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Volumn 127, Issue 5, 2004, Pages 1410-1422

H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; COTRANSPORTER; HYDROGEN; IMINO ACID; PROTON COUPLED AMINO ACID TRANSPORTER 1; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

EID: 7644230471     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.08.017     Document Type: Article
Times cited : (120)

References (59)
  • 4
    • 7644238424 scopus 로고    scopus 로고
    • The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membranetransport proteins--introduction
    • M.A. Hediger, M.F. Romero, J.B. Peng, A. Rolfs, H. Takanaga, E.A. Bruford The ABCs of solute carriers physiological, pathological and therapeutic implications of human membranetransport proteins--introduction Pflugers Arch 447 2004 1 942
    • (2004) Pflugers Arch , vol.447 , pp. 1-942
    • Hediger, M.A.1    Romero, M.F.2    Peng, J.B.3    Rolfs, A.4    Takanaga, H.5    Bruford, E.A.6
  • 6
    • 0021952773 scopus 로고
    • Substrate specificity of the intestinal brush-border proline/sodium (IMINO) transporter
    • B.R. Stevens, E.M. Wright Substrate specificity of the intestinal brush-border proline/sodium (IMINO) transporter J Membr Biol 87 1985 27 34
    • (1985) J Membr Biol , vol.87 , pp. 27-34
    • Stevens, B.R.1    Wright, E.M.2
  • 7
    • 0036641749 scopus 로고    scopus 로고
    • D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia
    • A.E. Evins, E. Amico, T.A. Posever, R. Toker, D.C. Goff d-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia Schizophr Res 56 2002 19 23
    • (2002) Schizophr Res , vol.56 , pp. 19-23
    • Evins, A.E.1    Amico, E.2    Posever, T.A.3    Toker, R.4    Goff, D.C.5
  • 8
    • 0032403626 scopus 로고    scopus 로고
    • D-Serine added to antipyschotics for the treatment of schizophrenia
    • G. Tsai, P. Yang, L.-C. Chung, N. Lange, J.T. Coyle d-Serine added to antipyschotics for the treatment of schizophrenia Biol Psychiatry 44 1998 1081 1089
    • (1998) Biol Psychiatry , vol.44 , pp. 1081-1089
    • Tsai, G.1    Yang, P.2    Chung, L.-C.3    Lange, N.4    Coyle, J.T.5
  • 9
    • 0019406681 scopus 로고
    • The use of betaine for the treatment of homocystinuria
    • L.A. Smolin, N.J. Benevenga, S. Berlow The use of betaine for the treatment of homocystinuria J Pediatr 99 1981 467 472
    • (1981) J Pediatr , vol.99 , pp. 467-472
    • Smolin, L.A.1    Benevenga, N.J.2    Berlow, S.3
  • 10
    • 7644227352 scopus 로고
    • The transfer system for neutral amino acids in the rat small intestine
    • H. Newey, D.H. Smyth The transfer system for neutral amino acids in the rat small intestine J Physiol 170 1964 328 343
    • (1964) J Physiol , vol.170 , pp. 328-343
    • Newey, H.1    Smyth, D.H.2
  • 11
    • 0014013019 scopus 로고
    • Amino acid transport by the small intestine of the rat
    • B.G. Munck Amino acid transport by the small intestine of the rat Biochim Biophys Acta 120 1966 97 103
    • (1966) Biochim Biophys Acta , vol.120 , pp. 97-103
    • Munck, B.G.1
  • 12
    • 0002878914 scopus 로고
    • Intestinal absorption of amino acids
    • L.R. Johnson Raven Press New York
    • B.G. Munck Intestinal absorption of amino acids L.R. Johnson Physiology of the gastrointestinal tract 1981 Raven Press New York 1097 1122
    • (1981) Physiology of the Gastrointestinal Tract , pp. 1097-1122
    • Munck, B.G.1
  • 13
    • 0021929251 scopus 로고
    • Transport of imino acids and non-α-amino acid across the brush-border membrane of the rabbit ileum
    • B.G. Munck Transport of imino acids and non-α-amino acid across the brush-border membrane of the rabbit ileum J Membr Biol 83 1985 15 24
    • (1985) J Membr Biol , vol.83 , pp. 15-24
    • Munck, B.G.1
  • 14
    • 0026573348 scopus 로고
