Elevated resting heart rate is associated with white blood cell count in middle-aged and elderly individuals without apparent cardiovascular disease

Angiology

Volumn 63, Issue 7, 2012, Pages 541-546

  Inoue, Taku ^a   Iseki, Kunitoshi ^a   Iseki, Chiho ^a   Kinjo, Kozen ^b  

^a UNIVERSITY HOSPITAL OF THE RYUKYUS   (Japan)

^b Okinawa General Health Maintenance Association   (Japan)

Author keywords

atherosclerosis; heart rate; inflammation; surrogate marker; white blood cell count

Indexed keywords

GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; FEMALE; GLUCOSE BLOOD LEVEL; HEART RATE; HUMAN; JAPANESE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; SMOKING;

AGE FACTORS; AGED; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; COHORT STUDIES; FEMALE; HEART RATE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFLAMMATION; JAPAN; LEUKOCYTE COUNT; MALE; MIDDLE AGED; ODDS RATIO; RISK FACTORS; SEX FACTORS; TRIGLYCERIDES; URIC ACID;

EID: 84866344098     PISSN: 00033197     EISSN: 19401574     Source Type: Journal    
DOI: 10.1177/0003319711428071     Document Type: Article

References (30)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993 ; 362 (6423). 801-809
2. Morrow DA, Rifai N, Antman EM, et al. C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy. Thrombolysis in Myocardial Infarction. J Am Coll Cardiol. 1998 ; 31 (7). 1460-1465
3. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997 ; 336 (14). 973-979
4. Taniguchi H, Momiyama Y, Ohmori R, et al. Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease. Atherosclerosis. 2005 ; 178 (1). 173-177
5. Zhang R, Brennan ML, Fu X, et al. Association between myeloperoxidase levels and risk of coronary artery disease. JAMA. 2001 ; 286 (17). 2136-2142
6. Cavusoglu E, Chopra V, Gupta A, et al. Usefulness of the white blood cell count as a predictor of angiographic findings in an unselected population referred for coronary angiography. Am J Cardiol. 2006 ; 98 (9). 1189-1193
7. Kannel WB, Kannel C, Paffenbarger RS, Cupples LA. Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J. 1987 ; 113 (6). 1489-1494
8. Palatini P, Casiglia E, Julius S, Pessina AC. High heart rate: a risk factor for cardiovascular death in elderly men. Arch Intern Med. 1999 ; 159 (6). 585-592
9. Diaz A, Bourassa MG, Guertin MC, Tardif JC. Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J. 2005 ; 26 (10). 967-974
10. Bangalore S, Messerli FH, Ou FS, et al. CRUSADE Investigators The association of admission heart rate and in-hospital cardiovascular events in patients with non-ST-segment elevation acute coronary syndromes: results from 135 164 patients in the CRUSADE quality improvement initiative. Eur Heart J. 2010 ; 31 (5). 552-560
11. Iseki K, Nakai S, Yamagata K, Tsubakihara Y. Tachycardia as a predictor of poor survival in chronic haemodialysis patients. Nephrol Dial Transplant. 2011 ; 26 (3). 963-969
12. Custodis F, Baumhakel M, Schlimmer N, et al. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2008 ; 117 (18). 2377-2387
13. Perski A, Olsson G, Landou C, de Faire U, Theorell T, Hamsten A. Minimum heart rate and coronary atherosclerosis: independent relations to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age. Am Heart J. 1992 ; 123 (3). 609-616
14. Heidland UE, Strauer BE. Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption. Circulation. 2001 ; 104 (13). 1477-1482
15. Palatini P, Julius S. Heart rate and the cardiovascular risk. J Hypertens. 1997 ; 15 (1). 3-17
16. Inoue T, Oshiro S, Iseki K, et al. High heart rate relates to clustering of cardiovascular risk factors in a screened cohort. Jpn Circ J. 2001 ; 65 (11). 969-973
17. de Rooij SR, Nijpels G, Nilsson PM, et al. Relationship Between Insulin Sensitivity and Cardiovascular Disease (RISC) Investigators. Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile. Diabetes Care. 2009 ; 32 (7). 1295-1301
18. Kuller LH, Tracy RP, Shaten J, Meilahn EN. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial. Am J Epidemiol. 1996 ; 144 (6). 537-547
19. Das I. Raised C-reactive protein levels in serum from smokers. Clin Chim Acta. 1985 ; 153 (1). 9-13
20. Sajadieh A, Nielsen OW, Rasmussen V, Hein HO, Abedini S, Hansen JF. Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease. Eur Heart J. 2004 ; 25 (5). 363-370
21. Hasegawa T, Watase H. Association of heart rate with coronary risk factors and increased white blood cell counts in healthy Japanese people. J Atheroscler Thromb. 2003 ; 10 (4). 259-263
22. Jensen-Urstad M, Jensen-Urstad K, Ericson M, Johansson J. Heart rate variability is related to leucocyte count in men and to blood lipoproteins in women in a healthy population of 35-year-old subjects. J Intern Med. 1998 ; 243 (1). 33-40
23. Inoue T, Iseki K, Iseki C, Ohya Y, Kinjo K, Takishita S. Effect of heart rate on the risk of developing metabolic syndrome. Hypertens Res. 2009 ; 32 (9). 801-806
24. Festa A, D'Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000 ; 102 (1). 42-47
25. Braunwald E, ed Braunwald's Heart Disease. 8 th ed. Philadelphia, PA: Saunders. Philadelphia, PA: Saunders ;
26. Inoue T, Ohya Y. Elevated heart rate, a risk factor and risk marker of cardiovascular disease. Curr Hypertens Rev. 2011 ; 7 (1). 29-40
27. De Keulenaer GW, Chappell DC, Ishizaka N, Nerem RM, Alexander RW, Griendling KK. Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase. Circ Res. 1998 ; 82 (10). 1094-1101
28. Himburg HA, Dowd SE, Friedman MH. Frequency-dependent response of the vascular endothelium to pulsatile shear stress. Am J Physiol Heart Circ Physiol. 2007 ; 293 (1). H645 - H653
29. Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res. 1998 ; 82 (5). 532-539
30. Palatini P, Benetos A, Grassi G, et al. European Society of Hypertension Identification and management of the hypertensive patient with elevated heart rate: statement of a European Society of Hypertension consensus meeting. J Hypertens. 2006 ; 24 (4). 603-610