Responsiveness of prehaemolytic copper poisoning in sheep from a specific pathogen-free environment to a relatively high dose of tetrathiomolybdate

Veterinary Record

Volumn 171, Issue 10, 2012, Pages 246-

  Suttle, N F ^a  

^a Moredun Foundation   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; COPPER; ENZYME INHIBITOR; MOLYBDENUM; SUPEROXIDE DISMUTASE; TETRATHIOMOLYBDIC ACID;

ANIMAL; ARTICLE; BLOOD; DRUG EFFECT; ENZYMOLOGY; ERYTHROCYTE; GERMFREE ANIMAL; METABOLISM; RANDOMIZATION; SHEEP; SHEEP DISEASE; TREATMENT OUTCOME;

ANIMALS; ASPARTATE AMINOTRANSFERASES; COPPER; ENZYME INHIBITORS; ERYTHROCYTES; MOLYBDENUM; RANDOM ALLOCATION; SHEEP; SHEEP DISEASES; SPECIFIC PATHOGEN-FREE ORGANISMS; SUPEROXIDE DISMUTASE; TREATMENT OUTCOME;

OVIS ARIES;

EID: 84866300746     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.100722     Document Type: Article

References (15)

1. ALVAREZ, H. M., XUE, Y. & ROBINSON, C. D. (2010) Tetrathiomolyb date inhibits copper trafficking proteins through metal cluster formation. Science 327, 331-334
2. ASKARI, F. K., DICK, R., MAO, M. & BREWER, G. J. (2004) Tetrathiomolyb date therapy protects against concanavillin A and carbon tetrachloride hepatic damage in mice. Experimental Biology and Medicine 229, 857-863
3. GOONERATNE, S. R., HOWELL, J. M. & GAWTHORNE, J. M. (1981) Intravenous administration of thiomolybdate for the prevention and treatment of chronic copper poisoning in sheep. British Journal of Nutrition 46, 457-467
4. GOONERATNE, S. R., HOWELL, J. M. & GAWTHORNE, J. M. (1981) An investigation of the effects of intravenous administration of thiomolybdate on copper metabolism in chronic Cu-poisoned sheep. British Journal of Nutrition 46, 469-480
5. HAYWOOD, S., DINCER, Z., JASANI, B. & LOUGHRAN, M. J. (2004) Molybdenumassociated pituitary endocrinopathy in sheep treated with ammonium Tetrathiomolyb date. Journal of Comparative Pathology 130, 21-31
6. HOWELL, J. M. & KUMARATILAKE, J. S. (1990) Effect of intravenously administered Tetrathiomolyb date on plasma copper concentrations of copper-loaded sheep. Journal of Comparative Pathology 103, 321-334
7. HUMPHRIES, W. R., MILLS, C. F., GREIG, A., ROBERTS, L., INGLIS, D. & HALLIDAY, G. J. (1986) Use of ammonium Tetrathiomolyb date in the treatment of copper poisoning in sheep. Veterinary Record 119, 596-598
8. HUMPHRIES, W. R., MORRICE, P. C. & BREMNER, I. (1988) A convenient method for the treatment of chronic copper poisoning in sheep using ammonium Tetrathiomolyb date Veterinary Record 123, 51-53
9. JUAREZ, J. C., BETANCOURT, O., PIRIE-SHEPHERD, S. R., GUAN, X., PRICE, M. L., SHAW, D. E., MAZAR, A. P. & DONATE, F. (2006) Copper binding by Tetrathiomolyb date attenuates angiogenesis and tumor cell proliferation through inhibition of superoxide dismutase 1. Clinical Cancer Research 12, 4974-4982
10. OGRA, Y., KOMADA, Y. & SUZUKI, K. T. (1999) Comparative mechanism and toxicity of tetra- and dithiomolybdates in the removal of copper. Journal of Inorganic Biochemistry 75, 199-204
11. OGRA, Y. & SUZUKI, K. T. (1998) Targeting of Tetrathiomolyb date on the copper accumulating in the liver of LEC rats. Journal of Inorganic Biochemistry 70, 49-55
12. SUTTLE, N. F. (2008) Lack of effect of parenteral thiomolybdate on ovine caeruloplasmin activity: diagnostic implications. Veterinary Record 162, 593-594
13. SUTTLE, N. F. (2010) 'Copper', Chapter 11 in 'Mineral Nutrition of Livestock. 4th edn. CABI International. pp 255-305
14. SUTTLE, N. F. (2012a) Residual effects of Mycobacterium avium infection on the susceptibility of sheep to copper toxicity and the efficacy of conservative treatment with Tetrathiomolyb date Veterinary Record
15. SUTTLE, N. F. (2012b) Control of hepatic copper retention in Texel ram lambs by dietary supplementation with copper antagonists followed by a copper depletion regimen. Animal Feed Science and Technology 173, 194-200