    • Distinction between chloride-dependent transport systems for taurine and β-alanine in rabbit ileum
    • L.K. Munck, B.G. Munck Distinction between chloride-dependent transport systems for taurine and β-alanine in rabbit ileum Am J Physiol 262 1992 G609 G615
    • (1992) Am J Physiol , vol.262
    • Munck, L.K.1    Munck, B.G.2
  • 15
    • 0028343746 scopus 로고
    • Chloride-dependent intestinal transport of imino and β-amino acids in the guinea pig and rat
    • L.K. Munck, B.G. Munck Chloride-dependent intestinal transport of imino and β-amino acids in the guinea pig and rat Am J Physiol 266 1994 R997 R1007
    • (1994) Am J Physiol , vol.266
    • Munck, L.K.1    Munck, B.G.2
  • 19
    • 0029057614 scopus 로고
    • The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers
    • D.T. Thwaites, G.T.A. McEwan, N.L. Simmons The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers J Membr Biol 145 1995 245 256
    • (1995) J Membr Biol , vol.145 , pp. 245-256
    • Thwaites, D.T.1    McEwan, G.T.A.2    Simmons, N.L.3
  • 20
    • 0033964573 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers
    • D.T. Thwaites, L. Basterfield, P.M.J. McCleave, S.M. Carter, N.L. Simmons Gamma-aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers Br J Pharmacol 129 2000 457 464
    • (2000) Br J Pharmacol , vol.129 , pp. 457-464
    • Thwaites, D.T.1    Basterfield, L.2    McCleave, P.M.J.3    Carter, S.M.4    Simmons, N.L.5
  • 23
    • 0026595620 scopus 로고
    • Physiological actions of taurine
    • R.J. Huxtable Physiological actions of taurine Physiol Rev 72 1992 101 163
    • (1992) Physiol Rev , vol.72 , pp. 101-163
    • Huxtable, R.J.1
  • 24
    • 0014454148 scopus 로고
    • Stereochemical specificity of neutral amino acid transfer systems in rat small intestine
    • V.G. Daniels, H. Newey, D.H. Smyth Stereochemical specificity of neutral amino acid transfer systems in rat small intestine Biochim Biophys Acta 183 1969 637 639
    • (1969) Biochim Biophys Acta , vol.183 , pp. 637-639
    • Daniels, V.G.1    Newey, H.2    Smyth, D.H.3
  • 25
    • 0015041195 scopus 로고
    • Transfer of alanine isomers by rat small intestine
    • J. De la Noue, H. Newey, D.H. Smyth Transfer of alanine isomers by rat small intestine J Physiol 214 1971 105 114
    • (1971) J Physiol , vol.214 , pp. 105-114
    • De La Noue, J.1    Newey, H.2    Smyth, D.H.3
  • 26
    • 0014934360 scopus 로고
    • The stimulating effect of low pH on the amino acid transferring systems of the small intestine
    • E. Thompson, R.J. Levin, M.J. Jackson The stimulating effect of low pH on the amino acid transferring systems of the small intestine Biochim Biophys Acta 196 1970 120 122
    • (1970) Biochim Biophys Acta , vol.196 , pp. 120-122
    • Thompson, E.1    Levin, R.J.2    Jackson, M.J.3
  • 27
    • 0021288939 scopus 로고
    • Intestinal transport of amino acids and sugars: Advances using membrane vesicles
    • B.R. Stevens, J.D. Kaunitz, E.M. Wright Intestinal transport of amino acids and sugars advances using membrane vesicles Annu Rev Physiol 46 1984 417 433
    • (1984) Annu Rev Physiol , vol.46 , pp. 417-433
    • Stevens, B.R.1    Kaunitz, J.D.2    Wright, E.M.3
  • 28
    • 0028962660 scopus 로고
    • Amino acid transport by small intestinal, hepatic, and pancreatic epithelia
    • M.E. Mailliard, B.R. Stevens, G.E. Mann Amino acid transport by small intestinal, hepatic, and pancreatic epithelia Gastroenterology 108 1995 888 910
    • (1995) Gastroenterology , vol.108 , pp. 888-910
    • Mailliard, M.E.1    Stevens, B.R.2    Mann, G.E.3
  • 29
    • 0031751209 scopus 로고    scopus 로고
    • Molecular biology of mammalian plasma membrane amino acid transporters
    • M. Palacin, R. Estevez, J. Bertran, A. Zorzano Molecular biology of mammalian plasma membrane amino acid transporters Physiol Rev 78 1998 969 1054
