, Hori M. Adenovirusmediated gene transfer of heparin-binding epidermal growth factor-like growth factor enhances neurogenesis and angiogenesis after focal cerebral ischemia in rats. Stroke 36: 859-864, 2005.
34. van Donkelaar EL, Blokland A, Lieben CK, Kenis G, Ferrington L, Kelly PA, Steinbusch HW, Prickaerts J. Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes. Neurochem Int 56: 21-34, 2009.
35. Wan P, Moat S, Anstey A. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol 164: 1188-1200.
36. Wong TP, Debnam ES, Leung PS. Involvement of an enterocyte reninangiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush-border membrane. J Physiol 584: 613-623, 2007.
37. Wybenga DR, Di Giorgio J, Pileggi VJ. Manual and automated methods for urea nitrogen measurement in whole serum. Clin Chem 17: 891-895, 1971.