Intracoronary levosimendan during ischemia prevents myocardial apoptosis

Frontiers in Physiology

Volumn 3 FEB, Issue , 2012, Pages

  Malmberg, Markus ^a,b   Vähäsilta, Tommi ^a   Saraste, Antti ^a   Koskenvuo, Juha W ^a,b   Pärkkä, Jussi P ^a   Leino, Kari ^a   Laitio, Timo ^a   Stark, Christoffer ^b   Heikkilä, Aira ^c   Saukko, Pekka ^d   Savunen, Timo ^a,b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c ORION CORPORATION   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

Animal model; Apoptosis; Ischemia reperfusion injury; Myocardial protection

Indexed keywords

EID: 84866295518     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00017     Document Type: Article

References (23)

1. Busk, M., Maeng, M., Kristensen, J., Berg, J. S., Mortensen, U. M., Nielsen, T. T., and Nilelsen-Kudsk, J. E. (2006). Effects of levosi-mendan on myocardial infarct size and hemodynamics in a closed-chest porcine ischemia-reperfusion model. Cardiovasc. Drugs Ther. 20, 335-342.
2. Caimmi, P. P., Grossini, E., Molinari, C., Vacca, G., and Teodori, G. (2006). Intracoronary infusion of levosi-mendan totreat postpericardiotomy heart failure. Ann. Thorac. Surg. 82, e33-e34.
3. du Toit, E. F., Genis, A., Opie, L. H., Pollesello, P., and Lochner, A. (2008). A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimen-dan in the isolated guinea pig heart. Br. J. Pharmacol. 154, 41-50.
4. Eriksson, H. I., Jalonen, J. R., Heikki-nen, L. O., Kivikko, M. O., Laine, M., Leino, K.A., Kuitunen, A. H., Kuttila, K. T., Peräkylä, T. K., Sarapohja, T., Suojaranta-Ylinen, R. T., Valtonen, M., and Salmenperä, M. T. (2009). Levosimendan facilitates weaning from cardiopulmonary bypass in patients undergoing coronary artery bypass grafting with impaired left ventricular function. Ann. Thorac. Surg. 87, 448-454.
5. Gottlieb, R. A., Burleson, K. O., Kloner, R. A., Babior, B. M., and Engler, R. L. (1994). Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J. Clin. Invest. 94, 1621-1628.
6. Grossini, E., Caimmi, P. P., Moli-nari, C., Teodori, G., and Vacca, G. (2005). Hemodynamic effect of intracoronary administration of levosimendan in the anesthetized pig. J. Cardiovasc. Pharmacol. 46, 333-342.
7. Grossini, E., Caimmi, P. P., Platini, F., Molnari, C., Uberti, F., Cattaneo, M., Vaenta, G., Mary, D. A., Vagga, G., and Tessitore, L. (2010). Modulation of programmed forms of cell death by intracoronary levosimendan during regional myocardial ischemia in anesthetized pigs. Cardiovasc. Drugs Ther. 24, 5-15.
8. Hasenfuss, G., Pieske, B., Castell, M., Kretschmann, B., Maier, L. S., and Just, H. (1998). Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium. Circulation 98, 2141-2147.
9. Jamali, I. N., Kersten, J. R., Pagel, P. S., Hettrick, D. A., and Warltier, D. C. (1997). Intracoronary levosimen-dan enhances contractile function of stunnedmyocardium. Anesth.Analg. 85, 23-29.
10. Kivikko, M., Antila, S., Eha, J., Lehtonen, L., and Pentikainen, P. J. (2002). Pharmacodynamics and safety of a new calcium sensitizer, levosimen-dan, and its metabolites during an extended infusion in patients with severe heart failure. J. Clin. Pharmacol. 42, 43-51.
11. Kiviniemi, T. O., Toikka, J. O., Koskenvuo, J. W., Saraste, A., Saraste, M., Parkka, J. P., Raitakari, O. T., and Hartiala, J. J. (2007). Vasodi-lation of epicardial coronary artery can be measured with transthoracic echocardiography. Ultrasound Med. Biol. 33, 362-370.
12. Kopustinskiene, D. M., Pollesello, P., and Saris, N. E. (2004). Potassium-specific effects of levosimendan on heart mitochondria. Biochem. Pharmacol. 68, 807-812.
13. Landoni, G., Mizzi, A., Biondi-Zoccai, G., Bruno, G., Bignami, E., Corno, L., Zambon, M., Gerli, C., and Zangrillo, A. (2010). Levosimendan reduces mortality in critically ill patients. A meta-analysis of randomized controlled studies. Minerva Anestesiol. 76, 276-286.
14. Latva-Hirvela, J., Kyto, V., Saraste, A., Vuorinen, T., Levijoki, J., and Saukko, P. (2009). Effects of levosi-mendan in experimental acute cox-sackievirus myocarditis. Eur. J. Clin. Invest. 39, 876-882.
15. Lehtonen, L., and Pöder, P. (2007). The utility of levosimendan in the treatment of heart failure. Ann. Med. 39, 2-17.
16. Louhelainen, M., Vahtola, E., Kaheinen, P., Leskinen, H., Merasto, S., Kytö, V., Finckenberg, P., Colucci, W. S., Levi-joki, J., Pollosello, P., Haikala, H., and Mervaala, E. M. A. (2007). Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats. Br. J. Pharmacol. 150, 851-861.
17. Malmberg, M., Vahasilta, T., Saraste, A., Kytö, V., Kentala, E., Kallajoki, M., and Savunen, T. (2006). Car-diomyocyte apoptosis and duration of aortic clamping in pig model of open heart surgery. Eur. J. Cardiothorac. Surg. 30, 480-484.
18. Maytin, M., and Colucci, W. S. (2005). Cardioprotection: a new paradigm in the management of acute heart failure syndromes. Am. J. Cardiol. 96, 26G-31G.
19. Meyer, K., Schipke, J. D., Klocke, R. C., Gams, E., and Korbmacher, B. (2008). Inotropic, vasodilating and preconditioning actions of levosi-mendan in the heart. Thorac. Car-diovasc. Surg. 56, 379-385.
20. Ozturk, T., Gok, S., and Nese, N. (2010). Levosimendan attenuates reperfu-sion injury in an isolated perfused rat heart model. J. Cardiothorac. Vasc. Anesth. 24, 624-628.
21. Saraste, A., Koskenvuo, J. W., Saraste, M., Parkka, J., Toikka, J., Naum, A., Ukkonen, H., Knuuti, J., Airaksinen, J., and Hartiala, J. (2007). Coronary artery flow velocity profile measured by transthoracic Doppler echocar-diography predicts myocardial viability after acute myocardial infarction. Heart 93, 456-457.
22. Vahasilta, T., Saraste, A., Kyto, V., Malm-berg, M., Kiss, J., Kentala, E., Kalla-joki, M., and Savunen, T. (2005). Cardiomyocyte apoptosis after ante-grade and retrograde cardioplegia. Ann. Thorac. Surg. 80, 2229-2234.
23. Wu, Z. K., Laurikka, J., Saraste, A., Kytö, V., Pehkonen, E. J., Savunen, T., and Tarkka, M. R. (2003). Car-diomyocyte apoptosis and ischemic preconditioning in open heart operations. Ann. Thorac. Surg. 76, 528-534.