    • (1998) Physiol Rev , vol.78 , pp. 969-1054
    • Palacin, M.1    Estevez, R.2    Bertran, J.3    Zorzano, A.4
  • 30
    • 0037440176 scopus 로고    scopus 로고
    • Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2
    • Z. Chen, Y.J. Fei, C.M.H. Anderson, K.A. Wake, S. Miyauchi, W. Huang, D.T. Thwaites, V. Ganapathy Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2 J Physiol 546 2003 349 361
    • (2003) J Physiol , vol.546 , pp. 349-361
    • Chen, Z.1    Fei, Y.J.2    Anderson, C.M.H.3    Wake, K.A.4    Miyauchi, S.5    Huang, W.6    Thwaites, D.T.7    Ganapathy, V.8
  • 31
    • 0037603307 scopus 로고    scopus 로고
    • A cluster of proton/amino acid transporter genes in the human and mouse genomes
    • M. Boll, M. Foltz, I. Rubio-Aliaga, H. Daniel A cluster of proton/amino acid transporter genes in the human and mouse genomes Genomics 82 2003 47 56
    • (2003) Genomics , vol.82 , pp. 47-56
    • Boll, M.1    Foltz, M.2    Rubio-Aliaga, I.3    Daniel, H.4
  • 33
    • 0025782599 scopus 로고
    • Multiple pathways for amino acid transport in brush border membrane vesicles isolated from the human fetal small intestine
    • C. Malo Multiple pathways for amino acid transport in brush border membrane vesicles isolated from the human fetal small intestine Gastroenterology 100 1991 1644 1652
    • (1991) Gastroenterology , vol.100 , pp. 1644-1652
    • Malo, C.1
  • 34
    • 0022106251 scopus 로고
    • Is intestinal peptide transport energized by a proton gradient?
    • V. Ganapathy, F.H. Leibach Is intestinal peptide transport energized by a proton gradient? Am J Physiol 249 1985 G289 G294
    • (1985) Am J Physiol , vol.249
    • Ganapathy, V.1    Leibach, F.H.2
  • 38
    • 0023747201 scopus 로고
    • The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo
    • G.T.A. McEwan, H. Daniel, C. Fett, M.N. Burgess, M.L. Lucas The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo Proc R Soc Lond B 234 1988 219 237
    • (1988) Proc R Soc Lond B , vol.234 , pp. 219-237
    • McEwan, G.T.A.1    Daniel, H.2    Fett, C.3    Burgess, M.N.4    Lucas, M.L.5
  • 39
    • 0024447698 scopus 로고
    • Demonstration and modification of intervillous pH profiles in rat small intestine in vitro
    • H. Daniel, C. Fett, A. Kratz Demonstration and modification of intervillous pH profiles in rat small intestine in vitro Am J Physiol 257 1989 G489 G495
    • (1989) Am J Physiol , vol.257
    • Daniel, H.1    Fett, C.2    Kratz, A.3
  • 40
    • 0037151112 scopus 로고    scopus 로고
    • Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
    • M. Boll, M. Foltz, I. Rubio-Aliaga, G. Kottra, H. Daniel Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters J Biol Chem 277 2002 22966 22973
    • (2002) J Biol Chem , vol.277 , pp. 22966-22973
    • Boll, M.1    Foltz, M.2    Rubio-Aliaga, I.3    Kottra, G.4    Daniel, H.5
  • 41
    • 0032919687 scopus 로고    scopus 로고
    • Effects of pH changes on systems ASC and B in rabbit ileum
    • B.G. Munck, L.K. Munck Effects of pH changes on systems ASC and B in rabbit ileum Am J Physiol 276 1999 G173 G184
    • (1999) Am J Physiol , vol.276
    • Munck, B.G.1    Munck, L.K.2
  • 42
    • 7644222618 scopus 로고    scopus 로고
    • Neutral amino acid transport via system L at the basolateral membrane of human intestinal Caco-2 cell monolayers
    • L.R.R. McCloy, P.M. Taylor, D.T. Thwaites Neutral amino acid transport via system L at the basolateral membrane of human intestinal Caco-2 cell monolayers J Physiol 535P 2001 48P 49P
    • (2001) J Physiol , vol.535
    • McCloy, L.R.R.1    Taylor, P.M.2    Thwaites, D.T.3
  • 43
    • 0028124811 scopus 로고
    • The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport
    • Y. Kanai, M. Stelzner, S. Nussberger, S. Khawaja, S.C. Hebert, C.P. Smith, M.A. Hediger The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport J Biol Chem 269 1994 20599 20606
    • (1994) J Biol Chem , vol.269 , pp. 20599-20606
    • Kanai, Y.1    Stelzner, M.2    Nussberger, S.3    Khawaja, S.4    Hebert, S.C.5    Smith, C.P.6    Hediger, M.A.7
  • 45
    • 0028851256 scopus 로고
    • Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion
    • W. Scholtz, U. Albus, L. Counillon, H. Gogelein, H.J. Lang, W. Linz, A. Weichert, B.A. Scholkens Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion Cardiovasc Res 29 1995 260 268
    • (1995) Cardiovasc Res , vol.29 , pp. 260-268
    • Scholtz, W.1    Albus, U.2    Counillon, L.3    Gogelein, H.4    Lang, H.J.5    Linz, W.6    Weichert, A.7    Scholkens, B.A.8
  • 46
    • 0027282066 scopus 로고
    • Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger
    • J. Orlowski Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger J Biol Chem 268 1993 16369 16377
    • (1993) J Biol Chem , vol.268 , pp. 16369-16377
    • Orlowski, J.1
  • 47
    • 0014500872 scopus 로고
    • Effect of carbon chain length and amino group position on neutral amino acid transport systems in rat small intestine
    • V.G. Daniels, A.G. Dawson, H. Newey, D.H. Smyth Effect of carbon chain length and amino group position on neutral amino acid transport systems in rat small intestine Biochim Biophys Acta 173 1969 575 577
    • (1969) Biochim Biophys Acta , vol.173 , pp. 575-577
    • Daniels, V.G.1    Dawson, A.G.2    Newey, H.3    Smyth, D.H.4
  • 51
    • 0033663126 scopus 로고    scopus 로고
    • An l-proline-dependent proton flux is located at the apical membrane level of the eel enterocytes
    • L. Ingrosso, S. Marsigliante, V. Zonno, C. Storelli, S. Vilella An l-proline-dependent proton flux is located at the apical membrane level of the eel enterocytes Am J Physiol 279 2000 R1619 R1624
    • (2000) Am J Physiol , vol.279
    • Ingrosso, L.1    Marsigliante, S.2    Zonno, V.3    Storelli, C.4    Vilella, S.5
  • 53
    • 0023645814 scopus 로고
    • Proton gradient dependent transport of glycine in rabbit renal brush border membrane vesicles
    • V.M. Rajendran, J.A. Barry, J.G. Kleinman, K. Ramaswamy Proton gradient dependent transport of glycine in rabbit renal brush border membrane vesicles J Biol Chem 262 1987 14974 14977
    • (1987) J Biol Chem , vol.262 , pp. 14974-14977
    • Rajendran, V.M.1    Barry, J.A.2    Kleinman, J.G.3    Ramaswamy, K.4
  • 55
    • 0034853172 scopus 로고    scopus 로고
    • The effects of red bull energy drink on human performance and mood
    • C. Alford, H. Cox, R. Wescott The effects of red bull energy drink on human performance and mood Amino Acids 21 2001 139 150
    • (2001) Amino Acids , vol.21 , pp. 139-150
    • Alford, C.1    Cox, H.2    Wescott, R.3
  • 56
    • 0033380753 scopus 로고    scopus 로고
    • Cytotoxicity of l-cycloserine against human neuroblastoma and medulloblastoma cells is associated with the suppression of ganglioside expression
    • J. Cinatl, J. Cinatl, R. Kotchetkov, P. Pouckova, J.U. Vogel, H. Rabineau, M. Michaelis, B. Kornhuber Cytotoxicity of l-cycloserine against human neuroblastoma and medulloblastoma cells is associated with the suppression of ganglioside expression Anticancer Res 19 1999 5349 5354
    • (1999) Anticancer Res , vol.19 , pp. 5349-5354
    • Cinatl, J.1    Cinatl, J.2    Kotchetkov, R.3    Pouckova, P.4    Vogel, J.U.5    Rabineau, H.6    Michaelis, M.7    Kornhuber, B.8
  • 59
    • 0037380607 scopus 로고    scopus 로고
    • Intestinal ion transport and the pathophysiology of diarrhea
    • M. Field Intestinal ion transport and the pathophysiology of diarrhea J Clin Invest 111 2003 931 943
    • (2003) J Clin Invest , vol.111 , pp. 931-943
    • Field, M.1


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